From 65180c183c0828dd093dd99a47b689ff3a76999f Mon Sep 17 00:00:00 2001 From: Jaclyn Taroni Date: Wed, 1 Apr 2020 14:19:38 -0400 Subject: [PATCH] #645 Part 5: Incorporate pathology feedback (#663) * Initialize molecular-subtyping-pathology w/ README * Add notebook that compiles molecular subtyping results * Add shell script for aggregation module * Add usage and module contents to README * Correct handling of CI params * Add subtyping aggregation step to CI * Add notebook for incorporating pathology feedback * Add second notebook to shell script * Add second notebook to README --- .../02-incorporate-pathology-feedback.Rmd | 263 ++ .../02-incorporate-pathology-feedback.nb.html | 3762 +++++++++++++++++ .../molecular-subtyping-pathology/README.md | 3 + ...cular_subtypes_with_pathology_feedback.tsv | 799 ++++ .../run-subtyping-aggregation.sh | 3 + 5 files changed, 4830 insertions(+) create mode 100644 analyses/molecular-subtyping-pathology/02-incorporate-pathology-feedback.Rmd create mode 100644 analyses/molecular-subtyping-pathology/02-incorporate-pathology-feedback.nb.html create mode 100644 analyses/molecular-subtyping-pathology/results/compiled_molecular_subtypes_with_pathology_feedback.tsv diff --git a/analyses/molecular-subtyping-pathology/02-incorporate-pathology-feedback.Rmd b/analyses/molecular-subtyping-pathology/02-incorporate-pathology-feedback.Rmd new file mode 100644 index 0000000000..5a002624fa --- /dev/null +++ b/analyses/molecular-subtyping-pathology/02-incorporate-pathology-feedback.Rmd @@ -0,0 +1,263 @@ +--- +title: "Incorporating CHOP pathology input to molecular subtyping calls" +output: + html_notebook: + toc: TRUE + toc_float: TRUE +author: Jaclyn Taroni for ALSF CCDL +date: 2020 +params: + is_ci: FALSE +--- + +_Authorship above refers to this notebook **only**._ + +## Background + +As part of this project, we have undertaken several analyses that use molecular data to subtype or reclassify biospecimens. +In some cases, our analyses have resulted in an update of the `integrated_diagnosis` field included in the clinical file (`pbta-histologies.tsv` [[doc](https://github.com/AlexsLemonade/OpenPBTA-analysis/blob/master/doc/data-formats.md#data-caveats)]). +However, not all logic included in the code of the repository was ultimately in agreement with feedback from pathologists at CHOP. +In this notebook, we will make changes and document the cases where the logic in the modules of the repository deviate from the final labels. + +## Pathology Feedback + +Here, we're copying the table from [#606 (comment)](https://github.com/AlexsLemonade/OpenPBTA-analysis/issues/609#issuecomment-602821376) here: + +| Kids_First_Biospecimen_ID | glioma_brain_region | sample_id | aliquot_id | Kids_First_Participant_ID | experimental_strategy | pathology_diagnosis | integrated_diagnosis | Notes from Path inspection | Action | Given to Rita 3/13/20 | short_histology | broad_histology | broad_composition | Notes | cancer_predispositions | molecular_subtype | +|---------------------------|---------------------|-----------|------------|---------------------------|-----------------------|--------------------------------------------------|------------------------------------------|---------------------------------------------------------------------------------------------|----------------------------------------------------------------------------------------|------------------------------------------------------------------------------------------------------------|-----------------|--------------------------------------------------------------------------|-------------------|-----------------------------------------------------------------------|------------------------|---------------------| +| BS_C6ZZ3FY5 | hemispheric | 7316-1105 | 470017 | PT_X71D7G5S | RNA-Seq | Supratentorial or Spinal Cord PNET | High-grade glioma | No path report available | reviewed - OK with new dx | 1 slide, pathology report | HGAT | Diffuse astrocytic and oligodendroglial tumor | tumor | Updated via OpenPBTA subtyping | None documented | HGG, H3 G35 | +| BS_P8WN8XEQ | hemispheric | 7316-1105 | 549712 | PT_X71D7G5S | WGS | Supratentorial or Spinal Cord PNET | High-grade glioma | No path report available | reviewed - OK with new dx | 1 slide, pathology report | HGAT | Diffuse astrocytic and oligodendroglial tumor | tumor | Updated via OpenPBTA subtyping | None documented | HGG, H3 G35 | +| BS_23M72ABG | NA | 7316-523 | 588343 | PT_AQWDQW27 | RNA-Seq | Meningioma | Ependymoma Meningioma | No path report available | reviewed - keep as meningioma | 2 slides, pathology report; email request for radiology | tumor | Ependymal tumor | tumor | | None documented | ST-EPN-YAP | +| BS_5JM573JC | hemispheric | 7316-2255 | 717166 | PT_6Q0NPVP3 | RNA-Seq | Ganglioglioma | Diffuse midline glioma | Path report ganglioglioma with extensive chondroid metaplasia | need to review radiology report; if not diffuse, ganglioglioma, H3 mut - cannot review | pathology report (no slides - from Pitt); email request for radiology - will not receive in the short term | HGAT | Diffuse astrocytic and oligodendroglial tumor | tumor | Updated via OpenPBTA subtyping | None documented | DMG, H3 K28 | +| BS_E5H6CFYT | hemispheric | 7316-2255 | 711134 | PT_6Q0NPVP3 | WGS | Ganglioglioma | Diffuse midline glioma | Path report ganglioglioma with extensive chondroid metaplasia | need to review radiology report; if not diffuse, ganglioglioma, H3 mut - cannot review | pathology report (no slides - from Pitt); email request for radiology - will not receive in the short term | HGAT | Diffuse astrocytic and oligodendroglial tumor | tumor | Updated via OpenPBTA subtyping | None documented | DMG, H3 K28 | +| BS_BFDEZK1C | other | 7316-1102 | 549714 | PT_5BWZA0NT | WGS | Supratentorial or Spinal Cord PNET | Diffuse midline glioma | No path report available | reviewed - OK with new dx | 3 slides, pathology report | HGAT | Diffuse astrocytic and oligodendroglial tumor | tumor | Updated via OpenPBTA subtyping | None documented | DMG, H3 K28 | +| BS_MB7WN0ZB | other | 7316-1102 | 470031 | PT_5BWZA0NT | RNA-Seq | Supratentorial or Spinal Cord PNET | Diffuse midline glioma | No path report available | reviewed - OK with new dx | 3 slides, pathology report | HGAT | Diffuse astrocytic and oligodendroglial tumor | tumor | Updated via OpenPBTA subtyping | None documented | DMG, H3 K28 | +| BS_H1XPVS9A | hemispheric | 7316-1106 | 549575 | PT_T8V9ES93 | RNA-Seq | High-grade glioma/astrocytoma (WHO grade III/IV) | High-grade glioma Low-grade glioma | No path report available | reviewed - OK with new dx (PXA/LGG) | 2 slides, pathology report | HGAT | Diffuse astrocytic and oligodendroglial tumor Low-grade astrocytic tumor | tumor | Updated via OpenPBTA subtyping | None documented | LGG, BRAF V600E | +| BS_J4E9SW51 | hemispheric | 7316-1106 | 549708 | PT_T8V9ES93 | WGS | High-grade glioma/astrocytoma (WHO grade III/IV) | High-grade glioma Low-grade glioma | No path report available | reviewed - OK with new dx (PXA/LGG) | 2 slides, pathology report | HGAT | Diffuse astrocytic and oligodendroglial tumor Low-grade astrocytic tumor | tumor | Updated via OpenPBTA subtyping | None documented | LGG, BRAF V600E | +| BS_J8VX4D17 | mixed | 7316-506 | 588299 | PT_7E3V3JFX | RNA-Seq | Ependymoma | Diffuse midline glioma Ependymoma | Path report posterior fossa ependymoma | reviewed - keep EPN with H3 mut- rare | | HGAT | Diffuse astrocytic and oligodendroglial tumor Ependymal tumor | tumor | Updated via OpenPBTA subtyping | None documented | DMG, H3 K28 | +| BS_G16NM5WJ | mixed | 7316-506 | 588011 | PT_7E3V3JFX | WGS | Ependymoma | Diffuse midline glioma Ependymoma | Path report posterior fossa ependymoma | reviewed - keep EPN with H3 mut- rare | | HGAT | Diffuse astrocytic and oligodendroglial tumor Ependymal tumor | tumor | Updated via OpenPBTA subtyping | None documented | DMG, H3 K28 | +| BS_KSKZ9J7J | NA | 7316-765 | 470731 | PT_80NVYCBS | RNA-Seq | Ependymoma | CNS Embryonal Tumor | Path report anaplastic ependymoma | reviewed - OK with new dx | | Embryonal Tumor | Embryonal tumor | tumor | Updated via OpenPBTA subtyping | None documented | CNS HGNET-MN1 | +| BS_K07KNTFY | NA | 7316-272 | 588001 | PT_00G007DM | WGS | Medulloblastoma | Embryonal tumor with multilayer rosettes | Path report had "medulloblastoma" handwritten, but final dx ETMR with multilayer rosettes | reviewed - OK with new dx | | ETMR | Embryonal tumor | tumor | Updated via OpenPBTA subtyping | None documented | ETMR, C19MC-altered | +| BS_QWNBZ9RJ | NA | 7316-272 | 588287 | PT_00G007DM | RNA-Seq | Medulloblastoma | Embryonal tumor with multilayer rosettes | Path report had "medulloblastoma" handwritten, but final dx ETMR with multilayer rosettes | reviewed - OK with new dx | | ETMR | Embryonal tumor | tumor | Updated via OpenPBTA subtyping | None documented | ETMR, C19MC-altered | +| BS_P39SQPTS | NA | 7316-447 | 588300 | PT_01MZ62KG | RNA-Seq | Pineoblastoma | Embryonal tumor with multilayer rosettes | Path report PNET/pineoblastoma; "there are scattered true rosettes (Flexner-Wintersteiner)" | reviewed - OK with new dx | | ETMR | Embryonal tumor | tumor | Updated via OpenPBTA subtyping | None documented | ETMR, C19MC-altered | +| BS_TE8QFF7T | NA | 7316-447 | 588012 | PT_01MZ62KG | WGS | Pineoblastoma | Embryonal tumor with multilayer rosettes | Path report PNET/pineoblastoma; "there are scattered true rosettes (Flexner-Wintersteiner)" | reviewed - OK with new dx | | ETMR | Embryonal tumor | tumor | Updated via OpenPBTA subtyping | None documented | ETMR, C19MC-altered | +| BS_N6N147BY | NA | 7316-238 | 232096 | PT_X648RVMK | RNA-Seq | High-grade glioma/astrocytoma (WHO grade III/IV) | Embryonal tumor with multilayer rosettes | Path report handwritten "high grade glioma"; final dx infiltrating glioneuronal neoplasm | reviewed - OK with new dx (ETMR original tumor 7316-2975 and this one consistent) | | ETMR | Embryonal tumor | tumor | Updated via OpenPBTA subtyping | None documented | ETMR, C19MC-altered | +| BS_5P1TN10Z | hemispheric | 7316-158 | 746061 | PT_9BZETM0M | RNA-Seq | Supratentorial or Spinal Cord PNET | High-grade glioma | Path report PNET | reviewed - OK with new dx grade III-IV | | HGAT | Diffuse astrocytic and oligodendroglial tumor | tumor | from PNET to HGG due to H3F3A mutation;Updated via OpenPBTA subtyping | None documented | HGG, H3 G35 | +| BS_STNH7YSX | hemispheric | 7316-158 | 746056 | PT_9BZETM0M | WGS | Supratentorial or Spinal Cord PNET | High-grade glioma | Path report PNET | reviewed - OK with new dx grade III-IV | | HGAT | Diffuse astrocytic and oligodendroglial tumor | tumor | from PNET to HGG due to H3F3A mutation;Updated via OpenPBTA subtyping | None documented | HGG, H3 G35 | +| BS_TV5B86ZD | hemispheric | 7316-158 | 150593 | PT_9BZETM0M | RNA-Seq | Supratentorial or Spinal Cord PNET | High-grade glioma | Path report PNET | reviewed - OK with new dx grade III-IV | | HGAT | Diffuse astrocytic and oligodendroglial tumor | tumor | from PNET to HGG due to H3F3A mutation;Updated via OpenPBTA subtyping | None documented | HGG, H3 G35 | + +And the notes: + +> #### Few notes: +> 1. `PT_7E3V3JFX` specimens were consistent with the original EPN dx, so pathology would call this a rare EPN, H3 K28 mutated tumor, rather than DMG. +> 2. `PT_AQWDQW27` specimen was consistent with meningioma, even though it has a hallmark EPN fusion, so pathology would also call this a rare meningioma with a _YAP1_ fusion. +> 3. Because 1 is a rare tumor (maybe first seen), the logic of searching for all H3 K28 mutations in [HGG subtyping](https://github.com/AlexsLemonade/OpenPBTA-analysis/issues/249) would convert this sample by default - how to handle this? +> 4. Pathology confirmed this HGG BRAF V600E mutant tumor, [`BS_H1XPVS9A`](https://cbethell.github.io/open-pbta-output/09-HGG-with-braf-clustering.nb.html#identify_sample_that_clusters_with_lgat), to be a LGAT (PXA). I updated `molecular_subtype` here based on what it would look like, but this should come through via the LGAT [subtyping](https://github.com/AlexsLemonade/OpenPBTA-analysis/issues/631) ticket. How should we add this info? + +## Set up + +```{r} +# This logic is the same as analyses/gene-set-enrichment-analysis/02-model-gsea.Rmd +# Assigning params$is_ci to running_in_ci avoids a locked binding error +running_in_ci <- params$is_ci + +# Are we testing? In case of a non 0/1 number, we recast as logical, and then +# ensure logical. +if (running_in_ci %in% c(0,1)) running_in_ci <- as.logical(running_in_ci) +if (!(is.logical(running_in_ci))) +{ + stop("\n\nERROR: The parameter `is_ci` should be FALSE/TRUE (or 0/1).") +} +``` + +```{r warning=FALSE} +library(tidyverse) +``` + +### Directory and files + +#### Directories + +```{r} +root_dir <- rprojroot::find_root(rprojroot::has_dir(".git")) +data_dir <- file.path(root_dir, "data") +results_dir <- "results" +``` + +#### Input + +When we run this locally, we want to tie it to a specific version of the histologies file _prior_ to feedback we received from pathology that is recorded on [#609](https://github.com/AlexsLemonade/OpenPBTA-analysis/issues/609). + +```{r} +if (running_in_ci) { + histologies_file <- file.path(data_dir, "pbta-histologies.tsv") +} else { + histologies_file <- file.path(data_dir, "release-v15-20200228", + "pbta-histologies.tsv") +} +``` + +```{r} +compiled_results_file <- file.path(results_dir, + "compiled_molecular_subtypes.tsv") +fusions_file <- file.path(data_dir, + "pbta-fusion-putative-oncogenic.tsv") +``` + +#### Output + +```{r} +output_file <- file.path(results_dir, + "compiled_molecular_subtypes_with_pathology_feedback.tsv") +``` + +## Read in data + +```{r message=FALSE} +histologies_df <- read_tsv(histologies_file, guess_max = 10000) +compiled_df <- read_tsv(compiled_results_file) +fusions_df <- read_tsv(fusions_file) +``` + +## Revise subtyping calls based on pathology feedback + +### `PT_7E3V3JFX` + +`PT_7E3V3JFX` was classified in `molecular-subtyping-HGG` as `DMG, H3 K28` because the first step in that module was to identify any samples in the cohort with "defining lesions:" H3 K28 or H3 G35 (original subtyping issue: [#249](https://github.com/AlexsLemonade/OpenPBTA-analysis/issues/249)). + +```{r} +compiled_df %>% + filter(Kids_First_Participant_ID == "PT_7E3V3JFX") +``` + +The relevant notes above are + +> 1. `PT_7E3V3JFX` specimens were consistent with the original EPN dx, so pathology would call this a rare EPN, H3 K28 mutated tumor, rather than DMG. +> 3. Because 1 is a rare tumor (maybe first seen), the logic of searching for all H3 K28 mutations in [HGG subtyping](https://github.com/AlexsLemonade/OpenPBTA-analysis/issues/249) would convert this sample by default - how to handle this? + +So we will revise the `molecular_subtype`, `integrated_diagnosis`, `short_histology`, and `broad_histology` accordingly. + +```{r} +compiled_df <- compiled_df %>% + mutate( + integrated_diagnosis = case_when( + Kids_First_Participant_ID == "PT_7E3V3JFX" ~ "Ependymoma", + TRUE ~ integrated_diagnosis + ), + short_histology = case_when( + Kids_First_Participant_ID == "PT_7E3V3JFX" ~ "Ependymoma", + TRUE ~ short_histology + ), + broad_histology = case_when( + Kids_First_Participant_ID == "PT_7E3V3JFX" ~ "Ependymal tumor", + TRUE ~ broad_histology + ), + molecular_subtype = case_when( + Kids_First_Participant_ID == "PT_7E3V3JFX" ~ "EPN, H3 K28", + TRUE ~ molecular_subtype + ) + ) +``` + +### `BS_H1XPVS9A` + +`BS_H1XPVS9A` is from a sample with a BRAF V600E mutation that is H3 wildtype. +This sample was originally labeled as a HGG. +In low-dimensional transcriptomic space (e.g., UMAP, t-SNE), `BS_H1XPVS9A` clusters with LGG samples. +(See `molecular-subtyping-HGG`.) + +The relevant note from above: + +> 4. Pathology confirmed this HGG BRAF V600E mutant tumor, `BS_H1XPVS9A` +to be a LGAT (PXA). I updated `molecular_subtype` here based on what it would look like, but this should come through via the LGAT [subtyping](https://github.com/AlexsLemonade/OpenPBTA-analysis/issues/631) ticket. How should we add this info? + +The steps for LGAT subtyping are to classify LGG samples on the basis of the presence/absence of _BRAF_ fusions and BRAF V600E mutations. + +```{r} +compiled_df %>% + filter(Kids_First_Biospecimen_ID == "BS_H1XPVS9A") %>% + select(Kids_First_Participant_ID, sample_id) %>% + left_join(compiled_df) +``` + +We know from `molecular-subtyping-HGG` that a BRAF V600E mutation is present. +Now we have to check for the presence of _BRAF_ fusions. + +```{r} +fusions_df %>% + filter(str_detect(FusionName, "BRAF"), + Sample == "BS_H1XPVS9A") +``` + +There are no _BRAF_ fusions in `BS_H1XPVS9A`, so we are able to classify this sample (`7316-1106`) as `LGG, BRAF V600E`. + +```{r} +compiled_df <- compiled_df %>% + mutate( + integrated_diagnosis = case_when( + sample_id == "7316-1106" ~ "Low-grade astrocytic tumor", + TRUE ~ integrated_diagnosis + ), + short_histology = case_when( + sample_id == "7316-1106" ~ "LGAT", + TRUE ~ short_histology + ), + broad_histology = case_when( + sample_id == "7316-1106" ~ "Low-grade astrocytic tumor", + TRUE ~ broad_histology + ), + molecular_subtype = case_when( + sample_id == "7316-1106" ~ "LGG, BRAF V600E", + TRUE ~ molecular_subtype + ), + Notes = case_when( + sample_id == "7316-1106" ~ "Updated via OpenPBTA subtyping", + TRUE ~ Notes + ) + ) +``` + +### HGG BRAF V600E + +The follow point comes from another issue [#627 (comment)](https://github.com/AlexsLemonade/OpenPBTA-analysis/issues/627#issuecomment-598789232): + +> We have a standalone BRAF V600E subtype, but this is HGG only, and should be labeled as such (will create an update HGG analysis ticket). + +```{r} +compiled_df %>% + filter(molecular_subtype == "BRAF V600E") +``` + +Now that we have addressed the one sample that should have been reclassified as LGG, we are able to update `molecular_subtype` to `HGG, BRAF V600E` for the remaining samples. + +```{r} +compiled_df <- compiled_df %>% + mutate(molecular_subtype = case_when( + molecular_subtype == "BRAF V600E" ~ "HGG, BRAF V600E", + TRUE ~ molecular_subtype + )) +``` + +### `PT_AQWDQW27` + +> 2. `PT_AQWDQW27` specimen was consistent with meningioma, even though it has a hallmark EPN fusion, so pathology would also call this a rare meningioma with a _YAP1_ fusion. + +The `molecular-subtyping-EPN` module has not been completed yet, but the logic that is in that module may mean that we need to include revising the labels of `PT_AQWDQW27`. + +``` +# TODO: do we need to update PT_AQWDQW27 once molecular-subtyping-EPN is +# complete? +``` + +### Write revised table to file + +```{r} +write_tsv(compiled_df, output_file) +``` + +## Session Info + +```{r} +sessionInfo() +``` + diff --git a/analyses/molecular-subtyping-pathology/02-incorporate-pathology-feedback.nb.html b/analyses/molecular-subtyping-pathology/02-incorporate-pathology-feedback.nb.html new file mode 100644 index 0000000000..3ea109e7b1 --- /dev/null +++ b/analyses/molecular-subtyping-pathology/02-incorporate-pathology-feedback.nb.html @@ -0,0 +1,3762 @@ + + + + + + + + + + + + + + + +Incorporating CHOP pathology input to molecular subtyping calls + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
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Authorship above refers to this notebook only.

