From 129597ff4f086774dc6281d0e1d6dfd51de14b10 Mon Sep 17 00:00:00 2001 From: ava <99083627+avamachado@users.noreply.github.com> Date: Thu, 29 Feb 2024 11:25:26 -0600 Subject: [PATCH] Updates --- 404.html | 4 ++-- 404/index.html | 4 ++-- _gatsby/slices/_gatsby-scripts-1.html | 4 ++-- background/index.html | 4 ++-- chunk-map.json | 2 +- component---src-pages-index-js-8ad45a1e0be4490f9a4b.js | 2 ++ ...onent---src-pages-index-js-8ad45a1e0be4490f9a4b.js.map | 1 + donors/index.html | 4 ++-- experiments/index.html | 4 ++-- index.html | 8 ++++---- introduction/index.html | 4 ++-- methodology/index.html | 4 ++-- page-data/app-data.json | 2 +- preliminaries/index.html | 4 ++-- styles.59fcb9d7de25cc817545.css | 1 + webpack-runtime-f0b30841a945c00432fd.js | 2 ++ webpack-runtime-f0b30841a945c00432fd.js.map | 1 + webpack.stats.json | 2 +- 18 files changed, 32 insertions(+), 25 deletions(-) create mode 100644 component---src-pages-index-js-8ad45a1e0be4490f9a4b.js create mode 100644 component---src-pages-index-js-8ad45a1e0be4490f9a4b.js.map create mode 100644 styles.59fcb9d7de25cc817545.css create mode 100644 webpack-runtime-f0b30841a945c00432fd.js create mode 100644 webpack-runtime-f0b30841a945c00432fd.js.map diff --git a/404.html b/404.html index 88001d7..7484856 100644 --- a/404.html +++ b/404.html @@ -18,6 +18,6 @@ - \ No newline at end of file + \ No newline at end of file diff --git a/404/index.html b/404/index.html index ece732f..f6f22a9 100644 --- a/404/index.html +++ b/404/index.html @@ -18,6 +18,6 @@ - \ No newline at end of file + \ No newline at end of file diff --git a/_gatsby/slices/_gatsby-scripts-1.html b/_gatsby/slices/_gatsby-scripts-1.html index adb380f..481b82f 100644 --- a/_gatsby/slices/_gatsby-scripts-1.html +++ b/_gatsby/slices/_gatsby-scripts-1.html @@ -2,6 +2,6 @@ - \ No newline at end of file + \ No newline at end of file diff --git a/background/index.html b/background/index.html index da37095..e740a8b 100644 --- a/background/index.html +++ b/background/index.html @@ -18,6 +18,6 @@ - \ No newline at end of file + \ No newline at end of file diff --git a/chunk-map.json b/chunk-map.json index 23e6de9..a62654d 100644 --- a/chunk-map.json +++ b/chunk-map.json @@ -1 +1 @@ -{"app":["/app-23207c8981322cfd28c5.js"],"component---src-pages-404-js":["/component---src-pages-404-js-f3d403529f233e5fe989.js"],"component---src-pages-background-js":["/component---src-pages-background-js-01077f0fd65272c6f8e0.js"],"component---src-pages-donors-js":["/component---src-pages-donors-js-510e1eebaf741bdf3664.js"],"component---src-pages-index-js":["/component---src-pages-index-js-aa07fa9e70346d5e55c0.js"],"component---src-pages-markdown-remark-frontmatter-slug-js":["/component---src-pages-markdown-remark-frontmatter-slug-js-40b6b2f3369bd3e6079f.js"]} \ No newline at end of file +{"app":["/app-23207c8981322cfd28c5.js"],"component---src-pages-404-js":["/component---src-pages-404-js-f3d403529f233e5fe989.js"],"component---src-pages-background-js":["/component---src-pages-background-js-01077f0fd65272c6f8e0.js"],"component---src-pages-donors-js":["/component---src-pages-donors-js-510e1eebaf741bdf3664.js"],"component---src-pages-index-js":["/component---src-pages-index-js-8ad45a1e0be4490f9a4b.js"],"component---src-pages-markdown-remark-frontmatter-slug-js":["/component---src-pages-markdown-remark-frontmatter-slug-js-40b6b2f3369bd3e6079f.js"]} \ No newline at end of file diff --git a/component---src-pages-index-js-8ad45a1e0be4490f9a4b.js b/component---src-pages-index-js-8ad45a1e0be4490f9a4b.js new file mode 100644 index 0000000..332045c --- /dev/null +++ b/component---src-pages-index-js-8ad45a1e0be4490f9a4b.js @@ -0,0 +1,2 @@ +"use strict";(self.webpackChunkparkinsons_website=self.webpackChunkparkinsons_website||[]).push([[678],{6558:function(e,a,t){t.r(a),t.d(a,{default:function(){return c}});var i=t(7294),n=(t(4160),t(1763)),s=t(8032);function c(e){let{data:a}=e;return i.createElement(n.Z,null,i.createElement("div",{className:"page-container"},i.createElement("h1",{className:"page-title"},"Home"),i.createElement("section",{className:"section"},i.createElement("div",{className:"text-block"},i.createElement("h2",{className:"section-title"},"Overview"),i.createElement("p",null,"Parkinson's disease is a complex neurological disorder, marked by a wide array of symptoms ranging from motor impairments to cognitive changes. Our research aims to enhance early biomarker discovery for Parkinson's disease through analyzing and correlating imaging, clinical, and biological data."))),i.createElement("section",{className:"section"},i.createElement("h2",{className:"section-title"},"Early Biomarker Discovery Pipeline"),i.createElement("div",{className:"image-container"},i.createElement(s.S,{src:"../images/discovery.png",alt:"Early Biomarker Discovery Pipeline",placeholder:"blurred",__imageData:t(2733)}))),i.createElement("section",{className:"section"},i.createElement("div",{className:"content-flex"},i.createElement("div",{className:"text-block"},i.createElement("h2",{className:"section-title"},"Early Detection Primary Data"),i.createElement("p",null,"The primary data we investigated for early detection was:"),i.createElement("ol",null,i.createElement("li",null,"Variables from curated data sheet (survey results)"),i.createElement("li",null,"REM Sleep data (sleep metrics)"),i.createElement("li",null,"Biologic data including CSF (Project 171)"),i.createElement("li",null,"Imaging data (T1 MRI, DaTSCAN, DTI)"),i.createElement("li",null,"UPDRS III for state representation (Part III: Motor examination: 18 items. Score range: 0–132, 32 and below is mild, 59 and above is severe.)"))),i.createElement("div",{className:"image-container"},i.createElement(s.S,{src:"../images/primary_data.png",alt:"Table of primary data used in early detection",placeholder:"blurred",imgStyle:{objectFit:"contain",maxWidth:"100%",maxHeight:"45rem"},__imageData:t(6602)})))),i.createElement("section",{className:"section"},i.createElement("div",{className:"content-flex"},i.createElement("div",{className:"text-block"},i.createElement("h2",{className:"section-title"},"Biomarker Agent Training with DaTSCAN and T1 MRI"),i.createElement("p",null,"For the identification of imaging patterns we started out investigating T1 - MRI data"),i.createElement("ol",null,i.createElement("li",null,"T1 - MRI highlights anatomy, providing crisp structural delineation. 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\n

