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diff --git a/component---src-pages-index-js-8ad45a1e0be4490f9a4b.js b/component---src-pages-index-js-8ad45a1e0be4490f9a4b.js
new file mode 100644
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Our research aims to enhance early biomarker discovery for Parkinson's disease through analyzing and correlating imaging, clinical, and biological data."))),i.createElement("section",{className:"section"},i.createElement("h2",{className:"section-title"},"Early Biomarker Discovery Pipeline"),i.createElement("div",{className:"image-container"},i.createElement(s.S,{src:"../images/discovery.png",alt:"Early Biomarker Discovery Pipeline",placeholder:"blurred",__imageData:t(2733)}))),i.createElement("section",{className:"section"},i.createElement("div",{className:"content-flex"},i.createElement("div",{className:"text-block"},i.createElement("h2",{className:"section-title"},"Early Detection Primary Data"),i.createElement("p",null,"The primary data we investigated for early detection was:"),i.createElement("ol",null,i.createElement("li",null,"Variables from curated data sheet (survey results)"),i.createElement("li",null,"REM Sleep data (sleep metrics)"),i.createElement("li",null,"Biologic data including CSF (Project 171)"),i.createElement("li",null,"Imaging data (T1 MRI, DaTSCAN, DTI)"),i.createElement("li",null,"UPDRS III for state representation (Part III: Motor examination: 18 items. Score range: 0–132, 32 and below is mild, 59 and above is severe.)"))),i.createElement("div",{className:"image-container"},i.createElement(s.S,{src:"../images/primary_data.png",alt:"Table of primary data used in early detection",placeholder:"blurred",imgStyle:{objectFit:"contain",maxWidth:"100%",maxHeight:"45rem"},__imageData:t(6602)})))),i.createElement("section",{className:"section"},i.createElement("div",{className:"content-flex"},i.createElement("div",{className:"text-block"},i.createElement("h2",{className:"section-title"},"Biomarker Agent Training with DaTSCAN and T1 MRI"),i.createElement("p",null,"For the identification of imaging patterns we started out investigating T1 - MRI data"),i.createElement("ol",null,i.createElement("li",null,"T1 - MRI highlights anatomy, providing crisp structural delineation. Volumes from T1- MRI for 112 prespecified regions were extracted for each patient"),i.createElement("li",null,"DaTSCAN images visualize striatal dopamine transporter intensity; commonly known to be a biomarker for PD. We utilize it to make improvement on SBR ratio extraction."))),i.createElement("div",{className:"image-container"},i.createElement(s.S,{src:"../images/brain_diagram.png",alt:"Diagram pointing to different sections of the brain",placeholder:"blurred",imgStyle:{objectFit:"contain",maxWidth:"100%",maxHeight:"45rem"},__imageData:t(79)})))),i.createElement("section",{className:"section"},i.createElement("div",{className:"content-flex"},i.createElement("div",{className:"text-block"},i.createElement("h2",{className:"section-title"},"Biomarker Agent Training with DTI, T2 MRI, and fMRI"),i.createElement("ol",null,i.createElement("li",null,"DTI images detect the diffusion of water molecules in the white matter of the brain. We begin by extracting mean diffusivity and fractional anisotropy from 112 regions",i.createElement("ul",null,i.createElement("li",null,"Substantia Nigra is the ROI based on literature"),i.createElement("li",null,"Will be investigated when T2 MRI is integrated"))),i.createElement("li",null,"This will eventually branch out into combining MRI with other imaging types such as T2-MRI and fMRI"))),i.createElement("div",{className:"image-container"},i.createElement(s.S,{src:"../images/dti_images.png",alt:"DTI images with 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Our research aims to enhance early biomarker\n              discovery for Parkinson's disease through analyzing and correlating\n              imaging, clinical, and biological data.\n            </p>\n          </div>\n        </section>\n\n        <section className=\"section\">\n          <h2 className=\"section-title\">Early Biomarker Discovery Pipeline</h2>\n          <div className=\"image-container\">\n          <StaticImage\n            src=\"../images/discovery.png\"\n            alt=\"Early Biomarker Discovery Pipeline\"\n            placeholder=\"blurred\"\n          />\n          </div>\n        </section>\n\n        <section className=\"section\">\n          <div className=\"content-flex\">\n            <div className=\"text-block\">\n              <h2 className=\"section-title\">Early Detection Primary Data</h2>\n              <p>The primary data we investigated for early detection was:</p>\n              <ol>\n                <li>Variables from curated data sheet (survey results)</li>\n                <li>REM Sleep data (sleep metrics)</li>\n                <li>Biologic data including CSF (Project 171)</li>\n                <li>Imaging data (T1 MRI, DaTSCAN, DTI)</li>\n                <li>\n                  UPDRS III for state representation (Part III: Motor\n                  examination: 18 items. Score range: 0–132, 32 and below is\n                  mild, 59 and above is severe.)