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Background

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As part of this project, we have undertaken several analyses that use molecular data to subtype or reclassify biospecimens. In some cases, our analyses have resulted in an update of the integrated_diagnosis field included in the clinical file (pbta-histologies.tsv [doc]). However, not all logic included in the code of the repository was ultimately in agreement with feedback from pathologists at CHOP. In this notebook, we will make changes and document the cases where the logic in the modules of the repository deviate from the final labels.

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Pathology Feedback

+

Here, we’re copying the table from #606 (comment) here:

+ +++++++++++++++++++ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
Kids_First_Biospecimen_IDglioma_brain_regionsample_idaliquot_idKids_First_Participant_IDexperimental_strategypathology_diagnosisintegrated_diagnosisNotes from Path inspectionActionGiven to Rita 3/13/20short_histologybroad_histologybroad_compositionNotescancer_predispositionsmolecular_subtype
BS_C6ZZ3FY5hemispheric7316-1105470017PT_X71D7G5SRNA-SeqSupratentorial or Spinal Cord PNETHigh-grade gliomaNo path report availablereviewed - OK with new dx1 slide, pathology reportHGATDiffuse astrocytic and oligodendroglial tumortumorUpdated via OpenPBTA subtypingNone documentedHGG, H3 G35
BS_P8WN8XEQhemispheric7316-1105549712PT_X71D7G5SWGSSupratentorial or Spinal Cord PNETHigh-grade gliomaNo path report availablereviewed - OK with new dx1 slide, pathology reportHGATDiffuse astrocytic and oligodendroglial tumortumorUpdated via OpenPBTA subtypingNone documentedHGG, H3 G35
BS_23M72ABGNA7316-523588343PT_AQWDQW27RNA-SeqMeningiomaEpendymoma MeningiomaNo path report availablereviewed - keep as meningioma2 slides, pathology report; email request for radiologytumorEpendymal tumortumorNone documentedST-EPN-YAP
BS_5JM573JChemispheric7316-2255717166PT_6Q0NPVP3RNA-SeqGangliogliomaDiffuse midline gliomaPath report ganglioglioma with extensive chondroid metaplasianeed to review radiology report; if not diffuse, ganglioglioma, H3 mut - cannot reviewpathology report (no slides - from Pitt); email request for radiology - will not receive in the short termHGATDiffuse astrocytic and oligodendroglial tumortumorUpdated via OpenPBTA subtypingNone documentedDMG, H3 K28
BS_E5H6CFYThemispheric7316-2255711134PT_6Q0NPVP3WGSGangliogliomaDiffuse midline gliomaPath report ganglioglioma with extensive chondroid metaplasianeed to review radiology report; if not diffuse, ganglioglioma, H3 mut - cannot reviewpathology report (no slides - from Pitt); email request for radiology - will not receive in the short termHGATDiffuse astrocytic and oligodendroglial tumortumorUpdated via OpenPBTA subtypingNone documentedDMG, H3 K28
BS_BFDEZK1Cother7316-1102549714PT_5BWZA0NTWGSSupratentorial or Spinal Cord PNETDiffuse midline gliomaNo path report availablereviewed - OK with new dx3 slides, pathology reportHGATDiffuse astrocytic and oligodendroglial tumortumorUpdated via OpenPBTA subtypingNone documentedDMG, H3 K28
BS_MB7WN0ZBother7316-1102470031PT_5BWZA0NTRNA-SeqSupratentorial or Spinal Cord PNETDiffuse midline gliomaNo path report availablereviewed - OK with new dx3 slides, pathology reportHGATDiffuse astrocytic and oligodendroglial tumortumorUpdated via OpenPBTA subtypingNone documentedDMG, H3 K28
BS_H1XPVS9Ahemispheric7316-1106549575PT_T8V9ES93RNA-SeqHigh-grade glioma/astrocytoma (WHO grade III/IV)High-grade glioma Low-grade gliomaNo path report availablereviewed - OK with new dx (PXA/LGG)2 slides, pathology reportHGATDiffuse astrocytic and oligodendroglial tumor Low-grade astrocytic tumortumorUpdated via OpenPBTA subtypingNone documentedLGG, BRAF V600E
BS_J4E9SW51hemispheric7316-1106549708PT_T8V9ES93WGSHigh-grade glioma/astrocytoma (WHO grade III/IV)High-grade glioma Low-grade gliomaNo path report availablereviewed - OK with new dx (PXA/LGG)2 slides, pathology reportHGATDiffuse astrocytic and oligodendroglial tumor Low-grade astrocytic tumortumorUpdated via OpenPBTA subtypingNone documentedLGG, BRAF V600E
BS_J8VX4D17mixed7316-506588299PT_7E3V3JFXRNA-SeqEpendymomaDiffuse midline glioma EpendymomaPath report posterior fossa ependymomareviewed - keep EPN with H3 mut- rareHGATDiffuse astrocytic and oligodendroglial tumor Ependymal tumortumorUpdated via OpenPBTA subtypingNone documentedDMG, H3 K28
BS_G16NM5WJmixed7316-506588011PT_7E3V3JFXWGSEpendymomaDiffuse midline glioma EpendymomaPath report posterior fossa ependymomareviewed - keep EPN with H3 mut- rareHGATDiffuse astrocytic and oligodendroglial tumor Ependymal tumortumorUpdated via OpenPBTA subtypingNone documentedDMG, H3 K28
BS_KSKZ9J7JNA7316-765470731PT_80NVYCBSRNA-SeqEpendymomaCNS Embryonal TumorPath report anaplastic ependymomareviewed - OK with new dxEmbryonal TumorEmbryonal tumortumorUpdated via OpenPBTA subtypingNone documentedCNS HGNET-MN1
BS_K07KNTFYNA7316-272588001PT_00G007DMWGSMedulloblastomaEmbryonal tumor with multilayer rosettesPath report had “medulloblastoma” handwritten, but final dx ETMR with multilayer rosettesreviewed - OK with new dxETMREmbryonal tumortumorUpdated via OpenPBTA subtypingNone documentedETMR, C19MC-altered
BS_QWNBZ9RJNA7316-272588287PT_00G007DMRNA-SeqMedulloblastomaEmbryonal tumor with multilayer rosettesPath report had “medulloblastoma” handwritten, but final dx ETMR with multilayer rosettesreviewed - OK with new dxETMREmbryonal tumortumorUpdated via OpenPBTA subtypingNone documentedETMR, C19MC-altered
BS_P39SQPTSNA7316-447588300PT_01MZ62KGRNA-SeqPineoblastomaEmbryonal tumor with multilayer rosettesPath report PNET/pineoblastoma; “there are scattered true rosettes (Flexner-Wintersteiner)”reviewed - OK with new dxETMREmbryonal tumortumorUpdated via OpenPBTA subtypingNone documentedETMR, C19MC-altered
BS_TE8QFF7TNA7316-447588012PT_01MZ62KGWGSPineoblastomaEmbryonal tumor with multilayer rosettesPath report PNET/pineoblastoma; “there are scattered true rosettes (Flexner-Wintersteiner)”reviewed - OK with new dxETMREmbryonal tumortumorUpdated via OpenPBTA subtypingNone documentedETMR, C19MC-altered
BS_N6N147BYNA7316-238232096PT_X648RVMKRNA-SeqHigh-grade glioma/astrocytoma (WHO grade III/IV)Embryonal tumor with multilayer rosettesPath report handwritten “high grade glioma”; final dx infiltrating glioneuronal neoplasmreviewed - OK with new dx (ETMR original tumor 7316-2975 and this one consistent)ETMREmbryonal tumortumorUpdated via OpenPBTA subtypingNone documentedETMR, C19MC-altered
BS_5P1TN10Zhemispheric7316-158746061PT_9BZETM0MRNA-SeqSupratentorial or Spinal Cord PNETHigh-grade gliomaPath report PNETreviewed - OK with new dx grade III-IVHGATDiffuse astrocytic and oligodendroglial tumortumorfrom PNET to HGG due to H3F3A mutation;Updated via OpenPBTA subtypingNone documentedHGG, H3 G35
BS_STNH7YSXhemispheric7316-158746056PT_9BZETM0MWGSSupratentorial or Spinal Cord PNETHigh-grade gliomaPath report PNETreviewed - OK with new dx grade III-IVHGATDiffuse astrocytic and oligodendroglial tumortumorfrom PNET to HGG due to H3F3A mutation;Updated via OpenPBTA subtypingNone documentedHGG, H3 G35
BS_TV5B86ZDhemispheric7316-158150593PT_9BZETM0MRNA-SeqSupratentorial or Spinal Cord PNETHigh-grade gliomaPath report PNETreviewed - OK with new dx grade III-IVHGATDiffuse astrocytic and oligodendroglial tumortumorfrom PNET to HGG due to H3F3A mutation;Updated via OpenPBTA subtypingNone documentedHGG, H3 G35
+

