diff --git a/packages/react-dom/src/__tests__/ReactDOMServerIntegrationElements-test.js b/packages/react-dom/src/__tests__/ReactDOMServerIntegrationElements-test.js
index c41170aa54e91..a856bd42edc1d 100644
--- a/packages/react-dom/src/__tests__/ReactDOMServerIntegrationElements-test.js
+++ b/packages/react-dom/src/__tests__/ReactDOMServerIntegrationElements-test.js
@@ -87,17 +87,8 @@ describe('ReactDOMServerIntegration', () => {
             {''}
           </div>,
         );
-        if (render === serverRender || render === streamRender) {
-          // For plain server markup result we should have no text nodes if
-          // they're all empty.
-          expect(e.childNodes.length).toBe(0);
-          expect(e.textContent).toBe('');
-        } else {
-          expect(e.childNodes.length).toBe(3);
-          expectTextNode(e.childNodes[0], '');
-          expectTextNode(e.childNodes[1], '');
-          expectTextNode(e.childNodes[2], '');
-        }
+        expect(e.childNodes.length).toBe(0);
+        expect(e.textContent).toBe('');
       });
 
       itRenders('a div with multiple whitespace children', async render => {
@@ -162,27 +153,14 @@ describe('ReactDOMServerIntegration', () => {
 
       itRenders('a leading blank child with a text sibling', async render => {
         const e = await render(<div>{''}foo</div>);
-        if (render === serverRender || render === streamRender) {
-          expect(e.childNodes.length).toBe(1);
-          expectTextNode(e.childNodes[0], 'foo');
-        } else {
-          expect(e.childNodes.length).toBe(2);
-          expectTextNode(e.childNodes[0], '');
-          expectTextNode(e.childNodes[1], 'foo');
-        }
+        expect(e.childNodes.length).toBe(1);
+        expectTextNode(e.childNodes[0], 'foo');
       });
 
       itRenders('a trailing blank child with a text sibling', async render => {
         const e = await render(<div>foo{''}</div>);
-        // with Fiber, there are just two text nodes.
-        if (render === serverRender || render === streamRender) {
-          expect(e.childNodes.length).toBe(1);
-          expectTextNode(e.childNodes[0], 'foo');
-        } else {
-          expect(e.childNodes.length).toBe(2);
-          expectTextNode(e.childNodes[0], 'foo');
-          expectTextNode(e.childNodes[1], '');
-        }
+        expect(e.childNodes.length).toBe(1);
+        expectTextNode(e.childNodes[0], 'foo');
       });
 
       itRenders('an element with two text children', async render => {
diff --git a/packages/react-dom/src/__tests__/ReactDOMServerPartialHydration-test.internal.js b/packages/react-dom/src/__tests__/ReactDOMServerPartialHydration-test.internal.js
index b1a88868b3389..9bd4b0cf58e24 100644
--- a/packages/react-dom/src/__tests__/ReactDOMServerPartialHydration-test.internal.js
+++ b/packages/react-dom/src/__tests__/ReactDOMServerPartialHydration-test.internal.js
@@ -9,7 +9,7 @@
 
 'use strict';
 
-let React;
+let React = require('react');
 let ReactDOM;
 let ReactDOMServer;
 let Scheduler;
@@ -70,6 +70,17 @@ function dispatchMouseEvent(to, from) {
   }
 }
 
