diff --git a/crates/ruff_linter/resources/test/fixtures/flake8_slots/SLOT000.py b/crates/ruff_linter/resources/test/fixtures/flake8_slots/SLOT000.py
index 425fc3b9013ef..c3bb79b633804 100644
--- a/crates/ruff_linter/resources/test/fixtures/flake8_slots/SLOT000.py
+++ b/crates/ruff_linter/resources/test/fixtures/flake8_slots/SLOT000.py
@@ -11,3 +11,11 @@ class Good(str):  # Ok
 
 class Fine(str, Enum):  # Ok
     __slots__ = ["foo"]
+
+
+class SubEnum(Enum):
+    pass
+
+
+class Ok(str, SubEnum):  # Ok
+    pass
diff --git a/crates/ruff_linter/src/rules/flake8_slots/rules/no_slots_in_str_subclass.rs b/crates/ruff_linter/src/rules/flake8_slots/rules/no_slots_in_str_subclass.rs
index 4c9006ff03f79..a0ffe23e3b01f 100644
--- a/crates/ruff_linter/src/rules/flake8_slots/rules/no_slots_in_str_subclass.rs
+++ b/crates/ruff_linter/src/rules/flake8_slots/rules/no_slots_in_str_subclass.rs
@@ -1,9 +1,8 @@
-use ruff_python_ast::{Arguments, Expr, Stmt, StmtClassDef};
-
 use ruff_diagnostics::{Diagnostic, Violation};
 use ruff_macros::{derive_message_formats, violation};
 use ruff_python_ast::identifier::Identifier;
-use ruff_python_semantic::SemanticModel;
+use ruff_python_ast::{Arguments, Expr, Stmt, StmtClassDef};
+use ruff_python_semantic::{analyze, SemanticModel};
 
 use crate::checkers::ast::Checker;
 use crate::rules::flake8_slots::rules::helpers::has_slots;
@@ -55,33 +54,40 @@ pub(crate) fn no_slots_in_str_subclass(checker: &mut Checker, stmt: &Stmt, class
         return;
     };
 
-    if is_str_subclass(bases, checker.semantic()) {
-        if !has_slots(&class.body) {
-            checker
-                .diagnostics
-                .push(Diagnostic::new(NoSlotsInStrSubclass, stmt.identifier()));
-        }
+    if !is_str_subclass(bases, checker.semantic()) {
+        return;
+    }
+
+    // Ignore subclasses of `enum.Enum` et al.
+    if is_enum_subclass(class, checker.semantic()) {
+        return;
+    }
+
+    if has_slots(&class.body) {
+        return;
     }
+
+    checker
+        .diagnostics
+        .push(Diagnostic::new(NoSlotsInStrSubclass, stmt.identifier()));
 }
 
-/// Return `true` if the class is a subclass of `str`, but _not_ a subclass of `enum.Enum`,
-/// `enum.IntEnum`, etc.
+/// Return `true` if the class is a subclass of `str`.
 fn is_str_subclass(bases: &[Expr], semantic: &SemanticModel) -> bool {
-    let mut is_str_subclass = false;
-    for base in bases {
-        if let Some(qualified_name) = semantic.resolve_qualified_name(base) {
-            match qualified_name.segments() {
-                ["" | "builtins", "str"] => {
-                    is_str_subclass = true;
-                }
-                ["enum", "Enum" | "IntEnum" | "StrEnum" | "Flag" | "IntFlag" | "ReprEnum" | "EnumCheck"] =>
-                {
-                    // Ignore enum classes.
-                    return false;
-                }
-                _ => {}
-            }
-        }
-    }
-    is_str_subclass
+    bases
+        .iter()
+        .any(|base| semantic.match_builtin_expr(base, "str"))
+}
+
+/// Returns `true` if the class is an enum subclass, at any depth.
+fn is_enum_subclass(class_def: &StmtClassDef, semantic: &SemanticModel) -> bool {
+    analyze::class::any_qualified_name(class_def, semantic, &|qualified_name| {
+        matches!(
+            qualified_name.segments(),
+            [
+                "enum",
+                "Enum" | "IntEnum" | "StrEnum" | "Flag" | "IntFlag" | "ReprEnum" | "EnumCheck"
+            ]
+        )
+    })
 }