And the notes:

+
+

Few notes:

+
    +
  1. PT_7E3V3JFX specimens were consistent with the original EPN dx, so pathology would call this a rare EPN, H3 K28 mutated tumor, rather than DMG.
    2. +
  2. PT_AQWDQW27 specimen was consistent with meningioma, even though it has a hallmark EPN fusion, so pathology would also call this a rare meningioma with a YAP1 fusion.
    3. +
  3. Because 1 is a rare tumor (maybe first seen), the logic of searching for all H3 K28 mutations in HGG subtyping would convert this sample by default - how to handle this?
    4. +
  4. Pathology confirmed this HGG BRAF V600E mutant tumor, BS_H1XPVS9A, to be a LGAT (PXA). I updated molecular_subtype here based on what it would look like, but this should come through via the LGAT subtyping ticket. How should we add this info?
    5. +
+
+
+
+

Set up

+ + + +
# This logic is the same as analyses/gene-set-enrichment-analysis/02-model-gsea.Rmd
+# Assigning params$is_ci to running_in_ci avoids a locked binding error
+running_in_ci <- params$is_ci
+
+# Are we testing? In case of a non 0/1 number, we recast as logical, and then 
+# ensure logical.
+if (running_in_ci %in% c(0,1)) running_in_ci <- as.logical(running_in_ci)
+if (!(is.logical(running_in_ci)))
+{
+  stop("\n\nERROR: The parameter `is_ci` should be FALSE/TRUE (or 0/1).")
+}
+ + + + + + +
library(tidyverse)
+ + +
Registered S3 method overwritten by 'dplyr':
+  method           from
+  print.rowwise_df     
+── Attaching packages ──────────────────────────────────────────────────────────────────────────────── tidyverse 1.2.1 ──
+✔ ggplot2 3.2.0     ✔ purrr   0.3.2
+✔ tibble  2.1.3     ✔ dplyr   0.8.3
+✔ tidyr   0.8.3     ✔ stringr 1.4.0
+✔ readr   1.3.1     ✔ forcats 0.4.0
+── Conflicts ─────────────────────────────────────────────────────────────────────────────────── tidyverse_conflicts() ──
+✖ dplyr::filter() masks stats::filter()
+✖ dplyr::lag()    masks stats::lag()
+ + + +
+

Directory and files

+
+

Directories

+ + + +
root_dir <- rprojroot::find_root(rprojroot::has_dir(".git"))
+data_dir <- file.path(root_dir, "data")
+results_dir <- "results"
+ + + +
+
+

Input

+

When we run this locally, we want to tie it to a specific version of the histologies file prior to feedback we received from pathology that is recorded on #609.

+ + + +
if (running_in_ci) {
+  histologies_file <- file.path(data_dir, "pbta-histologies.tsv")
+} else {
+  histologies_file <- file.path(data_dir, "release-v15-20200228",
+                                "pbta-histologies.tsv")
+}
+ + + + + + +
compiled_results_file <- file.path(results_dir, 
+                                   "compiled_molecular_subtypes.tsv")
+fusions_file <- file.path(data_dir,
+                          "pbta-fusion-putative-oncogenic.tsv")
+ + + +
+
+

Output

+ + + +
output_file <- file.path(results_dir,
+                         "compiled_molecular_subtypes_with_pathology_feedback.tsv")
+ + + +
+
+
+
+

Read in data

+ + + +
histologies_df <- read_tsv(histologies_file, guess_max = 10000)
+compiled_df <- read_tsv(compiled_results_file)
+fusions_df <- read_tsv(fusions_file)
+ + + +
+
+

Revise subtyping calls based on pathology feedback

+
+

PT_7E3V3JFX

+

PT_7E3V3JFX was classified in molecular-subtyping-HGG as DMG, H3 K28 because the first step in that module was to identify any samples in the cohort with “defining lesions:” H3 K28 or H3 G35 (original subtyping issue: #249).

+ + + +
compiled_df %>%
+  filter(Kids_First_Participant_ID == "PT_7E3V3JFX")
+ + +
+ +
+ + + +

The relevant notes above are

+
+
    +
  1. PT_7E3V3JFX specimens were consistent with the original EPN dx, so pathology would call this a rare EPN, H3 K28 mutated tumor, rather than DMG.
    2. +
  2. Because 1 is a rare tumor (maybe first seen), the logic of searching for all H3 K28 mutations in HGG subtyping would convert this sample by default - how to handle this?
    3. +
+
+

So we will revise the molecular_subtype, integrated_diagnosis, short_histology, and broad_histology accordingly.

+ + + +
compiled_df <- compiled_df %>%
+  mutate(
+    integrated_diagnosis = case_when(
+      Kids_First_Participant_ID == "PT_7E3V3JFX" ~ "Ependymoma",
+      TRUE ~ integrated_diagnosis 
+    ),
+    short_histology = case_when(
+      Kids_First_Participant_ID == "PT_7E3V3JFX" ~ "Ependymoma",
+      TRUE ~ short_histology
+    ),
+    broad_histology = case_when(
+      Kids_First_Participant_ID == "PT_7E3V3JFX" ~ "Ependymal tumor",
+      TRUE ~ broad_histology
+    ),
+    molecular_subtype = case_when(
+      Kids_First_Participant_ID == "PT_7E3V3JFX" ~ "EPN, H3 K28",
+      TRUE ~ molecular_subtype
+    )
+  )
+ + + +
+
+

BS_H1XPVS9A

+

BS_H1XPVS9A is from a sample with a BRAF V600E mutation that is H3 wildtype. This sample was originally labeled as a HGG. In low-dimensional transcriptomic space (e.g., UMAP, t-SNE), BS_H1XPVS9A clusters with LGG samples. (See molecular-subtyping-HGG.)

+

The relevant note from above:

+
+
    +
  1. Pathology confirmed this HGG BRAF V600E mutant tumor, BS_H1XPVS9A to be a LGAT (PXA). I updated molecular_subtype here based on what it would look like, but this should come through via the LGAT subtyping ticket. How should we add this info?
    2. +
+
+

The steps for LGAT subtyping are to classify LGG samples on the basis of the presence/absence of BRAF fusions and BRAF V600E mutations.

+ + + +
compiled_df %>%
+  filter(Kids_First_Biospecimen_ID == "BS_H1XPVS9A") %>%
+  select(Kids_First_Participant_ID, sample_id) %>%
+  left_join(compiled_df)
+ + +
Joining, by = c("Kids_First_Participant_ID", "sample_id")
+ + +
+ +
+ + + +

We know from molecular-subtyping-HGG that a BRAF V600E mutation is present. Now we have to check for the presence of BRAF fusions.

+ + + +
fusions_df %>%
+  filter(str_detect(FusionName, "BRAF"),
+         Sample == "BS_H1XPVS9A")
+ + +
+ +
+ + + +

There are no BRAF fusions in BS_H1XPVS9A, so we are able to classify this sample (7316-1106) as LGG, BRAF V600E.

+ + + +
compiled_df <- compiled_df %>%
+  mutate(
+    integrated_diagnosis = case_when(
+      sample_id == "7316-1106" ~ "Low-grade astrocytic tumor",
+      TRUE ~ integrated_diagnosis
+    ),
+    short_histology = case_when(
+      sample_id == "7316-1106" ~ "LGAT",
+      TRUE ~ short_histology
+    ),
+    broad_histology = case_when(
+      sample_id == "7316-1106" ~ "Low-grade astrocytic tumor",
+      TRUE ~ broad_histology
+    ),
+    molecular_subtype = case_when(
+      sample_id == "7316-1106" ~ "LGG, BRAF V600E",
+      TRUE ~ molecular_subtype
+    ),
+    Notes = case_when(
+      sample_id == "7316-1106" ~ "Updated via OpenPBTA subtyping",
+      TRUE ~ Notes
+    )
+  )
+ + + +
+
+

HGG BRAF V600E

+

The follow point comes from another issue #627 (comment):

+
+

We have a standalone BRAF V600E subtype, but this is HGG only, and should be labeled as such (will create an update HGG analysis ticket).

+
+ + + +
compiled_df %>%
+  filter(molecular_subtype == "BRAF V600E")
+ + +
+ +
+ + + +

Now that we have addressed the one sample that should have been reclassified as LGG, we are able to update molecular_subtype to HGG, BRAF V600E for the remaining samples.

+ + + +
compiled_df <- compiled_df %>%
+  mutate(molecular_subtype = case_when(
+    molecular_subtype == "BRAF V600E" ~ "HGG, BRAF V600E",
+    TRUE ~ molecular_subtype
+  ))
+ + + +
+
+

PT_AQWDQW27

+
+
    +
  1. PT_AQWDQW27 specimen was consistent with meningioma, even though it has a hallmark EPN fusion, so pathology would also call this a rare meningioma with a YAP1 fusion.
    2. +
+
+

The molecular-subtyping-EPN module has not been completed yet, but the logic that is in that module may mean that we need to include revising the labels of PT_AQWDQW27.