+class TestAppClass extends React.Component {
+  render() {
+    return (
+      <div>
+        <>{''}</>
+        <>{'Hello'}</>
+      </div>
+    );
+  }
+}
+
 describe('ReactDOMServerPartialHydration', () => {
   beforeEach(() => {
     jest.resetModuleRegistry();
@@ -2738,4 +2749,49 @@ describe('ReactDOMServerPartialHydration', () => {
     expect(ref.current).toBe(span);
     expect(ref.current.innerHTML).toBe('Hidden child');
   });
+
+  function itHydratesWithoutMismatch(msg, App) {
+    it('hydrates without mismatch ' + msg, () => {
+      const container = document.createElement('div');
+      document.body.appendChild(container);
+      const finalHTML = ReactDOMServer.renderToString(<App />);
+      container.innerHTML = finalHTML;
+
+      ReactDOM.hydrateRoot(container, <App />);
+      Scheduler.unstable_flushAll();
+    });
+  }
+
+  itHydratesWithoutMismatch('an empty string with neighbors', function App() {
+    return (
+      <div>
+        <div id="test">Test</div>
+        {'' && <div>Test</div>}
+        {'Test'}
+      </div>
+    );
+  });
+
+  itHydratesWithoutMismatch('an empty string', function App() {
+    return '';
+  });
+  itHydratesWithoutMismatch(
+    'an empty string simple in fragment',
+    function App() {
+      return (
+        <>
+          {''}
+          {'sup'}
+        </>
+      );
+    },
+  );
+  itHydratesWithoutMismatch(
+    'an empty string simple in suspense',
+    function App() {
+      return <Suspense>{'' && false}</Suspense>;
+    },
+  );
+
+  itHydratesWithoutMismatch('an empty string in class component', TestAppClass);
 });
diff --git a/packages/react-dom/src/__tests__/ReactMultiChildText-test.js b/packages/react-dom/src/__tests__/ReactMultiChildText-test.js
index 2e99344289a7a..74c1d7bc3104e 100644
--- a/packages/react-dom/src/__tests__/ReactMultiChildText-test.js
+++ b/packages/react-dom/src/__tests__/ReactMultiChildText-test.js
@@ -53,6 +53,9 @@ const expectChildren = function(container, children) {
       const child = children[i];
 
       if (typeof child === 'string') {
+        if (child === '') {
+          continue;
+        }
         textNode = outerNode.childNodes[mountIndex];
         expect(textNode.nodeType).toBe(3);
         expect(textNode.data).toBe(child);
@@ -83,7 +86,7 @@ describe('ReactMultiChildText', () => {
         true, [],
         0, '0',
         1.2, '1.2',
-        '', '',
+        '', [],
         'foo', 'foo',
 
         [], [],
@@ -93,7 +96,7 @@ describe('ReactMultiChildText', () => {
         [true], [],
         [0], ['0'],
         [1.2], ['1.2'],
-        [''], [''],
+        [''], [],
         ['foo'], ['foo'],
         [<div />], [<div />],
 
diff --git a/packages/react-reconciler/src/ReactChildFiber.new.js b/packages/react-reconciler/src/ReactChildFiber.new.js
index 9071edc24f7a2..b49b8b605057d 100644
--- a/packages/react-reconciler/src/ReactChildFiber.new.js
+++ b/packages/react-reconciler/src/ReactChildFiber.new.js
@@ -488,7 +488,10 @@ function ChildReconciler(shouldTrackSideEffects) {
     newChild: any,
     lanes: Lanes,
   ): Fiber | null {
-    if (typeof newChild === 'string' || typeof newChild === 'number') {
+    if (
+      (typeof newChild === 'string' && newChild !== '') ||
+      typeof newChild === 'number'
+    ) {
       // Text nodes don't have keys. If the previous node is implicitly keyed
       // we can continue to replace it without aborting even if it is not a text
       // node.
@@ -564,7 +567,10 @@ function ChildReconciler(shouldTrackSideEffects) {
 
     const key = oldFiber !== null ? oldFiber.key : null;
 
-    if (typeof newChild === 'string' || typeof newChild === 'number') {
+    if (
+      (typeof newChild === 'string' && newChild !== '') ||
+      typeof newChild === 'number'
+    ) {
       // Text nodes don't have keys. If the previous node is implicitly keyed
       // we can continue to replace it without aborting even if it is not a text
       // node.
@@ -626,7 +632,10 @@ function ChildReconciler(shouldTrackSideEffects) {
     newChild: any,
     lanes: Lanes,
   ): Fiber | null {
-    if (typeof newChild === 'string' || typeof newChild === 'number') {
+    if (
+      (typeof newChild === 'string' && newChild !== '') ||
+      typeof newChild === 'number'
+    ) {
       // Text nodes don't have keys, so we neither have to check the old nor
       // new node for the key. If both are text nodes, they match.
       const matchedFiber = existingChildren.get(newIdx) || null;
@@ -1299,7 +1308,10 @@ function ChildReconciler(shouldTrackSideEffects) {
       throwOnInvalidObjectType(returnFiber, newChild);
     }
 
