diff --git a/spyder/plugins/pylint/plugin.py b/spyder/plugins/pylint/plugin.py
index 752f623d285..a1f2563cf26 100644
--- a/spyder/plugins/pylint/plugin.py
+++ b/spyder/plugins/pylint/plugin.py
@@ -16,7 +16,8 @@
 
 # Local imports
 from spyder.api.plugins import Plugins, SpyderDockablePlugin
-from spyder.api.plugin_registration.decorators import on_plugin_available
+from spyder.api.plugin_registration.decorators import (
+    on_plugin_available, on_plugin_teardown)
 from spyder.api.translations import get_translation
 from spyder.utils.programs import is_module_installed
 from spyder.plugins.mainmenu.api import ApplicationMenus
@@ -116,10 +117,13 @@ def on_projects_available(self):
 
         # Connect to projects
         projects = self.get_plugin(Plugins.Projects)
-        projects.sig_project_loaded.connect(
+        self._set_project_dir = (
             lambda value: widget.set_conf("project_dir", value))
-        projects.sig_project_closed.connect(
-            lambda value: widget.set_conf("project_dir", None))
+        self._unset_project_dir = (
+            lambda value: widget.set_conf("project_dir", value))
+
+        projects.sig_project_loaded.connect(self._set_project_dir)
+        projects.sig_project_closed.connect(self._unset_project_dir)
 
     @on_plugin_available(plugin=Plugins.MainMenu)
     def on_main_menu_available(self):
@@ -129,6 +133,46 @@ def on_main_menu_available(self):
         mainmenu.add_item_to_application_menu(
             pylint_act, menu_id=ApplicationMenus.Source)
 
+    @on_plugin_teardown(plugin=Plugins.Editor)
+    def on_editor_teardown(self):
+        widget = self.get_widget()
+        editor = self.get_plugin(Plugins.Editor)
+
+        # Connect to Editor
+        widget.sig_edit_goto_requested.disconnect(editor.load)
+        editor.sig_editor_focus_changed.disconnect(self._set_filename)
+
+        pylint_act = self.get_action(PylintActions.AnalyzeCurrentFile)
+
+        # TODO: use new API when editor has migrated
+        editor.pythonfile_dependent_actions.remove(pylint_act)
+
+    @on_plugin_teardown(plugin=Plugins.Preferences)
+    def on_preferences_teardown(self):
+        preferences = self.get_plugin(Plugins.Preferences)
+        preferences.deregister_plugin_preferences(self)
+
+    @on_plugin_teardown(plugin=Plugins.Projects)
+    def on_projects_teardown(self):
+        widget = self.get_widget()
+
+        # Connect to projects
+        projects = self.get_plugin(Plugins.Projects)
+        projects.sig_project_loaded.disconnect(self._set_project_dir)
+        projects.sig_project_closed.disconnect(self._unset_project_dir)
+
+        self._set_project_dir = None
+        self._unset_project_dir = None
+
+    @on_plugin_teardown(plugin=Plugins.MainMenu)
+    def on_main_menu_teardown(self):
+        mainmenu = self.get_plugin(Plugins.MainMenu)
+
+        pylint_act = self.get_action(PylintActions.AnalyzeCurrentFile)
+        source_menu = mainmenu.get_application_menu(
+            ApplicationMenus.Source)
+        mainmenu.remove_item_from_application_menu(pylint_act, menu=source_menu)
+
     # --- Private API
     # ------------------------------------------------------------------------
     @Slot()
diff --git a/spyder/plugins/run/plugin.py b/spyder/plugins/run/plugin.py
index 34b1a6c4a61..3d0c0e42d30 100644
--- a/spyder/plugins/run/plugin.py
+++ b/spyder/plugins/run/plugin.py
@@ -12,7 +12,8 @@
 
 # Local imports
 from spyder.api.plugins import Plugins, SpyderPluginV2
-from spyder.api.plugin_registration.decorators import on_plugin_available
+from spyder.api.plugin_registration.decorators import (
+    on_plugin_available, on_plugin_teardown)
 from spyder.api.translations import get_translation
 from spyder.plugins.run.confpage import RunConfigPage
 
@@ -54,5 +55,10 @@ def on_preferences_available(self):
         preferences = self.get_plugin(Plugins.Preferences)
         preferences.register_plugin_preferences(self)
 
+    @on_plugin_teardown(plugin=Plugins.Preferences)
+    def on_preferences_teardown(self):
+        preferences = self.get_plugin(Plugins.Preferences)
+        preferences.deregister_plugin_preferences(self)
+
     # --- Public API
     # ------------------------------------------------------------------------
diff --git a/spyder/plugins/shortcuts/plugin.py b/spyder/plugins/shortcuts/plugin.py
index 72291f19873..f7e37a90833 100644
--- a/spyder/plugins/shortcuts/plugin.py
+++ b/spyder/plugins/shortcuts/plugin.py
@@ -21,7 +21,8 @@
 
 # Local imports
 from spyder.api.plugins import Plugins, SpyderPluginV2
-from spyder.api.plugin_registration.decorators import on_plugin_available
+from spyder.api.plugin_registration.decorators import (
+    on_plugin_available, on_plugin_teardown)
 from spyder.api.translations import get_translation
 from spyder.plugins.mainmenu.api import ApplicationMenus, HelpMenuSections
 from spyder.plugins.shortcuts.confpage import ShortcutsConfigPage
@@ -97,6 +98,24 @@ def on_main_menu_available(self):
             section=HelpMenuSections.Documentation,
         )
 
+    @on_plugin_teardown(plugin=Plugins.Preferences)
+    def on_preferences_teardown(self):
+        preferences = self.get_plugin(Plugins.Preferences)
+        preferences.deregister_plugin_preferences(self)
+
+    @on_plugin_teardown(plugin=Plugins.MainMenu)
+    def on_main_menu_teardown(self):
+        mainmenu = self.get_plugin(Plugins.MainMenu)
+        shortcuts_action = self.get_action(
+            ShortcutActions.ShortcutSummaryAction)
+
+        # Add to Help menu.
+        help_menu = mainmenu.get_application_menu(ApplicationMenus.Help)
+        mainmenu.remove_item_from_application_menu(
+            shortcuts_action,
+            menu=help_menu
+        )
+
     def on_mainwindow_visible(self):
         self.apply_shortcuts()