+
# TODO: do we need to update PT_AQWDQW27 once molecular-subtyping-EPN is 
+# complete?
+
+
+

Write revised table to file

+ + + +
write_tsv(compiled_df, output_file)
+ + + +
+
+
+

Session Info

+ + + +
sessionInfo()
+ + +
R version 3.6.0 (2019-04-26)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Debian GNU/Linux 9 (stretch)
+
+Matrix products: default
+BLAS/LAPACK: /usr/lib/libopenblasp-r0.2.19.so
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C               LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=C              LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C             LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] forcats_0.4.0   stringr_1.4.0   dplyr_0.8.3     purrr_0.3.2     readr_1.3.1     tidyr_0.8.3     tibble_2.1.3   
+[8] ggplot2_3.2.0   tidyverse_1.2.1
+
+loaded via a namespace (and not attached):
+ [1] Rcpp_1.0.1       cellranger_1.1.0 pillar_1.4.2     compiler_3.6.0   base64enc_0.1-3  tools_3.6.0     
+ [7] digest_0.6.20    lubridate_1.7.4  jsonlite_1.6     evaluate_0.14    nlme_3.1-140     gtable_0.3.0    
+[13] lattice_0.20-38  pkgconfig_2.0.2  rlang_0.4.0      cli_1.1.0        rstudioapi_0.10  yaml_2.2.0      
+[19] haven_2.1.1      xfun_0.8         withr_2.1.2      xml2_1.2.0       httr_1.4.0       knitr_1.23      
+[25] hms_0.4.2        generics_0.0.2   rprojroot_1.3-2  grid_3.6.0       tidyselect_0.2.5 glue_1.3.1      
+[31] R6_2.4.0         readxl_1.3.1     rmarkdown_1.13   modelr_0.1.4     magrittr_1.5     backports_1.1.4 
+[37] scales_1.0.0     htmltools_0.3.6  rvest_0.3.4      assertthat_0.2.1 colorspace_1.4-1 stringi_1.4.3   
+[43] lazyeval_0.2.2   munsell_0.5.0    broom_0.5.2      crayon_1.3.4
+ + + + +
+ +
---
title: "Incorporating CHOP pathology input to molecular subtyping calls"
output: 
  html_notebook:
    toc: TRUE
    toc_float: TRUE
author: Jaclyn Taroni for ALSF CCDL
date: 2020
params:
  is_ci: FALSE
---

_Authorship above refers to this notebook **only**._

## Background

As part of this project, we have undertaken several analyses that use molecular data to subtype or reclassify biospecimens. 
In some cases, our analyses have resulted in an update of the `integrated_diagnosis` field included in the clinical file (`pbta-histologies.tsv` [[doc](https://github.com/AlexsLemonade/OpenPBTA-analysis/blob/master/doc/data-formats.md#data-caveats)]).
However, not all logic included in the code of the repository was ultimately in agreement with feedback from pathologists at CHOP.
In this notebook, we will make changes and document the cases where the logic in the modules of the repository deviate from the final labels.

## Pathology Feedback

Here, we're copying the table from [#606 (comment)](https://github.com/AlexsLemonade/OpenPBTA-analysis/issues/609#issuecomment-602821376) here:

| Kids_First_Biospecimen_ID | glioma_brain_region | sample_id | aliquot_id | Kids_First_Participant_ID | experimental_strategy | pathology_diagnosis                              | integrated_diagnosis                     | Notes from Path inspection                                                                  | Action                                                                                 | Given to Rita 3/13/20                                                                                      | short_histology | broad_histology                                                          | broad_composition | Notes                                                                 | cancer_predispositions | molecular_subtype   |
|---------------------------|---------------------|-----------|------------|---------------------------|-----------------------|--------------------------------------------------|------------------------------------------|---------------------------------------------------------------------------------------------|----------------------------------------------------------------------------------------|------------------------------------------------------------------------------------------------------------|-----------------|--------------------------------------------------------------------------|-------------------|-----------------------------------------------------------------------|------------------------|---------------------|
| BS_C6ZZ3FY5               | hemispheric         | 7316-1105 | 470017     | PT_X71D7G5S               | RNA-Seq               | Supratentorial or Spinal Cord PNET               | High-grade glioma                        | No path report available                                                                    | reviewed - OK with new dx                                                              | 1 slide, pathology report                                                                                  | HGAT            | Diffuse astrocytic and oligodendroglial tumor                            | tumor             | Updated via OpenPBTA subtyping                                        | None documented        | HGG, H3 G35         |
| BS_P8WN8XEQ               | hemispheric         | 7316-1105 | 549712     | PT_X71D7G5S               | WGS                   | Supratentorial or Spinal Cord PNET               | High-grade glioma                        | No path report available                                                                    | reviewed - OK with new dx                                                              | 1 slide, pathology report                                                                                  | HGAT            | Diffuse astrocytic and oligodendroglial tumor                            | tumor             | Updated via OpenPBTA subtyping                                        | None documented        | HGG, H3 G35         |
| BS_23M72ABG               | NA                  | 7316-523  | 588343     | PT_AQWDQW27               | RNA-Seq               | Meningioma                                       | </s>Ependymoma</s> Meningioma                   | No path report available                                                                    | reviewed - keep as meningioma                                                          | 2 slides, pathology report; email request for radiology                                                    | tumor           | <s>Ependymal tumor</s>                                                          | tumor             |                                                                       | None documented        | <s>ST-EPN-YAP</s>          |
| BS_5JM573JC               | hemispheric         | 7316-2255 | 717166     | PT_6Q0NPVP3               | RNA-Seq               | Ganglioglioma                                    | Diffuse midline glioma                   | Path report ganglioglioma with extensive chondroid metaplasia                               | need to review radiology report; if not diffuse, ganglioglioma, H3 mut - cannot review | pathology report (no slides - from Pitt); email request for radiology - will not receive in the short term | HGAT            | Diffuse astrocytic and oligodendroglial tumor                            | tumor             | Updated via OpenPBTA subtyping                         | None documented        | DMG, H3 K28         |
| BS_E5H6CFYT               | hemispheric         | 7316-2255 | 711134     | PT_6Q0NPVP3               | WGS                   | Ganglioglioma                                    | Diffuse midline glioma                   | Path report ganglioglioma with extensive chondroid metaplasia                               | need to review radiology report; if not diffuse, ganglioglioma, H3 mut - cannot review | pathology report (no slides - from Pitt); email request for radiology - will not receive in the short term | HGAT            | Diffuse astrocytic and oligodendroglial tumor                            | tumor             | Updated via OpenPBTA subtyping                         | None documented        | DMG, H3 K28         |
| BS_BFDEZK1C               | other               | 7316-1102 | 549714     | PT_5BWZA0NT               | WGS                   | Supratentorial or Spinal Cord PNET               | Diffuse midline glioma                   | No path report available                                                                    | reviewed - OK with new dx                                                              | 3 slides, pathology report                                                                                 | HGAT            | Diffuse astrocytic and oligodendroglial tumor                            | tumor             | Updated via OpenPBTA subtyping                                        | None documented        | DMG, H3 K28         |
| BS_MB7WN0ZB               | other               | 7316-1102 | 470031     | PT_5BWZA0NT               | RNA-Seq               | Supratentorial or Spinal Cord PNET               | Diffuse midline glioma                   | No path report available                                                                    | reviewed - OK with new dx                                                              | 3 slides, pathology report                                                                                 | HGAT            | Diffuse astrocytic and oligodendroglial tumor                            | tumor             | Updated via OpenPBTA subtyping                                        | None documented        | DMG, H3 K28         |
| BS_H1XPVS9A               | hemispheric         | 7316-1106 | 549575     | PT_T8V9ES93               | RNA-Seq               | High-grade glioma/astrocytoma (WHO grade III/IV) | <s>High-grade glioma</s> Low-grade glioma       | No path report available                                                                    | reviewed - OK with new dx (PXA/LGG)                                                    | 2 slides, pathology report                                                                                 | HGAT            | <s>Diffuse astrocytic and oligodendroglial tumor</s> Low-grade astrocytic tumor | tumor             | Updated via OpenPBTA subtyping                                        | None documented        | LGG, BRAF V600E          |
| BS_J4E9SW51               | hemispheric         | 7316-1106 | 549708     | PT_T8V9ES93               | WGS                   | High-grade glioma/astrocytoma (WHO grade III/IV) | <s>High-grade glioma</s> Low-grade glioma       | No path report available                                                                    | reviewed - OK with new dx (PXA/LGG)                                                    | 2 slides, pathology report                                                                                 | HGAT            | <s>Diffuse astrocytic and oligodendroglial tumor</s> Low-grade astrocytic tumor | tumor             | Updated via OpenPBTA subtyping                                        | None documented        | LGG, BRAF V600E          |
| BS_J8VX4D17               | mixed               | 7316-506  | 588299     | PT_7E3V3JFX               | RNA-Seq               | Ependymoma                                       | <s>Diffuse midline glioma</s> Ependymoma        | Path report posterior fossa ependymoma                                                      | reviewed - keep EPN with H3 mut- rare                                                  |                                                                                                            | HGAT            | <s>Diffuse astrocytic and oligodendroglial tumor</s> Ependymal tumor            | tumor             | Updated via OpenPBTA subtyping                                        | None documented        | <s>DMG, H3 K28</s>         |
| BS_G16NM5WJ               | mixed               | 7316-506  | 588011     | PT_7E3V3JFX               | WGS                   | Ependymoma                                       | <s>Diffuse midline glioma</s> Ependymoma        | Path report posterior fossa ependymoma                                                      | reviewed - keep EPN with H3 mut- rare                                                  |                                                                                                            | HGAT            | <s>Diffuse astrocytic and oligodendroglial tumor</s> Ependymal tumor            | tumor             | Updated via OpenPBTA subtyping                                        | None documented        | <s>DMG, H3 K28</s>         |
| BS_KSKZ9J7J               | NA                  | 7316-765  | 470731     | PT_80NVYCBS               | RNA-Seq               | Ependymoma                                       | CNS Embryonal Tumor                      | Path report anaplastic ependymoma                                                           | reviewed - OK with new dx                                                              |                                                                                                            | Embryonal Tumor | Embryonal tumor                                                          | tumor             | Updated via OpenPBTA subtyping                                        | None documented        | CNS HGNET-MN1       |
| BS_K07KNTFY               | NA                  | 7316-272  | 588001     | PT_00G007DM               | WGS                   | Medulloblastoma                                  | Embryonal tumor with multilayer rosettes | Path report had "medulloblastoma" handwritten, but final dx ETMR with multilayer rosettes   | reviewed - OK with new dx                                                              |                                                                                                            | ETMR            | Embryonal tumor                                                          | tumor             | Updated via OpenPBTA subtyping                                        | None documented        | ETMR, C19MC-altered |
| BS_QWNBZ9RJ               | NA                  | 7316-272  | 588287     | PT_00G007DM               | RNA-Seq               | Medulloblastoma                                  | Embryonal tumor with multilayer rosettes | Path report had "medulloblastoma" handwritten, but final dx ETMR with multilayer rosettes   | reviewed - OK with new dx                                                              |                                                                                                            | ETMR            | Embryonal tumor                                                          | tumor             | Updated via OpenPBTA subtyping                                        | None documented        | ETMR, C19MC-altered |
| BS_P39SQPTS               | NA                  | 7316-447  | 588300     | PT_01MZ62KG               | RNA-Seq               | Pineoblastoma                                    | Embryonal tumor with multilayer rosettes | Path report PNET/pineoblastoma; "there are scattered true rosettes (Flexner-Wintersteiner)" | reviewed - OK with new dx                                                              |                                                                                                            | ETMR            | Embryonal tumor                                                          | tumor             | Updated via OpenPBTA subtyping                                        | None documented        | ETMR, C19MC-altered |
| BS_TE8QFF7T               | NA                  | 7316-447  | 588012     | PT_01MZ62KG               | WGS                   | Pineoblastoma                                    | Embryonal tumor with multilayer rosettes | Path report PNET/pineoblastoma; "there are scattered true rosettes (Flexner-Wintersteiner)" | reviewed - OK with new dx                                                              |                                                                                                            | ETMR            | Embryonal tumor                                                          | tumor             | Updated via OpenPBTA subtyping                                        | None documented        | ETMR, C19MC-altered |
| BS_N6N147BY               | NA                  | 7316-238  | 232096     | PT_X648RVMK               | RNA-Seq               | High-grade glioma/astrocytoma (WHO grade III/IV) | Embryonal tumor with multilayer rosettes | Path report handwritten "high grade glioma"; final dx infiltrating glioneuronal neoplasm    | reviewed - OK with new dx (ETMR original tumor 7316-2975 and this one consistent)      |                                                                                                            | ETMR            | Embryonal tumor                                                          | tumor             | Updated via OpenPBTA subtyping                                        | None documented        | ETMR, C19MC-altered |
| BS_5P1TN10Z               | hemispheric         | 7316-158  | 746061     | PT_9BZETM0M               | RNA-Seq               | Supratentorial or Spinal Cord PNET               | High-grade glioma                        | Path report PNET                                                                            | reviewed - OK with new dx grade III-IV                                                 |                                                                                                            | HGAT            | Diffuse astrocytic and oligodendroglial tumor                            | tumor             | from PNET to HGG due to H3F3A mutation;Updated via OpenPBTA subtyping | None documented        | HGG, H3 G35         |
| BS_STNH7YSX               | hemispheric         | 7316-158  | 746056     | PT_9BZETM0M               | WGS                   | Supratentorial or Spinal Cord PNET               | High-grade glioma                        | Path report PNET                                                                            | reviewed - OK with new dx grade III-IV                                                 |                                                                                                            | HGAT            | Diffuse astrocytic and oligodendroglial tumor                            | tumor             | from PNET to HGG due to H3F3A mutation;Updated via OpenPBTA subtyping | None documented        | HGG, H3 G35         |
| BS_TV5B86ZD               | hemispheric         | 7316-158  | 150593     | PT_9BZETM0M               | RNA-Seq               | Supratentorial or Spinal Cord PNET               | High-grade glioma                        | Path report PNET                                                                            | reviewed - OK with new dx grade III-IV                                                 |                                                                                                            | HGAT            | Diffuse astrocytic and oligodendroglial tumor                            | tumor             | from PNET to HGG due to H3F3A mutation;Updated via OpenPBTA subtyping | None documented        | HGG, H3 G35         |

