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Looking at the code actually making predictions, it appears this argument is not actually ever used-- it was initially used in to allow users to binarize predictions that were generated when Hi-C data is provided (in which case ABC.Score uses Hi-C for contact and powerlaw.Score uses the power law to estimate contact) by either score column.
We modified the code for downstream applications so that when no Hi-C file is provided, the ABC.Score column is identical to powerlaw.Score. Therefore, it is always recommended to filter by ABC.Score.
This one is already defined in the argument of the command line, I think if the hic file does not exist, it will return the "" for hic params.
https://github.com/broadinstitute/ABC-Enhancer-Gene-Prediction/blob/main/workflow/rules/predictions.smk#L10C3-L10C41
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