diff --git a/crates/ruff_linter/resources/test/fixtures/pycodestyle/E721.py b/crates/ruff_linter/resources/test/fixtures/pycodestyle/E721.py
index 872fa7042aded1..9ce183b6adad82 100644
--- a/crates/ruff_linter/resources/test/fixtures/pycodestyle/E721.py
+++ b/crates/ruff_linter/resources/test/fixtures/pycodestyle/E721.py
@@ -126,3 +126,15 @@ def type():
         # Okay
         if type(value) is str:
             ...
+
+
+import numpy as np
+
+#: Okay
+x.dtype == float
+
+#: Okay
+np.dtype(int) == float
+
+#: E721
+dtype == float
diff --git a/crates/ruff_linter/src/rules/pycodestyle/rules/type_comparison.rs b/crates/ruff_linter/src/rules/pycodestyle/rules/type_comparison.rs
index 598b9a9c119722..57de972c231771 100644
--- a/crates/ruff_linter/src/rules/pycodestyle/rules/type_comparison.rs
+++ b/crates/ruff_linter/src/rules/pycodestyle/rules/type_comparison.rs
@@ -162,7 +162,14 @@ pub(crate) fn preview_type_comparison(checker: &mut Checker, compare: &ast::Expr
         .filter(|(_, op)| matches!(op, CmpOp::Eq | CmpOp::NotEq))
         .map(|((left, right), _)| (left, right))
     {
+        // If either expression is a type...
         if is_type(left, checker.semantic()) || is_type(right, checker.semantic()) {
+            // And neither is a `dtype`...
+            if is_dtype(left, checker.semantic()) || is_dtype(right, checker.semantic()) {
+                continue;
+            }
+
+            // Disallow the comparison.
             checker.diagnostics.push(Diagnostic::new(
                 TypeComparison {
                     preview: PreviewMode::Enabled,
@@ -295,3 +302,23 @@ fn is_type(expr: &Expr, semantic: &SemanticModel) -> bool {
         _ => false,
     }
 }
+
+/// Returns `true` if the [`Expr`] appears to be a reference to a NumPy dtype, since:
+/// > `dtype` are a bit of a strange beast, but definitely best thought of as instances, not
+/// > classes, and they are meant to be comparable not just to their own class, but also to the
+/// corresponding scalar types (e.g., `x.dtype == np.float32`) and strings (e.g.,
+/// `x.dtype == ['i1,i4']`; basically, __eq__ always tries to do `dtype(other)`).
+fn is_dtype(expr: &Expr, semantic: &SemanticModel) -> bool {
+    match expr {
+        // Ex) `np.dtype(obj)`
+        Expr::Call(ast::ExprCall { func, .. }) => semantic
+            .resolve_call_path(func)
+            .is_some_and(|call_path| matches!(call_path.as_slice(), ["numpy", "dtype"])),
+        // Ex) `obj.dtype`
+        Expr::Attribute(ast::ExprAttribute { attr, .. }) => {
+            // Ex) `obj.dtype`
+            attr.as_str() == "dtype"
+        }
+        _ => false,
+    }
+}
diff --git a/crates/ruff_linter/src/rules/pycodestyle/snapshots/ruff_linter__rules__pycodestyle__tests__preview__E721_E721.py.snap b/crates/ruff_linter/src/rules/pycodestyle/snapshots/ruff_linter__rules__pycodestyle__tests__preview__E721_E721.py.snap
index 8971d3f3ccf065..fc1d13521fdae6 100644
--- a/crates/ruff_linter/src/rules/pycodestyle/snapshots/ruff_linter__rules__pycodestyle__tests__preview__E721_E721.py.snap
+++ b/crates/ruff_linter/src/rules/pycodestyle/snapshots/ruff_linter__rules__pycodestyle__tests__preview__E721_E721.py.snap
@@ -129,4 +129,11 @@ E721.py:59:4: E721 Use `is` and `is not` for type comparisons, or `isinstance()`
 61 | #: Okay
    |
 
+E721.py:140:1: E721 Use `is` and `is not` for type comparisons, or `isinstance()` for isinstance checks
+    |
+139 | #: E721
+140 | dtype == float
+    | ^^^^^^^^^^^^^^ E721
+    |
+