\n                </li>\n              </ol>\n            </div>\n            <div className=\"image-container\">\n              <StaticImage\n                src=\"../images/primary_data.png\"\n                alt=\"Table of primary data used in early detection\"\n                placeholder=\"blurred\"\n                imgStyle = {{ objectFit: 'contain', maxWidth: '100%', maxHeight: '45rem' }}\n              />\n            </div>\n          </div>\n        </section>\n\n        <section className=\"section\">\n          <div className=\"content-flex\">\n            <div className=\"text-block\">\n              <h2 className=\"section-title\">\n                Biomarker Agent Training with DaTSCAN and T1 MRI\n              </h2>\n              <p>\n                For the identification of imaging patterns we started out\n                investigating T1 - MRI data\n              </p>\n              <ol>\n                <li>\n                  T1 - MRI highlights anatomy, providing crisp structural\n                  delineation. Volumes from T1- MRI for 112 prespecified regions\n                  were extracted for each patient\n                </li>\n                <li>\n                  DaTSCAN images visualize striatal dopamine transporter\n                  intensity; commonly known to be a biomarker for PD. We utilize\n                  it to make improvement on SBR ratio extraction.\n                </li>\n              </ol>\n            </div>\n            <div className=\"image-container\">\n              <StaticImage\n                src=\"../images/brain_diagram.png\"\n                alt=\"Diagram pointing to different sections of the brain\"\n                placeholder=\"blurred\"\n                imgStyle = {{ objectFit: 'contain', maxWidth: '100%', maxHeight: '45rem' }}\n              />\n            </div>\n          </div>\n        </section>\n\n        <section className=\"section\">\n          <div className=\"content-flex\">\n            <div className=\"text-block\">\n              <h2 className=\"section-title\">\n                Biomarker Agent Training with DTI, T2 MRI, and fMRI\n              </h2>\n              <ol>\n                <li>\n                  DTI images detect the diffusion of water molecules in the\n                  white matter of the brain. We begin by extracting mean\n                  diffusivity and fractional anisotropy from 112 regions\n                  <ul>\n                    <li>Substantia Nigra is the ROI based on literature</li>\n                    <li>Will be investigated when T2 MRI is integrated</li>\n                  </ul>\n                </li>\n                <li>\n                  This will eventually branch out into combining MRI with other\n                  imaging types such as T2-MRI and fMRI\n                </li>\n              </ol>\n            </div>\n            <div className=\"image-container\">\n              <StaticImage\n                src=\"../images/dti_images.png\"\n                alt=\"DTI images with overlays\"\n                placeholder=\"blurred\"\n                imgStyle = {{ objectFit: 'contain', maxWidth: '100%', maxHeight: '45rem' }}\n              />\n            </div>\n          </div>\n        </section>\n      </div>\n    </Layout>\n  );\n}\n\nexport const query = graphql`\n  query {\n    allMarkdownRemark {\n      edges {\n        node {\n          id\n          frontmatter {\n            title\n            slug\n            id\n          }\n        }\n      }\n    }\n  }\n`;\n"],"names":["IndexPage","_ref","data","React","Layout","className","StaticImage","src","alt","placeholder","__imageData","require","imgStyle","objectFit","maxWidth","maxHeight"],"sourceRoot":""}
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diff --git a/experiments/index.html b/experiments/index.html
index c20fd8c..3fa6d35 100644
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diff --git a/index.html b/index.html
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+++ b/index.html
