diff --git a/crates/revm/Cargo.toml b/crates/revm/Cargo.toml
index 3cfe860376..e14a223ed9 100644
--- a/crates/revm/Cargo.toml
+++ b/crates/revm/Cargo.toml
@@ -114,6 +114,11 @@ name = "generate_block_traces"
 path = "../../examples/generate_block_traces.rs"
 required-features = ["std", "serde-json", "ethersdb"]
 
+[[example]]
+name = "db_by_ref"
+path = "../../examples/db_by_ref.rs"
+required-features = ["std", "serde-json"]
+
 [[bench]]
 name = "bench"
 path = "benches/bench.rs"
diff --git a/crates/revm/src/builder.rs b/crates/revm/src/builder.rs
index 20a8fd37a0..cc177e1b96 100644
--- a/crates/revm/src/builder.rs
+++ b/crates/revm/src/builder.rs
@@ -284,8 +284,8 @@ impl<'a, BuilderStage, EXT, DB: Database> EvmBuilder<'a, BuilderStage, EXT, DB>
     /// When called, EvmBuilder will transition from SetGenericStage to HandlerStage.
     pub fn append_handler_register(
         mut self,
-        handle_register: register::HandleRegister<'a, EXT, DB>,
-    ) -> EvmBuilder<'_, HandlerStage, EXT, DB> {
+        handle_register: register::HandleRegister<EXT, DB>,
+    ) -> EvmBuilder<'a, HandlerStage, EXT, DB> {
         self.handler
             .append_handler_register(register::HandleRegisters::Plain(handle_register));
         EvmBuilder {
@@ -302,8 +302,8 @@ impl<'a, BuilderStage, EXT, DB: Database> EvmBuilder<'a, BuilderStage, EXT, DB>
     /// When called, EvmBuilder will transition from SetGenericStage to HandlerStage.
     pub fn append_handler_register_box(
         mut self,
-        handle_register: register::HandleRegisterBox<'a, EXT, DB>,
-    ) -> EvmBuilder<'_, HandlerStage, EXT, DB> {
+        handle_register: register::HandleRegisterBox<EXT, DB>,
+    ) -> EvmBuilder<'a, HandlerStage, EXT, DB> {
         self.handler
             .append_handler_register(register::HandleRegisters::Box(handle_register));
         EvmBuilder {
diff --git a/crates/revm/src/handler.rs b/crates/revm/src/handler.rs
index bba5192543..35ad55af99 100644
--- a/crates/revm/src/handler.rs
+++ b/crates/revm/src/handler.rs
@@ -29,7 +29,7 @@ pub struct Handler<'a, H: Host + 'a, EXT, DB: Database> {
     /// Instruction table type.
     pub instruction_table: Option<InstructionTables<'a, H>>,
     /// Registers that will be called on initialization.
-    pub registers: Vec<HandleRegisters<'a, EXT, DB>>,
+    pub registers: Vec<HandleRegisters<EXT, DB>>,
     /// Validity handles.
     pub validation: ValidationHandler<'a, EXT, DB>,
     /// Pre execution handle
@@ -138,25 +138,25 @@ impl<'a, EXT, DB: Database> EvmHandler<'a, EXT, DB> {
     }
 
     /// Append handle register.
-    pub fn append_handler_register(&mut self, register: HandleRegisters<'a, EXT, DB>) {
+    pub fn append_handler_register(&mut self, register: HandleRegisters<EXT, DB>) {
         register.register(self);
         self.registers.push(register);
     }
 
     /// Append plain handle register.
-    pub fn append_handler_register_plain(&mut self, register: HandleRegister<'a, EXT, DB>) {
+    pub fn append_handler_register_plain(&mut self, register: HandleRegister<EXT, DB>) {
         register(self);
         self.registers.push(HandleRegisters::Plain(register));
     }
 
     /// Append boxed handle register.
-    pub fn append_handler_register_box(&mut self, register: HandleRegisterBox<'a, EXT, DB>) {
+    pub fn append_handler_register_box(&mut self, register: HandleRegisterBox<EXT, DB>) {
         register(self);
         self.registers.push(HandleRegisters::Box(register));
     }
 
     /// Pop last handle register and reapply all registers that are left.
-    pub fn pop_handle_register(&mut self) -> Option<HandleRegisters<'a, EXT, DB>> {
+    pub fn pop_handle_register(&mut self) -> Option<HandleRegisters<EXT, DB>> {
         let out = self.registers.pop();
         if out.is_some() {
             let registers = core::mem::take(&mut self.registers);
@@ -211,7 +211,7 @@ mod test {
 
     #[test]
     fn test_handler_register_pop() {
-        let register = |inner: &Rc<RefCell<i32>>| -> HandleRegisterBox<'_, (), EmptyDB> {
+        let register = |inner: &Rc<RefCell<i32>>| -> HandleRegisterBox<(), EmptyDB> {
             let inner = inner.clone();
             Box::new(move |h| {
                 *inner.borrow_mut() += 1;
diff --git a/crates/revm/src/handler/register.rs b/crates/revm/src/handler/register.rs
index 835b80e2c8..ba7980f06e 100644
--- a/crates/revm/src/handler/register.rs
+++ b/crates/revm/src/handler/register.rs
@@ -8,21 +8,21 @@ pub type EvmHandler<'a, EXT, DB> = Handler<'a, Evm<'a, EXT, DB>, EXT, DB>;
 pub type EvmInstructionTables<'a, EXT, DB> = InstructionTables<'a, Evm<'a, EXT, DB>>;
 
