diff --git a/Microsoft.Toolkit.Uwp.UI.Controls.Primitives/StaggeredLayout/StaggeredLayout.cs b/Microsoft.Toolkit.Uwp.UI.Controls.Primitives/StaggeredLayout/StaggeredLayout.cs
index fb94cf42878..470aad9ac96 100644
--- a/Microsoft.Toolkit.Uwp.UI.Controls.Primitives/StaggeredLayout/StaggeredLayout.cs
+++ b/Microsoft.Toolkit.Uwp.UI.Controls.Primitives/StaggeredLayout/StaggeredLayout.cs
@@ -147,14 +147,16 @@ protected override Size MeasureOverride(VirtualizingLayoutContext context, Size
             double availableWidth = availableSize.Width;
             double availableHeight = availableSize.Height;
 
-            double columnWidth = Math.Min(DesiredColumnWidth, availableWidth);
+            // This ternary prevents the column width from being NaN, which would otherwise cause an exception when measuring item sizes
+            double columnWidth = double.IsNaN(DesiredColumnWidth) ? availableWidth : Math.Min(DesiredColumnWidth, availableWidth);
             if (columnWidth != state.ColumnWidth)
             {
                 // The items will need to be remeasured
                 state.Clear();
             }
 
-            state.ColumnWidth = Math.Min(DesiredColumnWidth, availableWidth);
+            // This ternary prevents the column width from being NaN, which would otherwise cause an exception when measuring item sizes
+            state.ColumnWidth = double.IsNaN(DesiredColumnWidth) ? availableWidth : Math.Min(DesiredColumnWidth, availableWidth);
             int numColumns = Math.Max(1, (int)Math.Floor(availableWidth / state.ColumnWidth));
 
             // adjust for column spacing on all columns expect the first