diff --git a/packages/angular_devkit/build_angular/src/babel/plugins/adjust-static-class-members.ts b/packages/angular_devkit/build_angular/src/babel/plugins/adjust-static-class-members.ts
index 4c9adc23c7bd..ff0dee19e75b 100644
--- a/packages/angular_devkit/build_angular/src/babel/plugins/adjust-static-class-members.ts
+++ b/packages/angular_devkit/build_angular/src/babel/plugins/adjust-static-class-members.ts
@@ -205,6 +205,7 @@ const exportDefaultAnalysis = new WeakMap<types.Class, ReturnType<typeof analyze
  *
  * @returns A babel plugin object instance.
  */
+// eslint-disable-next-line max-lines-per-function
 export default function (): PluginObj {
   return {
     visitor: {
@@ -278,6 +279,47 @@ export default function (): PluginObj {
                 shouldWrap = false;
                 break;
               }
+              // eslint-disable-next-line @typescript-eslint/no-explicit-any
+            } else if ((element as any).isStaticBlock()) {
+              // Only need to analyze static blocks
+              const body = element.get('body');
+
+              if (Array.isArray(body) && body.length > 1) {
+                // Not safe to wrap
+                shouldWrap = false;
+                break;
+              }
+
+              const expression = body.find((n: NodePath<types.Node>) =>
+                n.isExpressionStatement(),
+              ) as NodePath<types.ExpressionStatement> | undefined;
+
+              const assignmentExpression = expression?.get('expression');
+              if (assignmentExpression?.isAssignmentExpression()) {
+                const left = assignmentExpression.get('left');
+                if (!left.isMemberExpression()) {
+                  continue;
+                }
+
+                if (!left.get('object').isThisExpression()) {
+                  // Not safe to wrap
+                  shouldWrap = false;
+                  break;
+                }
+
+                const element = left.get('property');
+                const right = assignmentExpression.get('right');
+                if (
+                  element.isIdentifier() &&
+                  (!right.isExpression() || canWrapProperty(element.node.name, right))
+                ) {
+                  shouldWrap = true;
+                } else {
+                  // Not safe to wrap
+                  shouldWrap = false;
+                  break;
+                }
+              }
             }
           }
           if (!shouldWrap) {
diff --git a/packages/angular_devkit/build_angular/src/babel/plugins/adjust-static-class-members_spec.ts b/packages/angular_devkit/build_angular/src/babel/plugins/adjust-static-class-members_spec.ts
index 4b078a0f02b1..dbb9036e40af 100644
--- a/packages/angular_devkit/build_angular/src/babel/plugins/adjust-static-class-members_spec.ts
+++ b/packages/angular_devkit/build_angular/src/babel/plugins/adjust-static-class-members_spec.ts
@@ -669,6 +669,42 @@ describe('adjust-static-class-members Babel plugin', () => {
     });
   });
 
+  it('wraps class with Angular ɵfac static block (ES2022 + useDefineForClassFields: false)', () => {
+    testCase({
+      input: `
+        class CommonModule {
+          static { this.ɵfac = function CommonModule_Factory(t) { return new (t || CommonModule)(); }; }
+          static { this.ɵmod = ɵngcc0.ɵɵdefineNgModule({ type: CommonModule }); }
+        }
+      `,
+      expected: `
+        let CommonModule = /*#__PURE__*/ (() => {
+          class CommonModule {
+            static {
+              this.ɵfac = function CommonModule_Factory(t) {
+                return new (t || CommonModule)();
+              };
+            }
+            static {
+              this.ɵmod = ɵngcc0.ɵɵdefineNgModule({
+                type: CommonModule,
+              });
+            }
+          }
+          return CommonModule;
+        })();
+      `,
+    });
+  });
+
+  it('does not wrap class with side effect full static block (ES2022 + useDefineForClassFields: false)', () => {
+    testCaseNoChange(`
+        class CommonModule {
+          static { globalThis.bar = 1 }
+        }
+      `);
+  });
+
   it('wraps class with Angular ɵmod static field', () => {
     testCase({
       input: `