And the notes:

> #### Few notes:
> 1. `PT_7E3V3JFX` specimens were consistent with the original EPN dx, so pathology would call this a rare EPN, H3 K28 mutated tumor, rather than DMG.
> 2. `PT_AQWDQW27` specimen was consistent with meningioma, even though it has a hallmark EPN fusion, so pathology would also call this a rare meningioma with a _YAP1_ fusion.
> 3. Because 1 is a rare tumor (maybe first seen), the logic of searching for all H3 K28 mutations in [HGG subtyping](https://github.com/AlexsLemonade/OpenPBTA-analysis/issues/249) would convert this sample by default - how to handle this? 
>  4. Pathology confirmed this HGG BRAF V600E mutant tumor, [`BS_H1XPVS9A`](https://cbethell.github.io/open-pbta-output/09-HGG-with-braf-clustering.nb.html#identify_sample_that_clusters_with_lgat), to be a LGAT (PXA). I updated `molecular_subtype` here based on what it would look like, but this should come through via the LGAT [subtyping](https://github.com/AlexsLemonade/OpenPBTA-analysis/issues/631) ticket. How should we add this info?

## Set up 

```{r}
# This logic is the same as analyses/gene-set-enrichment-analysis/02-model-gsea.Rmd
# Assigning params$is_ci to running_in_ci avoids a locked binding error
running_in_ci <- params$is_ci

# Are we testing? In case of a non 0/1 number, we recast as logical, and then 
# ensure logical.
if (running_in_ci %in% c(0,1)) running_in_ci <- as.logical(running_in_ci)
if (!(is.logical(running_in_ci)))
{
  stop("\n\nERROR: The parameter `is_ci` should be FALSE/TRUE (or 0/1).")
}
```

```{r warning=FALSE}
library(tidyverse)
```

### Directory and files

#### Directories

```{r}
root_dir <- rprojroot::find_root(rprojroot::has_dir(".git"))
data_dir <- file.path(root_dir, "data")
results_dir <- "results"
```

#### Input

When we run this locally, we want to tie it to a specific version of the histologies file _prior_ to feedback we received from pathology that is recorded on [#609](https://github.com/AlexsLemonade/OpenPBTA-analysis/issues/609).

```{r}
if (running_in_ci) {
  histologies_file <- file.path(data_dir, "pbta-histologies.tsv")
} else {
  histologies_file <- file.path(data_dir, "release-v15-20200228",
                                "pbta-histologies.tsv")
}
```

```{r}
compiled_results_file <- file.path(results_dir, 
                                   "compiled_molecular_subtypes.tsv")
fusions_file <- file.path(data_dir,
                          "pbta-fusion-putative-oncogenic.tsv")
```

#### Output

```{r}
output_file <- file.path(results_dir,
                         "compiled_molecular_subtypes_with_pathology_feedback.tsv")
```

## Read in data

```{r message=FALSE}
histologies_df <- read_tsv(histologies_file, guess_max = 10000)
compiled_df <- read_tsv(compiled_results_file)
fusions_df <- read_tsv(fusions_file)
```

## Revise subtyping calls based on pathology feedback

### `PT_7E3V3JFX`

`PT_7E3V3JFX` was classified in `molecular-subtyping-HGG` as `DMG, H3 K28` because the first step in that module was to identify any samples in the cohort with "defining lesions:" H3 K28 or H3 G35 (original subtyping issue: [#249](https://github.com/AlexsLemonade/OpenPBTA-analysis/issues/249)).

```{r}
compiled_df %>%
  filter(Kids_First_Participant_ID == "PT_7E3V3JFX")
```

The relevant notes above are

> 1. `PT_7E3V3JFX` specimens were consistent with the original EPN dx, so pathology would call this a rare EPN, H3 K28 mutated tumor, rather than DMG.
> 3. Because 1 is a rare tumor (maybe first seen), the logic of searching for all H3 K28 mutations in [HGG subtyping](https://github.com/AlexsLemonade/OpenPBTA-analysis/issues/249) would convert this sample by default - how to handle this? 

So we will revise the `molecular_subtype`, `integrated_diagnosis`, `short_histology`, and `broad_histology` accordingly.

```{r}
compiled_df <- compiled_df %>%
  mutate(
    integrated_diagnosis = case_when(
      Kids_First_Participant_ID == "PT_7E3V3JFX" ~ "Ependymoma",
      TRUE ~ integrated_diagnosis 
    ),
    short_histology = case_when(
      Kids_First_Participant_ID == "PT_7E3V3JFX" ~ "Ependymoma",
      TRUE ~ short_histology
    ),
    broad_histology = case_when(
      Kids_First_Participant_ID == "PT_7E3V3JFX" ~ "Ependymal tumor",
      TRUE ~ broad_histology
    ),
    molecular_subtype = case_when(
      Kids_First_Participant_ID == "PT_7E3V3JFX" ~ "EPN, H3 K28",
      TRUE ~ molecular_subtype
    )
  )
```

### `BS_H1XPVS9A`

`BS_H1XPVS9A` is from a sample with a BRAF V600E mutation that is H3 wildtype.
This sample was originally labeled as a HGG.
In low-dimensional transcriptomic space (e.g., UMAP, t-SNE), `BS_H1XPVS9A` clusters with LGG samples.
(See `molecular-subtyping-HGG`.)

