diff --git a/aws_lambda_powertools/event_handler/api_gateway.py b/aws_lambda_powertools/event_handler/api_gateway.py
index 8de90407675..1e6fe2a50bb 100644
--- a/aws_lambda_powertools/event_handler/api_gateway.py
+++ b/aws_lambda_powertools/event_handler/api_gateway.py
@@ -724,10 +724,11 @@ def _remove_prefix(self, path: str) -> str:
             if isinstance(prefix, Pattern):
                 path = re.sub(prefix, "", path)
 
-        # When using regexes, we might get into a point where everything is removed
-        # from the string, so we check if it's empty and change it accordingly.
-        if not path:
-            path = "/"
+                # When using regexes, we might get into a point where everything is removed
+                # from the string, so we check if it's empty and return /, since there's nothing
+                # else to strip anymore.
+                if not path:
+                    return "/"
 
         return path
 
diff --git a/tests/functional/event_handler/test_api_gateway.py b/tests/functional/event_handler/test_api_gateway.py
index f40bb2439ee..2afd1241bed 100644
--- a/tests/functional/event_handler/test_api_gateway.py
+++ b/tests/functional/event_handler/test_api_gateway.py
@@ -1098,6 +1098,18 @@ def foo():
     assert response["statusCode"] == 200
 
 
+def test_empty_path_when_using_regexes():
+    app = ApiGatewayResolver(strip_prefixes=[re.compile(r"/(dev|stg)")])
+
+    @app.get("/")
+    def foo():
+        ...
+
+    response = app({"httpMethod": "GET", "path": "/dev"}, None)
+
+    assert response["statusCode"] == 200
+
+
 @pytest.mark.parametrize(
     "prefix",
     [