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) 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yEoSnTgEuaj6UjAvV5Pr+BifSrkRtjZ2eO7Mp6xIIHlpyAbPksZi8T5+fndCZKt/5wo/Obk08LA422lLpkLlUt/Rpm67w7d2nHKwPhZYZi8TV5vNeJ1AlAsPS3e9Jgvwk12PxTIEXQVwCZdeL4dnldeN4HdIqUZovD5dOa3uS4X/lsseVHabaKE7Y0llJqOWpvDdiy1Qx/c0qR7pxMIbgpvNvnHDQSPT9CIeJh1udKzMTnZ+mhM4I58bqV5RWxM1wudFMBleUAkUjqkZ9wvXjM3+hM0P528Y+d7DFU2Tmyyn64H5Tc21JVntGsi310neo9iVjBQ2EhZDQva++CVXcF3layeiqqEH1LNXQUP2sup2iTwuANGs1yvzPNnNLd/kPEgiE9DBQ/JKovgGGgfuul1Gc/CXZPSyIwy5X30y79EDXD1WYlqXJlyUIOV7Y28Z0H7ftn/jZaYkoTNEKDC1sWc+eP3lcJr1xAtuYU6xyXZNbdg9+lBD4d28OZp7OUGryH0hMqWFRWcFpGxQCLhP7zeZal5MW54m361L8qztdKFHbSXGZSMr/WT4a0MvfEe/9FKhX+Hodl3I5+CKkHqiCwYlkmqL0CBcaO3Y6bFi4EecT4Yd18fvWt7oC9JnCjNFQOmPkfTbTlcyXfspAgmO1OdnHTSe8VhVD8eiCqMyEmgS9aJl3hn2zo0fCZuLSct+VxhR3Z4d8uU8ydPpvBL/znQ3buicBE4MhVI4MdboSArMIHplwakaT8aK8d8fePsUti19lX2ECjMlCit3/aTk48+6D814Qaq5MAbNTV8L5qH+sxhSyvKl14D81Y1hkKT+7LLPE+qCVxcMc7A5ZDtg/UC9Icp4eu/cExWfCM0MX+63Vz8GrMQET1uowbfbIiDuWzdjS2BHoFmRN9McZ7dpFargNaKv3KtZUhOTfe05yiRBNmW5CHQSatOeD+BB+MsxwvyNGM4QmuZsAKwCGOGX1aydJ0Hw2ZYb7B1VuAy5S1XTm7eHf+ckgv9+/33uGsDBCUVyocbAqM+HDRUv600duBvKZdLs4uc5nRxkMBaYDuhXL6KwPQs/7mI81LfIeedcXiry1A2j8sLWtdxYC8zvTRfzXGdal8jzV+O7+6Mdb+uOH1cLgdKPuE8rW/fyjlQVJxaLIVFeU7vFXsgLhI8P2nGf/r2xPAmpLRJrCFJoz/ZlCkNEZ4xu/tQbFzy6CuGxVAbPOq95vg3mqIg3sSBPQVwrANbYpfqs04wkPkRli3/NjFf4f69oe5kqMw/qfQKmTmxtGXZcJrSheVV2xOXYr4bd5QebvfJKD2X0mpGayqBhTykDG9USYDml+3/JiWrJiv+oCW+71BvsdpUVg8aHy118Z2qTx8g6ui1HeVLgwtFhcIv7Avt3btylBysYh2Whj3umPYmW3tlBUfvH9ylEpyWGwvw/U5gsyjXv9CyjH7vy8Ogzaj0TZyniErP4W8ONy0HVnNdnO8HTvk4EH7n+WSIPSUrVjpvwgf0S5aISYTL/XEoBOT8iKxNHuCi82wYq9Wey84sC9vr/to5DRcRp9DXVaEpdXNHv7hbRsuCi/2oZifS0GlzR11HfD1WuaFfalQUMT4jEK82opF9MD3vTRaXHa2v09evclx37JgYpVJHqB6pSQ8lN9dCTPnXe/Jo3yZH4ueRsTOr6fz6Gr3ZY97sPBSwILE/npykHtNOMW09T6wDwM+hFmDbL9z8wis6177Ikin4khD4Lvs0CgAKqaRXjvAWOSsdKn2divG+wByXRqZ9h264JvZ6L55wuLBmtSxEneLfsOdxhckriwK9/GjS+mMGa9KTNhwlDORrcF5TFpuknns8yt25j1GDU3zyGItxftrh4nShK43EWJLanCscBIVtLUkW9BAY52KpMMGSXNPGuf+7NAyo36jUqoj36z0EpXYM4gx7hpj9ZFpUOiYD6E7+qclEPrcZ3Uelss12YrvKTfFfxu6Nq34YajchtKO99GerPRYH+QS7XAvyh08wZP9ZiS0tRUt1tcOk6TcTs3xvhr030BCzt1ZrI+KGC0MmBsb357SMKGqkzWY5XLWeFYRDGI5vEHCyMc/i7RFXWCuIJyih21aQM8HzZBM/zYnLrqZ7F+x1e12hIVjc8iCfy7wOOLHflARHi1oaDgiCEnud8wOlCcxVdk5xbUsxNvhbFMRMIbcLhUz9di+wyVaJeS/H707B+XSCbrvjuxVLRNwbQUfiSoDGXaEGDjsr2GsyoRinLQC5NOiPkmoXO5GFQoFb9W/JGfvKQ+Bd7Zr5FqMUfk/9L78lxMUYCVFeccuZ1DEpA0kiN59yqOVBdLEh0sP+dwY6K3cV4My3iSP7ywKXFyX3RWsjbq1IhaxGS4P1vt9KsQYz5BsbWT9VnXVaRI1RiY4O1B1gr5pHjmwbQxjniaFf1s5CcvHoP9y8/fH9bUAVVQx1lpqTZZF7uFxWHSxmuy+AnisK/sH0J5c3nVrZc+DeXT9C13gy9jHK522zedsXWbvkElLh4hcao3RAYHabzivlBnRM7+aqHaX6MVCxPMB7+IHld0SZ4VtOG5lWGrzpnwu20w8hdhNuzmhHQvfcPhstNLdcGkaKYowTQMavI7FjW53X6zf2LzOsPaTN47ydjoBcaG7+cJuCMcUeQlVDLA/UkWsaMw+/8MRp2EALdRTeULDsaEE8qbP5ESYdaXVuJRsCuIGSGcsnBPSkF1QWlGURZISFHFEHtP1K2w/G9nIxwuKhkgOQqPX5c0o6uGNxbkFg7tLWxZWLja0YbBOjGScVtA6OKFye737J9AzYOQ1K5NXuWRXMWnMsKW+mUWyj0SmkuqJFvOga2LJ3xVhkAJ9M/sT3lJsC54lf4jUTyJLeZkDRDl3IFyO1GmyNlg4KCuWlEnn0Cg4x5ruNKcuaIZG88QoDTw1qLSk3wWNZVDcIcV0o0ypc9vzITwWTnzaSC9mDEQe82H1v+9ldmHbYUFycLPf+An0ZIZKJYWCtLHZ7cm9vBZWjncC+saN/4tlu6X6WetCrs7N+8mSJ/St+4kdxOEZieRLGag1p1rdef1SFhgAgMaN7TWtGAT1wr8xmJLhbojWXRq6sF45URZ88Kvm5pT0hbU9VowkVBmcRjEIxId25VI25g5nBn7N5JX44rgfV0c1z1t4azjaCAbJ5ZvnTs0rd/yfhsmju4e/LGmacI76SQnIxWX6/Tray4+3sRn0pE5yonxj0GKbnTjLszhOHyfTyYWt1TXrQHZH44IYW44gM+WorTFQN+EwU6Pi4qsY+TQ1ULmyuz3y7MINgOSif+ITi8mF6lDaxn1uFm5KgUFHoB5dDacCO06khoXLYZs/ociVKDoEKLZEYfdixjTUYzQzhI6TKijuNohCCWgzriiRDaoY7Q6D9R+gGYAOowVOtVCm5k610fzQR1E076QE6kjMN9/HAFzaK7J93mYroIT+RvGgb8EAMA43brzr6uNfsxOpBMWhvmY0DS6MVOgGDkAtf/f08jmd9mJqPzNJjrAFfx9EfCcskVUcQCiCQNk3Mz35G8vR8DS8PLOj21n7m/KDqLeAfIF5WeTC+84clZdzUxk5ci8qevKH6ol3WvSbghqLVVP6Pwd5gCg0hc0vXRKzJvj9YnhbAxdYGCLAQDAZoBsIkht80QI2+WJsGwPJyJsp51I44z8XdHxiaxGV6y8WbaghwMu7ToM6tKoXoMeFINqvjKxsbBaGKOErWVpilutbh1uy5hjAtZyteAAwyYNx2niYLRVENo5BbUe4xibeNSUkVaDUjTMfahQBZe0mPVip0cHN55JtlqDewH25KXjtWvT88pd3ta6taYkXmk4yuwejLsdrcn5qu2Cy2lPrEycIxTuObgO5d5g2410tQFk+5Q/nnYmgXzpOVABOzJXi9T/MGLSyhOSBk2SB/QidP+QaL5EbslxV7Pybp7t5gFwQKn1awzPUgDbbli5T8yrQRE9JSWdR+v2k0ulWcPlSnfvNsY5CtZx/4FdPqVYELYaSuzGGuy1NSFZKkhbayRJkhqqGTp0Nnewe6ohDNiGAvFNAW7d/QjFo8/bxhLrrNKyKwWT9TiuxcqSZT3C4ZR5kTsCm1mtWzWV3JFNtKYgelqA//ibZYiXqhtB7l5ydKqy6Vb9R/Rl09LR82Hgy4+/AEYm5hL6tW0CBQkWIpRdmHARIkUdRO+tGi33X1tUygu4vu4OgOD88gv8m32jPgDQ/+4a8nsz/0ogIL4ZRboRbPmBHWPMTBWG5gKnfCMY4D5rddbudr/jvVAONcpQPY4BG5rYKGXJ3OVOYpOALXxm9eUEujvRITYCsv1eeHQ6muad3bXklVbTAdwFAAA=) 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alt="Logo" class="header-logo"/></a><div class="title-container"><h1><a aria-current="page" style="color:white;text-decoration:none" class="" href="/parkinsons-website/">Quick and Efficient Extraction of Patient Specific SBR Ratios for Parkinson’s Disease</a></h1></div></div><div class="navbar-container"><nav><ul class="navbar-list"><li style="list-style-type:none;padding-left:1rem;padding-right:1rem"><a