diff --git a/packages/react-variant-view/src/component/functionalPrediction/FunctionalPrediction.tsx b/packages/react-variant-view/src/component/functionalPrediction/FunctionalPrediction.tsx
index 63fe6274dca..1c9c31611ef 100644
--- a/packages/react-variant-view/src/component/functionalPrediction/FunctionalPrediction.tsx
+++ b/packages/react-variant-view/src/component/functionalPrediction/FunctionalPrediction.tsx
@@ -28,25 +28,21 @@ interface IFunctionalImpactData {
 @observer
 class FunctionalPrediction extends React.Component<IFunctionalPredictionProps> {
     public getData(
-        genomeNexusData: VariantAnnotation | undefined
+        genomeNexusData: VariantAnnotation | undefined,
+        selectedTranscriptId?: string
     ): IFunctionalImpactData {
         const mutationAssessor = genomeNexusData?.mutation_assessor;
-        const siftScore =
-            genomeNexusData &&
-            genomeNexusData.transcript_consequences &&
-            genomeNexusData.transcript_consequences[0].sift_score;
-        const siftPrediction =
-            genomeNexusData &&
-            genomeNexusData.transcript_consequences &&
-            genomeNexusData.transcript_consequences[0].sift_prediction;
-        const polyPhenScore =
-            genomeNexusData &&
-            genomeNexusData.transcript_consequences &&
-            genomeNexusData.transcript_consequences[0].polyphen_score;
-        const polyPhenPrediction =
-            genomeNexusData &&
-            genomeNexusData.transcript_consequences &&
-            genomeNexusData.transcript_consequences[0].polyphen_prediction;
+        const transcriptConsequence =
+            genomeNexusData && selectedTranscriptId
+                ? genomeNexusData.transcript_consequences.find(
+                      tc => tc.transcript_id === selectedTranscriptId
+                  )
+                : undefined;
+
+        const siftScore = transcriptConsequence?.sift_score;
+        const siftPrediction = transcriptConsequence?.sift_prediction;
+        const polyPhenScore = transcriptConsequence?.polyphen_score;
+        const polyPhenPrediction = transcriptConsequence?.polyphen_prediction;
 
         return {
             mutationAssessor,
diff --git a/src/shared/components/mutationTable/MutationTable.tsx b/src/shared/components/mutationTable/MutationTable.tsx
index ffe8ecfb5bb..f11417d8a46 100644
--- a/src/shared/components/mutationTable/MutationTable.tsx
+++ b/src/shared/components/mutationTable/MutationTable.tsx
@@ -906,7 +906,8 @@ export default class MutationTable<
                     return FunctionalImpactColumnFormatter.renderFunction(
                         d,
                         this.props.genomeNexusCache,
-                        this.props.genomeNexusMutationAssessorCache
+                        this.props.genomeNexusMutationAssessorCache,
+                        this.props.selectedTranscriptId
                     );
                 } else {
                     return <span></span>;
@@ -917,7 +918,8 @@ export default class MutationTable<
                     d,
                     this.props.genomeNexusCache as GenomeNexusCache,
                     this.props
-                        .genomeNexusMutationAssessorCache as GenomeNexusMutationAssessorCache
+                        .genomeNexusMutationAssessorCache as GenomeNexusMutationAssessorCache,
+                    this.props.selectedTranscriptId
                 ),
             headerRender: FunctionalImpactColumnFormatter.headerRender,
             visible: false,
diff --git a/src/shared/components/mutationTable/column/FunctionalImpactColumnFormatter.tsx b/src/shared/components/mutationTable/column/FunctionalImpactColumnFormatter.tsx
index e9f5340a517..be9e674083a 100644
--- a/src/shared/components/mutationTable/column/FunctionalImpactColumnFormatter.tsx
+++ b/src/shared/components/mutationTable/column/FunctionalImpactColumnFormatter.tsx
@@ -25,6 +25,7 @@ import GenomeNexusCache, {
 } from 'shared/cache/GenomeNexusCache';
 import _ from 'lodash';
 import { shouldShowMutationAssessor } from 'shared/lib/genomeNexusAnnotationSourcesUtils';
+import { selected } from 'pages/studyView/table/tables.module.scss';
 
 type FunctionalImpactColumnTooltipProps = {
     active: 'mutationAssessor' | 'sift' | 'polyPhen2';
@@ -457,7 +458,8 @@ export default class FunctionalImpactColumnFormatter {
     public static getData(
         data: Mutation[],
         siftPolyphenCache: GenomeNexusCache,
-        mutationAssessorCache: GenomeNexusMutationAssessorCache
+        mutationAssessorCache: GenomeNexusMutationAssessorCache,
+        selectedTranscriptId?: string
     ): FunctionalImpactData {
         const siftPolyphenCacheData = FunctionalImpactColumnFormatter.getDataFromCache(
             data,
@@ -471,10 +473,13 @@ export default class FunctionalImpactColumnFormatter {
             : null;
 
         const siftData = siftPolyphenCacheData
-            ? this.getSiftData(siftPolyphenCacheData.data)
+            ? this.getSiftData(siftPolyphenCacheData.data, selectedTranscriptId)
             : undefined;
         const polyphenData = siftPolyphenCacheData
-            ? this.getPolyphenData(siftPolyphenCacheData.data)
+            ? this.getPolyphenData(
+                  siftPolyphenCacheData.data,
+                  selectedTranscriptId
+              )
             : undefined;
         const mutationAssessor = mutationAssessorCacheData
             ? this.getMutationAssessorData(mutationAssessorCacheData.data)
@@ -496,17 +501,21 @@ export default class FunctionalImpactColumnFormatter {
         return functionalImpactData;
     }
 
