diff --git a/changelogs/fragments/188-httprequestmethodconfig-keyerror.yaml b/changelogs/fragments/188-httprequestmethodconfig-keyerror.yaml
new file mode 100644
index 00000000000..5b7ac63aec4
--- /dev/null
+++ b/changelogs/fragments/188-httprequestmethodconfig-keyerror.yaml
@@ -0,0 +1,5 @@
+---
+bugfixes:
+  - module_utils/elbv2 - add logic to compare_rules to suit Values list nested within dicts unique to each field type. 
+    Fixes issue (https://github.com/ansible-collections/amazon.aws/issues/187)
+  - module_utils/elbv2 - Requires 1.16.57 as minimum boto3 version.
diff --git a/plugins/module_utils/elbv2.py b/plugins/module_utils/elbv2.py
index 8ae12e01172..2124a61a68c 100644
--- a/plugins/module_utils/elbv2.py
+++ b/plugins/module_utils/elbv2.py
@@ -51,6 +51,9 @@ def __init__(self, connection, module):
         else:
             self.elb_attributes = None
 
+        if not self.module.boto3_at_least('1.16.57'):
+            self.module.fail_json(msg="elbv2 requires boto3 >= 1.16.57")
+
     def wait_for_status(self, elb_arn):
         """
         Wait for load balancer to reach 'active' status
@@ -719,11 +722,46 @@ def _compare_condition(self, current_conditions, condition):
         condition_found = False
 
         for current_condition in current_conditions:
-            if current_condition.get('SourceIpConfig'):
+            # host-header: current_condition includes both HostHeaderConfig AND Values while
+            # condition can be defined with either HostHeaderConfig OR Values. Only use
+            # HostHeaderConfig['Values'] comparison if both conditions includes HostHeaderConfig.
+            if current_condition.get('HostHeaderConfig') and condition.get('HostHeaderConfig'):
+                if (current_condition['Field'] == condition['Field'] and
+                        sorted(current_condition['HostHeaderConfig']['Values']) == sorted(condition['HostHeaderConfig']['Values'])):
+                    condition_found = True
+                    break
+            elif current_condition.get('HttpHeaderConfig'):
+                if (current_condition['Field'] == condition['Field'] and
+                        sorted(current_condition['HttpHeaderConfig']['Values']) == sorted(condition['HttpHeaderConfig']['Values']) and
+                        current_condition['HttpHeaderConfig']['HttpHeaderName'] == condition['HttpHeaderConfig']['HttpHeaderName']):
+                    condition_found = True
+                    break
+            elif current_condition.get('HttpRequestMethodConfig'):
+                if (current_condition['Field'] == condition['Field'] and
+                        sorted(current_condition['HttpRequestMethodConfig']['Values']) == sorted(condition['HttpRequestMethodConfig']['Values'])):
+                    condition_found = True
+                    break
+            # path-pattern: current_condition includes both PathPatternConfig AND Values while
+            # condition can be defined with either PathPatternConfig OR Values. Only use
+            # PathPatternConfig['Values'] comparison if both conditions includes PathPatternConfig.
+            elif current_condition.get('PathPatternConfig') and condition.get('PathPatternConfig'):
+                if (current_condition['Field'] == condition['Field'] and
+                        sorted(current_condition['PathPatternConfig']['Values']) == sorted(condition['PathPatternConfig']['Values'])):
+                    condition_found = True
+                    break
+            elif current_condition.get('QueryStringConfig'):
+                # QueryString Values is not sorted as it is the only list of dicts (not strings).
+                if (current_condition['Field'] == condition['Field'] and
+                        current_condition['QueryStringConfig']['Values'] == condition['QueryStringConfig']['Values']):
+                    condition_found = True
+                    break
+            elif current_condition.get('SourceIpConfig'):
                 if (current_condition['Field'] == condition['Field'] and
-                        current_condition['SourceIpConfig']['Values'][0] == condition['SourceIpConfig']['Values'][0]):
+                        sorted(current_condition['SourceIpConfig']['Values']) == sorted(condition['SourceIpConfig']['Values'])):
                     condition_found = True
                     break
+            # Not all fields are required to have Values list nested within a *Config dict
+            # e.g. fields host-header/path-pattern can directly list Values
             elif current_condition['Field'] == condition['Field'] and sorted(current_condition['Values']) == sorted(condition['Values']):
                 condition_found = True
                 break