 // Handle register
-pub type HandleRegister<'a, EXT, DB> = fn(&mut EvmHandler<'a, EXT, DB>);
+pub type HandleRegister<EXT, DB> = for<'a> fn(&mut EvmHandler<'a, EXT, DB>);
 
 // Boxed handle register
-pub type HandleRegisterBox<'a, EXT, DB> = Box<dyn Fn(&mut EvmHandler<'a, EXT, DB>)>;
+pub type HandleRegisterBox<EXT, DB> = Box<dyn for<'a> Fn(&mut EvmHandler<'a, EXT, DB>)>;
 
-pub enum HandleRegisters<'a, EXT, DB: Database> {
+pub enum HandleRegisters<EXT, DB: Database> {
     /// Plain function register
-    Plain(HandleRegister<'a, EXT, DB>),
+    Plain(HandleRegister<EXT, DB>),
     /// Boxed function register.
-    Box(HandleRegisterBox<'a, EXT, DB>),
+    Box(HandleRegisterBox<EXT, DB>),
 }
 
-impl<'a, EXT, DB: Database> HandleRegisters<'a, EXT, DB> {
+impl<EXT, DB: Database> HandleRegisters<EXT, DB> {
     /// Call register function to modify EvmHandler.
-    pub fn register(&self, handler: &mut EvmHandler<'a, EXT, DB>) {
+    pub fn register(&self, handler: &mut EvmHandler<'_, EXT, DB>) {
         match self {
             HandleRegisters::Plain(f) => f(handler),
             HandleRegisters::Box(f) => f(handler),
diff --git a/examples/db_by_ref.rs b/examples/db_by_ref.rs
new file mode 100644
index 0000000000..01f51faec3
--- /dev/null
+++ b/examples/db_by_ref.rs
@@ -0,0 +1,81 @@
+use revm::{
+    db::{CacheDB, EmptyDB, WrapDatabaseRef},
+    handler::register::HandleRegister,
+    inspector_handle_register,
+    inspectors::{NoOpInspector, TracerEip3155},
+    primitives::ResultAndState,
+    DatabaseCommit, DatabaseRef, Evm,
+};
+use std::error::Error;
+
+trait DatabaseRefDebugError: DatabaseRef<Error = Self::DBError> {
+    type DBError: std::fmt::Debug + Error + Send + Sync + 'static;
+}
+
+impl<DBError, DB> DatabaseRefDebugError for DB
+where
+    DB: DatabaseRef<Error = DBError>,
+    DBError: std::fmt::Debug + Error + Send + Sync + 'static,
+{
+    type DBError = DBError;
+}
+
+fn run_transaction<EXT, DB: DatabaseRefDebugError>(
+    db: DB,
+    ext: EXT,
+    register_handles_fn: HandleRegister<EXT, WrapDatabaseRef<DB>>,
+) -> anyhow::Result<(ResultAndState, DB)> {
+    let mut evm = Evm::builder()
+        .with_ref_db(db)
+        .with_external_context(ext)
+        .append_handler_register(register_handles_fn)
+        .build();
+
+    let result = evm.transact()?;
+    Ok((result, evm.into_context().evm.db.0))
+}
+
+fn run_transaction_and_commit_with_ext<EXT, DB: DatabaseRefDebugError + DatabaseCommit>(
+    db: DB,
+    ext: EXT,
+    register_handles_fn: HandleRegister<EXT, WrapDatabaseRef<DB>>,
+) -> anyhow::Result<()> {
+    // To circumvent borrow checker issues, we need to move the database into the
+    // transaction and return it after the transaction is done.
+    let (ResultAndState { state: changes, .. }, mut db) =
+        { run_transaction(db, ext, register_handles_fn)? };
+
+    db.commit(changes);
+
+    Ok(())
+}
+
+fn run_transaction_and_commit(db: &mut CacheDB<EmptyDB>) -> anyhow::Result<()> {
+    let ResultAndState { state: changes, .. } = {
+        let rdb = &*db;
+
+        let mut evm = Evm::builder()
+            .with_ref_db(rdb)
+            .with_external_context(NoOpInspector)
+            .append_handler_register(inspector_handle_register)
+            .build();
+
+        evm.transact()?
+    };
+
+    // No compiler error because there is no lifetime parameter for the `HandleRegister` function
+    db.commit(changes);
+
+    Ok(())
+}
+
+fn main() -> anyhow::Result<()> {
+    let mut cache_db = CacheDB::new(EmptyDB::default());
+
+    let mut tracer = TracerEip3155::new(Box::new(std::io::stdout()), true, true);
+
+    run_transaction_and_commit_with_ext(&mut cache_db, &mut tracer, inspector_handle_register)?;
+    run_transaction_and_commit(&mut cache_db)?;
+
+    Ok(())
+}