-    public static getSiftData(siftDataCache: VariantAnnotation | null) {
+    public static getSiftData(
+        siftDataCache: VariantAnnotation | null,
+        selectedTranscriptId?: string
+    ) {
         let siftScore: number | undefined = undefined;
         let siftPrediction: string | undefined = undefined;
-
-        if (
-            siftDataCache &&
-            !_.isEmpty(siftDataCache.transcript_consequences)
-        ) {
-            siftScore = siftDataCache.transcript_consequences[0].sift_score;
-            siftPrediction =
-                siftDataCache.transcript_consequences[0].sift_prediction;
+        if (siftDataCache && selectedTranscriptId) {
+            // find transcript consequence that matches the selected transcript
+            const transcriptConsequence = siftDataCache.transcript_consequences.find(
+                tc => tc.transcript_id === selectedTranscriptId
+            );
+            if (transcriptConsequence) {
+                siftScore = transcriptConsequence.sift_score;
+                siftPrediction = transcriptConsequence.sift_prediction;
+            }
         }
 
         return {
@@ -515,19 +524,22 @@ export default class FunctionalImpactColumnFormatter {
         };
     }
 
-    public static getPolyphenData(polyphenDataCache: VariantAnnotation | null) {
+    public static getPolyphenData(
+        polyphenDataCache: VariantAnnotation | null,
+        selectedTranscriptId?: string
+    ) {
         let polyPhenScore: number | undefined = undefined;
         let polyPhenPrediction: string | undefined = undefined;
 
-        if (
-            polyphenDataCache &&
-            !_.isEmpty(polyphenDataCache.transcript_consequences)
-        ) {
-            polyPhenScore =
-                polyphenDataCache.transcript_consequences[0].polyphen_score;
-            polyPhenPrediction =
-                polyphenDataCache.transcript_consequences[0]
-                    .polyphen_prediction;
+        if (polyphenDataCache && selectedTranscriptId) {
+            // find transcript consequence that matches the selected transcript
+            const transcriptConsequence = polyphenDataCache.transcript_consequences.find(
+                tc => tc.transcript_id === selectedTranscriptId
+            );
+            if (transcriptConsequence) {
+                polyPhenScore = transcriptConsequence.polyphen_score;
+                polyPhenPrediction = transcriptConsequence.polyphen_prediction;
+            }
         }
 
         return {
@@ -545,7 +557,8 @@ export default class FunctionalImpactColumnFormatter {
     public static renderFunction(
         data: Mutation[],
         siftPolyphenCache: GenomeNexusCache | undefined,
-        mutationAssessorCache: GenomeNexusMutationAssessorCache | undefined
+        mutationAssessorCache: GenomeNexusMutationAssessorCache | undefined,
+        selectedTranscriptId?: string
     ) {
         const showMutationAssessor = shouldShowMutationAssessor();
 
@@ -564,15 +577,18 @@ export default class FunctionalImpactColumnFormatter {
                 {showMutationAssessor &&
                     FunctionalImpactColumnFormatter.makeFunctionalImpactViz(
                         mutationAssessorCacheData,
-                        FunctionalImpactColumnsName.MUTATION_ASSESSOR
+                        FunctionalImpactColumnsName.MUTATION_ASSESSOR,
+                        selectedTranscriptId
                     )}
                 {FunctionalImpactColumnFormatter.makeFunctionalImpactViz(
                     siftPolyphenCacheData,
-                    FunctionalImpactColumnsName.SIFT
+                    FunctionalImpactColumnsName.SIFT,
+                    selectedTranscriptId
                 )}
                 {FunctionalImpactColumnFormatter.makeFunctionalImpactViz(
                     siftPolyphenCacheData,
-                    FunctionalImpactColumnsName.POLYPHEN2
+                    FunctionalImpactColumnsName.POLYPHEN2,
+                    selectedTranscriptId
                 )}
             </div>
         );
@@ -581,13 +597,15 @@ export default class FunctionalImpactColumnFormatter {
     public static download(
         data: Mutation[],
         siftPolyphenCache: GenomeNexusCache,
-        mutationAssessorCache: GenomeNexusMutationAssessorCache
+        mutationAssessorCache: GenomeNexusMutationAssessorCache,
+        selectedTranscriptId?: string
     ): string {
         if (siftPolyphenCache || mutationAssessorCache) {
             const functionalImpactData = FunctionalImpactColumnFormatter.getData(
                 data,
                 siftPolyphenCache,
-                mutationAssessorCache
+                mutationAssessorCache,
+                selectedTranscriptId
             );
             let downloadData = [];
             if (functionalImpactData) {
@@ -626,7 +644,8 @@ export default class FunctionalImpactColumnFormatter {
 
     private static makeFunctionalImpactViz(
         cacheData: GenomeNexusCacheDataType | null,
-        column: FunctionalImpactColumnsName
+        column: FunctionalImpactColumnsName,
+        selectedTranscriptId?: string
     ) {
         let status: TableCellStatus | null = null;
 
@@ -650,7 +669,8 @@ export default class FunctionalImpactColumnFormatter {
                     );
                 case FunctionalImpactColumnsName.SIFT:
                     functionalImpactData = FunctionalImpactColumnFormatter.getSiftData(
-                        cacheData.data
+                        cacheData.data,
+                        selectedTranscriptId
                     );
                     return (
                         <Sift
@@ -660,7 +680,8 @@ export default class FunctionalImpactColumnFormatter {
                     );
                 case FunctionalImpactColumnsName.POLYPHEN2:
                     functionalImpactData = FunctionalImpactColumnFormatter.getPolyphenData(
-                        cacheData.data
+                        cacheData.data,
+                        selectedTranscriptId
                     );
                     return (
                         <PolyPhen2