aria-current="page" style="text-decoration:none" class="" href="/parkinsons-website/">Home</a></li><li style="list-style-type:none;padding-left:1rem;padding-right:1rem"><a style="text-decoration:none" href="/parkinsons-website/background/">Background</a></li><li style="list-style-type:none;padding-left:1rem;padding-right:1rem"><a style="text-decoration:none" href="/parkinsons-website/donors/">Donors</a></li></ul></nav></div></div></header><div class="content-container"><div class="page-container"><h1 class="page-title">Home</h1><section class="section"><div class="text-block"><h2 class="section-title">Overview</h2><p>Parkinson&#x27;s disease is a complex neurological disorder, marked by a wide array of symptoms ranging from motor impairments to cognitive changes. Our research aims to enhance early biomarker discovery for Parkinson&#x27;s disease through analyzing and correlating imaging, clinical, and biological data.</p></div></section><section class="section"><h2 class="section-title">Early Biomarker Discovery Pipeline</h2><div class="image-container"><div data-gatsby-image-wrapper="" class="gatsby-image-wrapper gatsby-image-wrapper-constrained"><div style="max-width:3080px;display:block"><img alt="" role="presentation" aria-hidden="true" src="data:image/svg+xml;charset=utf-8,%3Csvg%20height=&#x27;1792&#x27;%20width=&#x27;3080&#x27;%20xmlns=&#x27;http://www.w3.org/2000/svg&#x27;%20version=&#x27;1.1&#x27;%3E%3C/svg%3E" style="max-width:100%;display:block;position:static"/></div><img aria-hidden="true" data-placeholder-image="" style="opacity:1;transition:opacity 500ms linear" decoding="async" src="data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABQAAAAMCAYAAABiDJ37AAAACXBIWXMAABYlAAAWJQFJUiTwAAACoElEQVR42nWTa2/iZhCF+f8/Y/uBKqq21W5ICAlpk2y4E8AJ2NyCQxwMBnzjahv76UDUdr90pKN5Zb3vmTNnxqk4joGEmR1QUl0yd21yhT7ZHxr3jQn2OiHZWEzVBzrFS+a9AvHO5fhqMFEptO4oKPcMTI04iUm5rkcY7HizArKVBWe5Dte1OXfPPrctn4kjT70xnpqneZNm1sgQr+eEIqRjNPmzecV1NUPno0V0CEklfMbCD3l+9ejoPsNpJBVDNGOLu45ItjbhvEe0GBJYXaKtz0EIp67Bh6Nj2DqmY3A4HEgFQSgdx3jrgJq24Km7pC65plq0hh6ObeOM6lj9CvNBlUW/zNbsMXNMnkcNEaDQ1luoY4WFNyPleT5RFGCLwrOcypfzJunLF758r3NRnOA5Lq+lP2jl03TuzlBufmEppGNL59v9b5w//E5GcP74lXf59m/L/iakb2wYzUJBwOt0L6bv8KVgYL8RCQ7OmNAesXc+xApX/H1ntpoITD7sd+nSFcLkk9JcBjwoc3KPfW5KI/JlncKLw3KVsJPLWjFDv5JDK3xnbb2dptzoVrgtXcndLM1BTXw9/KdQF0UXMuX0hcKv2TZXVUumvGZix8Ri/Fy5RLlNn3K01NlHIcq4Sq5yTrb4jRfjiX24J8VPLY9nOybLkKHhMZqsMOZ7NvsD8X5FKFPcLPRTjne+7FyC5ZqMp69Ynuzrak58VMj/RCg75a/9Uxv/hCM7+/kjgLtasdkFJ+KfI7Xbbk9+7JdLfFXFUTVcTcPrdlm223JW0StlBsUC3ccfuHJnOxzgdzU2ko9Y9bpsjHeO1Kk3XfwIQ3amiXn/F73ra7SrLFo2SzeXY5DPY5WKLMolQRmvXsN/quM3nvCOWeBVK6ykwJHwb6Hpbw/jo4TXAAAAAElFTkSuQmCC" alt=""/><picture><source type="image/webp" data-srcset="/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/68949/discovery.webp 770w,/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/bef8e/discovery.webp 1540w,/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/cd4db/discovery.webp 3080w" sizes="(min-width: 3080px) 3080px, 100vw"/><img data-gatsby-image-ssr="" data-main-image="" style="opacity:0" sizes="(min-width: 3080px) 3080px, 100vw" decoding="async" loading="lazy" data-src="/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/dc1c9/discovery.png" data-srcset="/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/e81d0/discovery.png 770w,/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/f063b/discovery.png 1540w,/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/dc1c9/discovery.png 3080w" alt="Early Biomarker Discovery Pipeline"/></picture><noscript><picture><source type="image/webp" srcSet="/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/68949/discovery.webp 770w,/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/bef8e/discovery.webp 1540w,/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/cd4db/discovery.webp 3080w" sizes="(min-width: 3080px) 3080px, 100vw"/><img data-gatsby-image-ssr="" data-main-image="" style="opacity:0" sizes="(min-width: 3080px) 3080px, 100vw" decoding="async" loading="lazy" src="/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/dc1c9/discovery.png" srcSet="/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/e81d0/discovery.png 770w,/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/f063b/discovery.png 1540w,/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/dc1c9/discovery.png 3080w" alt="Early Biomarker Discovery Pipeline"/></picture></noscript><script type="module">const t="undefined"!