The relevant note from above:

>  4. Pathology confirmed this HGG BRAF V600E mutant tumor, `BS_H1XPVS9A`
to be a LGAT (PXA). I updated `molecular_subtype` here based on what it would look like, but this should come through via the LGAT [subtyping](https://github.com/AlexsLemonade/OpenPBTA-analysis/issues/631) ticket. How should we add this info?

The steps for LGAT subtyping are to classify LGG samples on the basis of the presence/absence of _BRAF_ fusions and BRAF V600E mutations.

```{r}
compiled_df %>%
  filter(Kids_First_Biospecimen_ID == "BS_H1XPVS9A") %>%
  select(Kids_First_Participant_ID, sample_id) %>%
  left_join(compiled_df)
```

We know from `molecular-subtyping-HGG` that a BRAF V600E mutation is present.
Now we have to check for the presence of _BRAF_ fusions.

```{r}
fusions_df %>%
  filter(str_detect(FusionName, "BRAF"),
         Sample == "BS_H1XPVS9A")
```

There are no _BRAF_ fusions in `BS_H1XPVS9A`, so we are able to classify this sample (`7316-1106`) as `LGG, BRAF V600E`.

```{r}
compiled_df <- compiled_df %>%
  mutate(
    integrated_diagnosis = case_when(
      sample_id == "7316-1106" ~ "Low-grade astrocytic tumor",
      TRUE ~ integrated_diagnosis
    ),
    short_histology = case_when(
      sample_id == "7316-1106" ~ "LGAT",
      TRUE ~ short_histology
    ),
    broad_histology = case_when(
      sample_id == "7316-1106" ~ "Low-grade astrocytic tumor",
      TRUE ~ broad_histology
    ),
    molecular_subtype = case_when(
      sample_id == "7316-1106" ~ "LGG, BRAF V600E",
      TRUE ~ molecular_subtype
    ),
    Notes = case_when(
      sample_id == "7316-1106" ~ "Updated via OpenPBTA subtyping",
      TRUE ~ Notes
    )
  )
```

### HGG BRAF V600E

The follow point comes from another issue [#627 (comment)](https://github.com/AlexsLemonade/OpenPBTA-analysis/issues/627#issuecomment-598789232):

> We have a standalone BRAF V600E subtype, but this is HGG only, and should be labeled as such (will create an update HGG analysis ticket).

```{r}
compiled_df %>%
  filter(molecular_subtype == "BRAF V600E")
```

Now that we have addressed the one sample that should have been reclassified as LGG, we are able to update `molecular_subtype` to `HGG, BRAF V600E` for the remaining samples.

```{r}
compiled_df <- compiled_df %>%
  mutate(molecular_subtype = case_when(
    molecular_subtype == "BRAF V600E" ~ "HGG, BRAF V600E",
    TRUE ~ molecular_subtype
  ))
```

### `PT_AQWDQW27`

> 2. `PT_AQWDQW27` specimen was consistent with meningioma, even though it has a hallmark EPN fusion, so pathology would also call this a rare meningioma with a _YAP1_ fusion.

The `molecular-subtyping-EPN` module has not been completed yet, but the logic that is in that module may mean that we need to include revising the labels of `PT_AQWDQW27`.

```
# TODO: do we need to update PT_AQWDQW27 once molecular-subtyping-EPN is 
# complete?
```