Home

\n\n
\n
\n

Overview

\n

\n Parkinson's disease is a complex neurological disorder, marked by\n a wide array of symptoms ranging from motor impairments to\n cognitive changes. Our research aims to enhance early biomarker\n discovery for Parkinson's disease through analyzing and correlating\n imaging, clinical, and biological data.\n

\n
\n
\n\n
\n

Early Biomarker Discovery Pipeline

\n
\n \n
\n
\n\n
\n
\n
\n

Early Detection Primary Data

\n

The primary data we investigated for early detection was:

\n
    \n
  1. Variables from curated data sheet (survey results)
    2. \n
  2. REM Sleep data (sleep metrics)
    3. \n
  3. Biologic data including CSF (Project 171)
    4. \n
  4. Imaging data (T1 MRI, DaTSCAN, DTI)
    5. \n
  5. \n UPDRS III for state representation (Part III: Motor\n examination: 18 items. Score range: 0–132, 32 and below is\n mild, 59 and above is severe.)\n
    6. \n
\n
\n
\n \n
\n
\n
\n\n
\n
\n
\n

\n Biomarker Agent Training with DaTSCAN and T1 MRI\n

\n

\n For the identification of imaging patterns we started out\n investigating T1 - MRI data\n

\n
    \n
  1. \n T1 - MRI highlights anatomy, providing crisp structural\n delineation. Volumes from T1- MRI for 112 prespecified regions\n were extracted for each patient\n
    2. \n
  2. \n DaTSCAN images visualize striatal dopamine transporter\n intensity; commonly known to be a biomarker for PD. We utilize\n it to make improvement on SBR ratio extraction.\n
    3. \n
\n
\n
\n \n
\n
\n
\n\n
\n
\n
\n

\n Biomarker Agent Training with DTI, T2 MRI, and fMRI\n

\n
    \n
  1. \n DTI images detect the diffusion of water molecules in the\n white matter of the brain. We begin by extracting mean\n diffusivity and fractional anisotropy from 112 regions\n
      \n
    • Substantia Nigra is the ROI based on literature
      • \n
    • Will be investigated when T2 MRI is integrated
      • \n
    \n
    2. \n
  2. \n This will eventually branch out into combining MRI with other\n imaging types such as T2-MRI and fMRI\n
    3. \n
\n
\n
\n \n
\n
\n
\n
\n \n );\n}\n\nexport const query = graphql`\n query {\n allMarkdownRemark {\n edges {\n node {\n id\n frontmatter {\n title\n slug\n id\n }\n }\n }\n }\n }\n`;\n"],"names":["IndexPage","_ref","data","React","Layout","className","StaticImage","src","alt","placeholder","__imageData","require","imgStyle","objectFit","maxWidth","maxHeight"],"sourceRoot":""} \ No newline at end of file diff --git a/donors/index.html b/donors/index.html index 751b8a8..df5737a 100644 --- a/donors/index.html +++ b/donors/index.html @@ -18,6 +18,6 @@ - \ No newline at end of file + \ No newline at end of file diff --git a/experiments/index.html b/experiments/index.html index c20fd8c..3fa6d35 100644 --- a/experiments/index.html +++ b/experiments/index.html @@ -93,6 +93,6 @@