=typeof HTMLImageElement&&"loading"in HTMLImageElement.prototype;if(t){const t=document.querySelectorAll("img[data-main-image]");for(let e of t){e.dataset.src&&(e.setAttribute("src",e.dataset.src),e.removeAttribute("data-src")),e.dataset.srcset&&(e.setAttribute("srcset",e.dataset.srcset),e.removeAttribute("data-srcset"));const t=e.parentNode.querySelectorAll("source[data-srcset]");for(let e of t)e.setAttribute("srcset",e.dataset.srcset),e.removeAttribute("data-srcset");e.complete&&(e.style.opacity=1,e.parentNode.parentNode.querySelector("[data-placeholder-image]").style.opacity=0)}}</script></div></div></section><section class="section"><div class="content-flex"><div class="text-block"><h2 class="section-title">Early Detection Primary Data</h2><p>The primary data we investigated for early detection was:</p><ol><li>Variables from curated data sheet (survey results)</li><li>REM Sleep data (sleep metrics)</li><li>Biologic data including CSF (Project 171)</li><li>Imaging data (T1 MRI, DaTSCAN, DTI)</li><li>UPDRS III for state representation (Part III: Motor examination: 18 items. Score range: 0–132, 32 and below is mild, 59 and above is severe.)</li></ol></div><div class="image-container"><div data-gatsby-image-wrapper="" class="gatsby-image-wrapper gatsby-image-wrapper-constrained"><div style="max-width:2438px;display:block"><img alt="" role="presentation" aria-hidden="true" src="data:image/svg+xml;charset=utf-8,%3Csvg%20height=&#x27;923.9999999999999&#x27;%20width=&#x27;2438&#x27;%20xmlns=&#x27;http://www.w3.org/2000/svg&#x27;%20version=&#x27;1.1&#x27;%3E%3C/svg%3E" style="max-width:100%;display:block;position:static"/></div><img aria-hidden="true" data-placeholder-image="" style="opacity:1;transition:opacity 500ms linear" decoding="async" src="data:image/png;base64,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" alt=""/><picture><source type="image/webp" data-srcset="/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/db70c/primary_data.webp 610w,/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/c89b3/primary_data.webp 1219w,/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/7d093/primary_data.webp 2438w" sizes="(min-width: 2438px) 2438px, 100vw"/><img data-gatsby-image-ssr="" data-main-image="" style="opacity:0" sizes="(min-width: 2438px) 2438px, 100vw" decoding="async" loading="lazy" data-src="/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/e7af3/primary_data.png" data-srcset="/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/9cfe5/primary_data.png 610w,/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/9034e/primary_data.png 1219w,/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/e7af3/primary_data.png 2438w" alt="Table of primary data used in early detection"/></picture><noscript><picture><source type="image/webp" srcSet="/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/db70c/primary_data.webp 610w,/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/c89b3/primary_data.webp 1219w,/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/7d093/primary_data.webp 2438w" sizes="(min-width: 2438px) 2438px, 100vw"/><img data-gatsby-image-ssr="" data-main-image="" style="opacity:0" sizes="(min-width: 2438px) 2438px, 100vw" decoding="async" loading="lazy" src="/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/e7af3/primary_data.png" srcSet="/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/9cfe5/primary_data.png 610w,/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/9034e/primary_data.png 1219w,/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/e7af3/primary_data.png 2438w" alt="Table of primary data used in early detection"/></picture></noscript><script type="module">const t="undefined"!=typeof HTMLImageElement&&"loading"in HTMLImageElement.prototype;if(t){const t=document.querySelectorAll("img[data-main-image]");for(let e of t){e.dataset.src&&(e.setAttribute("src",e.dataset.src),e.removeAttribute("data-src")),e.dataset.srcset&&(e.setAttribute("srcset",e.dataset.srcset),e.removeAttribute("data-srcset"));const t=e.parentNode.querySelectorAll("source[data-srcset]");for(let e of t)e.setAttribute("srcset",e.dataset.srcset),e.removeAttribute("data-srcset");e.complete&&(e.style.opacity=1,e.parentNode.parentNode.querySelector("[data-placeholder-image]").style.opacity=0)}}</script></div></div></div></section><section class="section"><div class="content-flex"><div class="text-block"><h2 class="section-title">Biomarker Agent Training with DaTSCAN and T1 MRI</h2><p>For the identification of imaging patterns we started out investigating T1 - MRI data</p><ol><li>T1 - MRI highlights anatomy, providing crisp structural delineation. Volumes from T1- MRI for 112 prespecified regions were extracted for each patient</li><li>DaTSCAN images visualize striatal dopamine transporter intensity; commonly known to be a biomarker for PD. We utilize it to make improvement on SBR ratio extraction.