TITLE calcium lVA channels for DA COMMENT LOWthreshold calcium channel (L-type) ENDCOMMENT UNITS { (mM) = (milli/liter) (mV) = (millivolt) (mA) = (milliamp) (pS) =(picosiemens) FARADAY = (faraday) (coulomb) R = (k-mole) (joule/degC) } NEURON { THREADSAFE SUFFIX CAV13 USEION ca READ cai WRITE ica RANGE gbar, iLCa, ica, gbar GLOBAL qinf } PARAMETER { v (mV) dt (ms) gbar = 2 (pS/microm2) celsius Vmid_ac =-31 (mV) k_ac = 7 (mV) iLCa=0 eca = 120 (mV) cao = 2.0 (mM) cai (mM) } INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)} STATE { q } ASSIGNED { ica (mA/cm2) qinf qtau (ms) } BREAKPOINT { SOLVE states METHOD cnexp iLCa = (gbar)*q*(v-eca)*0.0001 ica = iLCa } INITIAL { settables(v) q = qinf } DERIVATIVE states { settables(v) q' = (qinf-q)/qtau } PROCEDURE settables(v) { :Computes rate and other constants at current v. :Call once from HOC to initialize inf at resting v. TABLE qinf, qtau FROM -100 TO 100 WITH 400 :"q" L Ca activation system qinf = 1.0/(1.0 + exp((Vmid_ac - v)/ k_ac)) qtau =1/((-0.20876*(v+39.26)/(exp(-(v+39.26)/4.111)-1)+(0.9444*exp(-(v+15.38)/224.1)))) }