-    if (typeof newChild === 'string' || typeof newChild === 'number') {
+    if (
+      (typeof newChild === 'string' && newChild !== '') ||
+      typeof newChild === 'number'
+    ) {
       return placeSingleChild(
         reconcileSingleTextNode(
           returnFiber,
diff --git a/packages/react-reconciler/src/ReactChildFiber.old.js b/packages/react-reconciler/src/ReactChildFiber.old.js
index 0128ca8f36f3d..ad62a3445fb22 100644
--- a/packages/react-reconciler/src/ReactChildFiber.old.js
+++ b/packages/react-reconciler/src/ReactChildFiber.old.js
@@ -488,7 +488,10 @@ function ChildReconciler(shouldTrackSideEffects) {
     newChild: any,
     lanes: Lanes,
   ): Fiber | null {
-    if (typeof newChild === 'string' || typeof newChild === 'number') {
+    if (
+      (typeof newChild === 'string' && newChild !== '') ||
+      typeof newChild === 'number'
+    ) {
       // Text nodes don't have keys. If the previous node is implicitly keyed
       // we can continue to replace it without aborting even if it is not a text
       // node.
@@ -564,7 +567,10 @@ function ChildReconciler(shouldTrackSideEffects) {
 
     const key = oldFiber !== null ? oldFiber.key : null;
 
-    if (typeof newChild === 'string' || typeof newChild === 'number') {
+    if (
+      (typeof newChild === 'string' && newChild !== '') ||
+      typeof newChild === 'number'
+    ) {
       // Text nodes don't have keys. If the previous node is implicitly keyed
       // we can continue to replace it without aborting even if it is not a text
       // node.
@@ -626,7 +632,10 @@ function ChildReconciler(shouldTrackSideEffects) {
     newChild: any,
     lanes: Lanes,
   ): Fiber | null {
-    if (typeof newChild === 'string' || typeof newChild === 'number') {
+    if (
+      (typeof newChild === 'string' && newChild !== '') ||
+      typeof newChild === 'number'
+    ) {
       // Text nodes don't have keys, so we neither have to check the old nor
       // new node for the key. If both are text nodes, they match.
       const matchedFiber = existingChildren.get(newIdx) || null;
@@ -1299,7 +1308,10 @@ function ChildReconciler(shouldTrackSideEffects) {
       throwOnInvalidObjectType(returnFiber, newChild);
     }
 
-    if (typeof newChild === 'string' || typeof newChild === 'number') {
+    if (
+      (typeof newChild === 'string' && newChild !== '') ||
+      typeof newChild === 'number'
+    ) {
       return placeSingleChild(
         reconcileSingleTextNode(
           returnFiber,
diff --git a/packages/react-reconciler/src/__tests__/ReactIncrementalUpdates-test.js b/packages/react-reconciler/src/__tests__/ReactIncrementalUpdates-test.js
index b507076e9e910..ccbed48fae2b4 100644
--- a/packages/react-reconciler/src/__tests__/ReactIncrementalUpdates-test.js
+++ b/packages/react-reconciler/src/__tests__/ReactIncrementalUpdates-test.js
@@ -673,7 +673,7 @@ describe('ReactIncrementalUpdates', () => {
       root.render(<App />);
     });
     expect(Scheduler).toHaveYielded(['Committed: ']);
-    expect(root).toMatchRenderedOutput('');
+    expect(root).toMatchRenderedOutput(null);
 
     await act(async () => {
       if (gate(flags => flags.enableSyncDefaultUpdates)) {
@@ -734,7 +734,7 @@ describe('ReactIncrementalUpdates', () => {
       root.render(<App />);
     });
     expect(Scheduler).toHaveYielded([]);
-    expect(root).toMatchRenderedOutput('');
+    expect(root).toMatchRenderedOutput(null);
 
     await act(async () => {
       if (gate(flags => flags.enableSyncDefaultUpdates)) {