</li></ol></div><div class="image-container"><div data-gatsby-image-wrapper="" class="gatsby-image-wrapper gatsby-image-wrapper-constrained"><div style="max-width:1360px;display:block"><img alt="" role="presentation" aria-hidden="true" src="data:image/svg+xml;charset=utf-8,%3Csvg%20height=&#x27;1646&#x27;%20width=&#x27;1360&#x27;%20xmlns=&#x27;http://www.w3.org/2000/svg&#x27;%20version=&#x27;1.1&#x27;%3E%3C/svg%3E" style="max-width:100%;display:block;position:static"/></div><img aria-hidden="true" data-placeholder-image="" style="opacity:1;transition:opacity 500ms linear" decoding="async" 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HTMLImageElement&&"loading"in HTMLImageElement.prototype;if(t){const t=document.querySelectorAll("img[data-main-image]");for(let e of t){e.dataset.src&&(e.setAttribute("src",e.dataset.src),e.removeAttribute("data-src")),e.dataset.srcset&&(e.setAttribute("srcset",e.dataset.srcset),e.removeAttribute("data-srcset"));const t=e.parentNode.querySelectorAll("source[data-srcset]");for(let e of t)e.setAttribute("srcset",e.dataset.srcset),e.removeAttribute("data-srcset");e.complete&&(e.style.opacity=1,e.parentNode.parentNode.querySelector("[data-placeholder-image]").style.opacity=0)}}</script></div></div></div></section><section class="section"><div class="content-flex"><div class="text-block"><h2 class="section-title">Biomarker Agent Training with DTI, T2 MRI, and fMRI</h2><ol><li>DTI images detect the diffusion of water molecules in the white matter of the brain. We begin by extracting mean diffusivity and fractional anisotropy from 112 regions<ul><li>Substantia Nigra is the ROI based on literature</li><li>Will be investigated when T2 MRI is integrated</li></ul></li><li>This will eventually branch out into combining MRI with other imaging types such as T2-MRI and fMRI</li></ol></div><div class="image-container"><div data-gatsby-image-wrapper="" class="gatsby-image-wrapper gatsby-image-wrapper-constrained"><div style="max-width:1574px;display:block"><img alt="" role="presentation" aria-hidden="true" src="data:image/svg+xml;charset=utf-8,%3Csvg%20height=&#x27;1816&#x27;%20width=&#x27;1574&#x27;%20xmlns=&#x27;http://www.w3.org/2000/svg&#x27;%20version=&#x27;1.1&#x27;%3E%3C/svg%3E" style="max-width:100%;display:block;position:static"/></div><img aria-hidden="true" data-placeholder-image="" style="opacity:1;transition:opacity 500ms linear" decoding="async" 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" alt="Logo" class="header-logo"/></a><div class="title-container"><h1><a aria-current="page" style="color:white;text-decoration:none" class="" href="/parkinsons-website/">Quick and Efficient Extraction of Patient Specific SBR Ratios for Parkinson’s Disease</a></h1></div></div><div class="navbar-container"><nav><ul class="navbar-list"><li style="list-style-type:none;padding-left:1rem;padding-right:1rem"><a aria-current="page" style="text-decoration:none" class="" href="/parkinsons-website/">Home</a></li><li style="list-style-type:none;padding-left:1rem;padding-right:1rem"><a style="text-decoration:none" href="/parkinsons-website/background/">Background</a></li><li style="list-style-type:none;padding-left:1rem;padding-right:1rem"><a style="text-decoration:none" href="/parkinsons-website/donors/">Donors</a></li></ul></nav></div></div></header><div class="content-container"><div class="page-container"><h1 class="page-title">Home</h1><section class="section"><div class="text-block"><h2 class="section-title">Overview</h2><p>Parkinson&#x27;s disease is a complex neurological disorder, marked by a wide array of symptoms ranging from motor impairments to cognitive changes. Our research aims to enhance early biomarker discovery for Parkinson&#x27;s disease through analyzing and correlating imaging, clinical, and biological data.</p></div></section><section class="section"><h2 class="section-title">Early Biomarker Discovery Pipeline</h2><div class="image-container"><div data-gatsby-image-wrapper="" class="gatsby-image-wrapper gatsby-image-wrapper-constrained"><div style="max-width:3080px;display:block"><img alt="" role="presentation" aria-hidden="true" src="data:image/svg+xml;charset=utf-8,%3Csvg%20height=&#x27;1792&#x27;%20width=&#x27;3080&#x27;%20xmlns=&#x27;http://www.w3.org/2000/svg&#x27;%20version=&#x27;1.1&#x27;%3E%3C/svg%3E" style="max-width:100%;display:block;position:static"/></div><img aria-hidden="true" data-placeholder-image="" style="opacity:1;transition:opacity 500ms linear" decoding="async" src="data:image/png;base64,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" alt=""/><picture><source type="image/webp" data-srcset="/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/68949/discovery.webp 