Analysis of Extracted SBR ratios

- \ No newline at end of file + \ No newline at end of file diff --git a/index.html b/index.html index 6b0f6cb..94fdec3 100644 --- a/index.html +++ b/index.html @@ -1,4 +1,4 @@ -

Quick and Efficient Extraction of Patient Specific SBR Ratios for Parkinson’s Disease

Home

Overview

Parkinson's disease is a complex neurological disorder, marked by a wide array of symptoms ranging from motor impairments to cognitive changes. Our research aims to enhance early biomarker discovery for Parkinson's disease through analyzing and correlating imaging, clinical, and biological data.

Early Biomarker Discovery Pipeline

Early Biomarker Discovery Pipeline

Early Detection Primary Data

The primary data we investigated for early detection was:

  1. Variables from curated data sheet (survey results)
  2. REM Sleep data (sleep metrics)
  3. Biologic data including CSF (Project 171)
  4. Imaging data (T1 MRI, DaTSCAN, DTI)
  5. UPDRS III for state representation (Part III: Motor examination: 18 items. Score range: 0–132, 32 and below is mild, 59 and above is severe.)
Table of primary data used in early detection

Biomarker Agent Training with DaTSCAN and T1 MRI

For the identification of imaging patterns we started out investigating T1 - MRI data

  1. T1 - MRI highlights anatomy, providing crisp structural delineation. Volumes from T1- MRI for 112 prespecified regions were extracted for each patient
  2. DaTSCAN images visualize striatal dopamine transporter intensity; commonly known to be a biomarker for PD. We utilize it to make improvement on SBR ratio extraction.
Diagram pointing to different sections of the brain

Biomarker Agent Training with DTI, T2 MRI, and fMRI

  1. DTI images detect the diffusion of water molecules in the white matter of the brain. We begin by extracting mean diffusivity and fractional anisotropy from 112 regions
    • Substantia Nigra is the ROI based on literature
    • Will be investigated when T2 MRI is integrated
  2. This will eventually branch out into combining MRI with other imaging types such as T2-MRI and fMRI
DTI images with overlays
+

Quick and Efficient Extraction of Patient Specific SBR Ratios for Parkinson’s Disease

Home

Overview

Parkinson's disease is a complex neurological disorder, marked by a wide array of symptoms ranging from motor impairments to cognitive changes. Our research aims to enhance early biomarker discovery for Parkinson's disease through analyzing and correlating imaging, clinical, and biological data.

Early Biomarker Discovery Pipeline

Early Biomarker Discovery Pipeline

Early Detection Primary Data

The primary data we investigated for early detection was:

  1. Variables from curated data sheet (survey results)
  2. REM Sleep data (sleep metrics)
  3. Biologic data including CSF (Project 171)
  4. Imaging data (T1 MRI, DaTSCAN, DTI)
  5. UPDRS III for state representation (Part III: Motor examination: 18 items. Score range: 0–132, 32 and below is mild, 59 and above is severe.)
Table of primary data used in early detection

Biomarker Agent Training with DaTSCAN and T1 MRI

For the identification of imaging patterns we started out investigating T1 - MRI data

  1. T1 - MRI highlights anatomy, providing crisp structural delineation. Volumes from T1- MRI for 112 prespecified regions were extracted for each patient
  2. DaTSCAN images visualize striatal dopamine transporter intensity; commonly known to be a biomarker for PD. We utilize it to make improvement on SBR ratio extraction.
Diagram pointing to different sections of the brain

Biomarker Agent Training with DTI, T2 MRI, and fMRI

  1. DTI images detect the diffusion of water molecules in the white matter of the brain. We begin by extracting mean diffusivity and fractional anisotropy from 112 regions
    • Substantia Nigra is the ROI based on literature
    • Will be investigated when T2 MRI is integrated
  2. This will eventually branch out into combining MRI with other imaging types such as T2-MRI and fMRI
DTI images with overlays
- \ No newline at end of file + \ No newline at end of file diff --git a/introduction/index.html b/introduction/index.html index 5bee30e..f5919ab 100644 --- a/introduction/index.html +++ b/introduction/index.html @@ -25,6 +25,6 @@

References

- \ No newline at end of file + \ No newline at end of file diff --git a/methodology/index.html b/methodology/index.html index 6f81131..ef62a89 100644 --- a/methodology/index.html +++ b/methodology/index.html @@ -126,6 +126,6 @@

References

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) 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