770w,/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/bef8e/discovery.webp 1540w,/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/cd4db/discovery.webp 3080w" sizes="(min-width: 3080px) 3080px, 100vw"/><img data-gatsby-image-ssr="" data-main-image="" style="opacity:0" sizes="(min-width: 3080px) 3080px, 100vw" decoding="async" loading="lazy" data-src="/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/dc1c9/discovery.png" data-srcset="/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/e81d0/discovery.png 770w,/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/f063b/discovery.png 1540w,/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/dc1c9/discovery.png 3080w" alt="Early Biomarker Discovery Pipeline"/></picture><noscript><picture><source type="image/webp" srcSet="/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/68949/discovery.webp 770w,/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/bef8e/discovery.webp 1540w,/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/cd4db/discovery.webp 3080w" sizes="(min-width: 3080px) 3080px, 100vw"/><img data-gatsby-image-ssr="" data-main-image="" style="opacity:0" sizes="(min-width: 3080px) 3080px, 100vw" decoding="async" loading="lazy" src="/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/dc1c9/discovery.png" srcSet="/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/e81d0/discovery.png 770w,/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/f063b/discovery.png 1540w,/parkinsons-website/static/27670bc422afe23939ee5a5ee496f0f1/dc1c9/discovery.png 3080w" alt="Early Biomarker Discovery Pipeline"/></picture></noscript><script type="module">const t="undefined"!=typeof HTMLImageElement&&"loading"in HTMLImageElement.prototype;if(t){const t=document.querySelectorAll("img[data-main-image]");for(let e of t){e.dataset.src&&(e.setAttribute("src",e.dataset.src),e.removeAttribute("data-src")),e.dataset.srcset&&(e.setAttribute("srcset",e.dataset.srcset),e.removeAttribute("data-srcset"));const t=e.parentNode.querySelectorAll("source[data-srcset]");for(let e of t)e.setAttribute("srcset",e.dataset.srcset),e.removeAttribute("data-srcset");e.complete&&(e.style.opacity=1,e.parentNode.parentNode.querySelector("[data-placeholder-image]").style.opacity=0)}}</script></div></div></section><section class="section"><div class="content-flex"><div class="text-block"><h2 class="section-title">Early Detection Primary Data</h2><p>The primary data we investigated for early detection was:</p><ol><li>Variables from curated data sheet (survey results)</li><li>REM Sleep data (sleep metrics)</li><li>Biologic data including CSF (Project 171)</li><li>Imaging data (T1 MRI, DaTSCAN, DTI)</li><li>UPDRS III for state representation (Part III: Motor examination: 18 items. Score range: 0–132, 32 and below is mild, 59 and above is severe.)</li></ol></div><div class="image-container"><div data-gatsby-image-wrapper="" class="gatsby-image-wrapper gatsby-image-wrapper-constrained"><div style="max-width:2438px;display:block"><img alt="" role="presentation" aria-hidden="true" src="data:image/svg+xml;charset=utf-8,%3Csvg%20height=&#x27;923.9999999999999&#x27;%20width=&#x27;2438&#x27;%20xmlns=&#x27;http://www.w3.org/2000/svg&#x27;%20version=&#x27;1.1&#x27;%3E%3C/svg%3E" style="max-width:100%;display:block;position:static"/></div><img aria-hidden="true" data-placeholder-image="" style="opacity:1;transition:opacity 500ms linear" decoding="async" src="data:image/png;base64,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" alt=""/><picture><source type="image/webp" data-srcset="/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/db70c/primary_data.webp 610w,/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/c89b3/primary_data.webp 1219w,/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/7d093/primary_data.webp 2438w" sizes="(min-width: 2438px) 2438px, 100vw"/><img data-gatsby-image-ssr="" data-main-image="" style="object-fit:contain;max-width:100%;max-height:45rem;opacity:0" sizes="(min-width: 2438px) 2438px, 100vw" decoding="async" loading="lazy" data-src="/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/e7af3/primary_data.png" data-srcset="/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/9cfe5/primary_data.png 610w,/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/9034e/primary_data.png 1219w,/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/e7af3/primary_data.png 2438w" alt="Table of primary data used in early detection"/></picture><noscript><picture><source type="image/webp" srcSet="/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/db70c/primary_data.webp 610w,/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/c89b3/primary_data.webp 1219w,/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/7d093/primary_data.webp 2438w" sizes="(min-width: 2438px) 2438px, 100vw"/><img data-gatsby-image-ssr="" data-main-image="" style="object-fit:contain;max-width:100%;max-height:45rem;opacity:0" sizes="(min-width: 2438px) 2438px, 100vw" decoding="async" loading="lazy" src="/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/e7af3/primary_data.png" srcSet="/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/9cfe5/primary_data.png 610w,/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/9034e/primary_data.png 1219w,/parkinsons-website/static/688b79cb81048d4763ac009a6a4cda87/e7af3/primary_data.png 2438w" alt="Table of primary data used in early detection"/></picture></noscript><script type="module">const t="undefined"!=typeof HTMLImageElement&&"loading"in HTMLImageElement.prototype;if(t){const t=document.querySelectorAll("img[data-main-image]");for(let e of t){e.dataset.src&&(e.setAttribute("src",e.dataset.src),e.removeAttribute("data-src")),e.dataset.srcset&&(e.setAttribute("srcset",e.dataset.srcset),e.removeAttribute("data-srcset"));const t=e.parentNode.querySelectorAll("source[data-srcset]");for(let e of t)e.setAttribute("srcset",e.dataset.srcset),e.removeAttribute("data-srcset");e.complete&&(e.style.opacity=1,e.parentNode.parentNode.querySelector("[data-placeholder-image]").style.opacity=0)}}</script></div></div></div></section><section class="section"><div class="content-flex"><div class="text-block"><h2 class="section-title">Biomarker Agent Training with DaTSCAN and T1 MRI</h2><p>For the identification of imaging patterns we started out investigating T1 - MRI data</p><ol><li>T1 - MRI highlights anatomy, providing crisp structural delineation. Volumes from T1- MRI for 112 prespecified regions were extracted for each patient</li><li>DaTSCAN images visualize striatal dopamine transporter intensity; commonly known to be a biomarker for PD. We utilize it to make improvement on SBR ratio extraction.</li></ol></div><div class="image-container"><div data-gatsby-image-wrapper="" class="gatsby-image-wrapper gatsby-image-wrapper-constrained"><div style="max-width:1360px;display:block"><img alt="" role="presentation" aria-hidden="true" src="data:image/svg+xml;charset=utf-8,%3Csvg%20height=&#x27;1646&#x27;%20width=&#x27;1360&#x27;%20xmlns=&#x27;http://www.w3.org/2000/svg&#x27;%20version=&#x27;1.1&#x27;%3E%3C/svg%3E" style="max-width:100%;display:block;position:static"/></div><img aria-hidden="true" data-placeholder-image="" style="opacity:1;transition:opacity 500ms linear" decoding="async" 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brain"/></picture></noscript><script type="module">const t="undefined"!=typeof HTMLImageElement&&"loading"in HTMLImageElement.prototype;if(t){const t=document.querySelectorAll("img[data-main-image]");for(let e of t){e.dataset.src&&(e.setAttribute("src",e.dataset.src),e.removeAttribute("data-src")),e.dataset.srcset&&(e.setAttribute("srcset",e.dataset.srcset),e.removeAttribute("data-srcset"));const t=e.parentNode.querySelectorAll("source[data-srcset]");for(let e of t)e.setAttribute("srcset",e.dataset.srcset),e.removeAttribute("data-srcset");e.complete&&(e.style.opacity=1,e.parentNode.parentNode.querySelector("[data-placeholder-image]").style.opacity=0)}}</script></div></div></div></section><section class="section"><div class="content-flex"><div class="text-block"><h2 class="section-title">Biomarker Agent Training with DTI, T2 MRI, and fMRI</h2><ol><li>DTI images detect the diffusion of water molecules in the white matter of the brain. We begin by extracting mean diffusivity and fractional anisotropy from 112 regions<ul><li>Substantia Nigra is the ROI based on literature</li><li>Will be investigated when T2 MRI is integrated</li></ul></li><li>This will eventually branch out into combining MRI with other imaging types such as T2-MRI and fMRI</li></ol></div><div class="image-container"><div data-gatsby-image-wrapper="" class="gatsby-image-wrapper gatsby-image-wrapper-constrained"><div style="max-width:1574px;display:block"><img alt="" role="presentation" aria-hidden="true" src="data:image/svg+xml;charset=utf-8,%3Csvg%20height=&#x27;1816&#x27;%20width=&#x27;1574&#x27;%20xmlns=&#x27;http://www.w3.org/2000/svg&#x27;%20version=&#x27;1.1&#x27;%3E%3C/svg%3E" style="max-width:100%;display:block;position:static"/></div><img aria-hidden="true" data-placeholder-image="" style="opacity:1;transition:opacity 500ms linear" decoding="async" 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) 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diff --git a/webpack.stats.json b/webpack.stats.json
index c0d494b..2ab5bf8 100644
--- a/webpack.stats.json
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