### Write revised table to file

```{r}
write_tsv(compiled_df, output_file)
```

## Session Info

```{r}
sessionInfo()
```


+ + +
+
+ +
+ + + + + + + + diff --git a/analyses/molecular-subtyping-pathology/README.md b/analyses/molecular-subtyping-pathology/README.md index 8ff476ccfb..10dcd9d447 100644 --- a/analyses/molecular-subtyping-pathology/README.md +++ b/analyses/molecular-subtyping-pathology/README.md @@ -30,3 +30,6 @@ bash run-subtyping-aggregation.sh ### Module contents `01-compile-subtyping-results.Rmd` aggregates results from the modules listed above into a single table (`results/compiled_molecular_subtypes.tsv`). + +`02-incorporate-pathology-feedback.Rmd` incorporates pathology feedback for specific samples when the labels for those samples either need to be updated as a result of molecular subtyping or deviate from the logic in upstream molecular subtyping modules. +The output is an updated version of the table from `01-compile-subtyping-results.Rmd` (`results/compiled_molecular_subtypes_with_pathology_feedback.tsv`). \ No newline at end of file diff --git a/analyses/molecular-subtyping-pathology/results/compiled_molecular_subtypes_with_pathology_feedback.tsv b/analyses/molecular-subtyping-pathology/results/compiled_molecular_subtypes_with_pathology_feedback.tsv new file mode 100644 index 0000000000..4b8de087cc --- /dev/null +++ b/analyses/molecular-subtyping-pathology/results/compiled_molecular_subtypes_with_pathology_feedback.tsv @@ -0,0 +1,799 @@ +Kids_First_Participant_ID sample_id Kids_First_Biospecimen_ID molecular_subtype integrated_diagnosis short_histology broad_histology Notes +PT_00G007DM 7316-2577 BS_FEPRNEXX CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor changed from other to Ependymoblastoma per CBTTC all sheet;Updated via OpenPBTA subtyping +PT_00G007DM 7316-272 BS_QWNBZ9RJ ETMR, C19MC-altered Embryonal tumor with multilayer rosettes ETMR Embryonal tumor Updated via OpenPBTA subtyping +PT_01MZ62KG 7316-447 BS_P39SQPTS ETMR, C19MC-altered Embryonal tumor with multilayer rosettes ETMR Embryonal tumor Updated via OpenPBTA subtyping +PT_0PT33SCF 7316-1100 BS_09R7GDA7 CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_0T2EWNYR 7316-1981 BS_7BW0YRPY CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_218SX3G4 7316-529 BS_6T4JGBGY CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_38FS37DP 7316-2686 BS_DBEX7AG2 CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_7PXN3B4J 7316-784 BS_685DACMS ETMR, C19MC-altered Embryonal tumor with multilayer rosettes ETMR Embryonal tumor Updated via OpenPBTA subtyping +PT_80NVYCBS 7316-765 BS_KSKZ9J7J CNS HGNET-MN1 CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_8VRZRZ7R 7316-536 BS_QKT3TJVK CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_98QMQZY7 7316-464 BS_6NRTJSYK CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_9CSZBV2P 7316-1473 BS_YBJBSRHV CNS NB-FOXR2 CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_BDM0M83S 7316-3072 BS_CYEY58NY CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor changed from other to CNS embryonal tumor per CBTTC all sheet;Updated via OpenPBTA subtyping +PT_C73C5BBZ 7316-2658 BS_0HW7W7SD ETMR, NOS Embryonal tumor with multilayer rosettes ETMR Embryonal tumor changed from other to Medulloepithelioma per CBTTC all sheet;Updated via OpenPBTA subtyping +PT_CMB6TASJ 7316-505 BS_SXCZ3CXN CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_DQT78GS5 7316-3326 BS_37GTVG4N ETMR, C19MC-altered Embryonal tumor with multilayer rosettes ETMR Embryonal tumor changed from other to Embryonal tumor with multilayer rosettes NOS per CBTTC all sheet;Updated via OpenPBTA subtyping +PT_FF0MSK4D 7316-2987 BS_D0RDN4K5 CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_FMK5VFYW 7316-950 BS_FBJ5Q54N CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_FZHGKJ0H 7316-4033 BS_JBGZ7HHZ CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_FZHGKJ0H 7316-4034 BS_2SHWPB5P CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_NESAQHB1 7316-3689 BS_QT3NZ2YZ CNS NB-FOXR2 CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_NESAQHB1 7316-3844 BS_QHS3V0GP CNS NB-FOXR2 CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_RXT6KRR6 7316-3147 BS_NFRXNAFE CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_VBG3Z18B 7316-512 BS_ZQKGJD70 CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_VJBVXB08 7316-155 BS_ZQ76ZBEX CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_WE1CHTWK 7316-87 BS_1HQ76V6D CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_WE1CHTWK 7316-87 BS_JGA9BP3A CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_X648RVMK 7316-238 BS_N6N147BY ETMR, C19MC-altered Embryonal tumor with multilayer rosettes ETMR Embryonal tumor Updated via OpenPBTA subtyping +PT_00G007DM 7316-2577 BS_AQMKA8NC CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor changed from other to Ependymoblastoma per CBTTC all sheet;Updated via OpenPBTA subtyping +PT_00G007DM 7316-272 BS_K07KNTFY ETMR, C19MC-altered Embryonal tumor with multilayer rosettes ETMR Embryonal tumor Updated via OpenPBTA subtyping +PT_01MZ62KG 7316-447 BS_TE8QFF7T ETMR, C19MC-altered Embryonal tumor with multilayer rosettes ETMR Embryonal tumor Updated via OpenPBTA subtyping +PT_0PT33SCF 7316-1100 BS_KBPBCWA0 CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_0T2EWNYR 7316-1981 BS_AHT9PKVE CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_38FS37DP 7316-2686 BS_JX1PK0VW CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_98QMQZY7 7316-464 BS_JC8YV5V9 CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_BDM0M83S 7316-3072 BS_M16CDR44 CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor changed from other to CNS embryonal tumor per CBTTC all sheet;Updated via OpenPBTA subtyping +PT_CMB6TASJ 7316-505 BS_B73JK7T1 CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_DQT78GS5 7316-3326 BS_69VS8PS1 ETMR, C19MC-altered Embryonal tumor with multilayer rosettes ETMR Embryonal tumor changed from other to Embryonal tumor with multilayer rosettes NOS per CBTTC all sheet;Updated via OpenPBTA subtyping +PT_FF0MSK4D 7316-2987 BS_KJQXZ8GK CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_FMK5VFYW 7316-950 BS_80X7AVCP CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_FZHGKJ0H 7316-4033 BS_NHMPQ8Q1 CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_FZHGKJ0H 7316-4034 BS_5J5VH3X0 CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_NBY8PZR9 7316-871 BS_Z9NCH2XA CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_NESAQHB1 7316-3689 BS_6TMPZKSZ CNS NB-FOXR2 CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_NESAQHB1 7316-3844 BS_KJTW1RBN CNS NB-FOXR2 CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_RXT6KRR6 7316-3147 BS_CK7CPM73 CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_VJBVXB08 7316-155 BS_TF6H437Q CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_WE1CHTWK 7316-87 BS_4DY83R02 CNS Embryonal, NOS CNS Embryonal Tumor Embryonal Tumor Embryonal tumor Updated via OpenPBTA subtyping +PT_VHS5RM2K 7316-364 BS_0448A413 NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor Reclassified due to presence of hallmark EWS fusions +PT_HJMP6PH2 7316-3775 BS_1021ZGQT NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor NA +PT_X8S0H6TG 7316-876 BS_1N9XZXGE NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor Reclassified due to presence of hallmark EWS fusions +PT_FF0NV7ZM 7316-716 BS_4PWDGEB0 NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor Reclassified due to presence of hallmark EWS fusions +PT_SA94083W 7316-1856 BS_8S86CM61 NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor NA +PT_J50NZYZF 7316-956 BS_B9V8RGTA NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor Reclassified due to presence of hallmark EWS fusions +PT_F822DBA0 7316-458 BS_JFEZA9KE NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor Reclassified due to presence of hallmark EWS fusions +PT_EHE800JJ 7316-229 BS_JXF8A2A6 NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor Reclassified due to presence of hallmark EWS fusions +PT_J50NZYZF 7316-128 BS_PSNBFWQV NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor Reclassified due to presence of hallmark EWS fusions +PT_NBSRQAMS 7316-1079 BS_R4Y180DM NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor Reclassified due to presence of hallmark EWS fusions +PT_PJFTMJ6H 7316-2150 BS_WJGFDRWK NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor Reclassified due to presence of hallmark EWS fusions +PT_HJMP6PH2 7316-185 BS_XZTV0J8W NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor NA +PT_VHS5RM2K 7316-364 BS_FNM4BB83 NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor Reclassified due to presence of hallmark EWS fusions +PT_HJMP6PH2 7316-3775 BS_9SVMVJ45 NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor NA +PT_X8S0H6TG 7316-876 BS_ZECKZTFC NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor Reclassified due to presence of hallmark EWS fusions +PT_J50NZYZF 7316-956 BS_MWZCP1XW NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor Reclassified due to presence of hallmark EWS fusions +PT_F822DBA0 7316-458 BS_KPWRDRFP NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor Reclassified due to presence of hallmark EWS fusions +PT_J50NZYZF 7316-128 BS_J52D4XQY NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor Reclassified due to presence of hallmark EWS fusions +PT_NBSRQAMS 7316-1079 BS_Q9NHTR7G NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor Reclassified due to presence of hallmark EWS fusions +PT_PJFTMJ6H 7316-2150 BS_SSYNTXDC NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor Reclassified due to presence of hallmark EWS fusions +PT_HJMP6PH2 7316-185 BS_XKM2EAT4 NA Ewings Sarcoma EWS Mesenchymal non-meningothelial tumor NA +PT_0MXPTTM3 A09410 BS_R7NTZR4C HGG, IDH High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_1AAYYGGY A14709 BS_C83TK159 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_1DSX4VJM 7316-1708 BS_Q13FQ8FV DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_1E3E6GMF A09985 BS_JB43XBCQ DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_1YQH5NSH A20091 BS_R9B92M75 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_2JDDX6TJ 7316-409 BS_XZM79E42 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_3AWKWXEV 7316-85 BS_BYCX6VK1 HGG, BRAF V600E High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_40HTPY49 7316-466 BS_0VXZCRJS DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_4XB3YTJM 7316-388 BS_RX1YTZ7F DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_59D00MBQ 7316-1936 BS_ZVWE73JZ DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_59D00MBQ 7316-1937 BS_TM9MH0RP DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_5BWZA0NT 7316-1102 BS_MB7WN0ZB DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor from PNET to HGG due to H3F3A mutation;Updated via OpenPBTA subtyping +PT_63F63QY0 7316-3521 BS_VMQMGSJY DMG, H3 K28, BRAF V600E Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_6Q0NPVP3 7316-2255 BS_5JM573JC DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_7E3V3JFX 7316-506 BS_J8VX4D17 EPN, H3 K28 Ependymoma Ependymoma Ependymal tumor Updated via OpenPBTA subtyping +PT_7FZ8SE69 7316-2152 BS_4B0BAVTX DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_7P6J57H3 A12911 BS_XM1AHBDJ DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_858H7ABM 7316-903 BS_S5P8VTN5 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_9BZETM0M 7316-158 BS_5P1TN10Z HGG, H3 G35 High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor from PNET to HGG due to H3F3A mutation;Updated via OpenPBTA subtyping +PT_9BZETM0M 7316-158 BS_TV5B86ZD HGG, H3 G35 High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor from PNET to HGG due to H3F3A mutation;Updated via OpenPBTA subtyping +PT_9GKVQ9QS A05262 BS_GWSJ4Z9H DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_A06JR0E5 A17096 BS_X4DD4KSZ DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_B38P3Y5T 7316-3208 BS_97M1E2DW DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_C9YDTZPA A15726 BS_Z3RCA1T9 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_CSKHQB16 A14567 BS_QNNX91SM DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_DJ106XYS 7316-3935 BS_NR3P3GN2 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_DMAF1J4A A18552 BS_H97S5SQN DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_EN2RN5Y1 A17997 BS_NEVYM2FP DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_FYPWZBH0 7316-1085 BS_2A5R9MEJ DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_G16VK7FR A19649 BS_XGDPK33A DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_HGM20MW7 A09446 BS_5VPM0F36 DMG, H3 K28, BRAF V600E Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_HMF8J4EG 7316-644 BS_51RA1PGE DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_JNEV57VK 7316-2594 BS_VF5XWFXD DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_JNEV57VK 7316-3058 BS_D29RPBSZ DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_JSFBMK5V 7316-1769 BS_1A6MQ9ZA DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_JSFBMK5V 7316-392 BS_T3DGY9J9 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KAQMYFYB A16405 BS_EZ3147MX DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KTRJ8TFY A09689 BS_NGSG2KB6 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KZ56XHJT A08732 BS_FCDAH728 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KZ56XHJT A12398 BS_21ET39G7 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_M23Q0DC3 A03942 BS_JQVAWTTM DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_M9XXJ4GR A09576 BS_49CJNZ06 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_N3205P0D 7316-1099 BS_052PZFMK HGG, H3 G35 High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_NK8A49X5 A14449 BS_1N7MQZGR DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_NWYSD53S A15170 BS_ZF6BSFNF DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_P2NGYMG5 7316-1956 BS_GW0GKWMS DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_P5HHJJPH 7316-870 BS_4PPHAQXF HGG, BRAF V600E High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_PR4YBBH3 7316-116 BS_RXN5T5YT DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_PR4YBBH3 7316-126 BS_A7Q8G0Y1 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_QQZXYR4M 7316-1946 BS_8PNA0V6R HGG, IDH High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_QTDY0Y9A 7316-3771 BS_MDBT7S5Z DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_R4T1V1K4 7316-3206 BS_WH8G4VFB DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_RA6AGBA7 7316-461 BS_TRKH2SPE DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_RDJ40M73 7316-2561 BS_1EN5V3XW HGG, H3 G35 High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_RE6AXQM1 A19015 BS_6M2053M0 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_RYMG3M91 A18777 BS_68KX6A42 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_T8V9ES93 7316-1106 BS_H1XPVS9A LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor Updated via OpenPBTA subtyping +PT_V1HNAC2Q A07150 BS_8ZY4GST0 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_VCD0W8HG 7316-2756 BS_MWWZBQ60 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_VPEMAQBN A12748 BS_0ZA67BBC DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_W5GP3F6B A16915 BS_7WM3MNZ0 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_X5TQR8V2 7316-343 BS_BMMY0H73 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_X71D7G5S 7316-1105 BS_C6ZZ3FY5 HGG, H3 G35 High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor from PNET to HGG due to H3F3A mutation;Updated via OpenPBTA subtyping +PT_Y5KY6KN9 7316-195 BS_4QW2S1Q8 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_Y660CKCB 7316-3122 BS_XG0DBWVT DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_Y74CVASJ A16538 BS_2JP7RBMB DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_Y8RNS9JE 7316-1656 BS_X23724NJ HGG, BRAF V600E High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_Z4PJA6KT 7316-1763 BS_6WP1FHTE DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_0DXHDZJR 7316-2857 BS_QWS88QXE HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_0MXPTTM3 7316-3220 BS_8SYN7GXG HGG, IDH High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_0MXPTTM3 A09410 BS_H3TYF6GD HGG, IDH High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_0SPKM4S8 7316-2640 BS_VW4XN9Y7 HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_1AAYYGGY A14709 BS_1RTE2KEX DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_1DSX4VJM 7316-1708 BS_KYPMZZSY DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_1E3E6GMF 7316-3224 BS_7GKF6M85 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_1E3E6GMF A09985 BS_541KKASA DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_1H2REHT2 7316-3022 BS_79SYEHY3 HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_1H2REHT2 7316-3303 BS_96S0VQBN HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_1YQH5NSH A20091 BS_74TZJTW0 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_279D9QZ8 7316-325 BS_1YTHM07J HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_2JDDX6TJ 7316-409 BS_B9QP40ER DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_2WVW55DA 7316-2092 BS_M28HG0NT HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_2WVW55DA 7316-2100 BS_RG6JK7ZN HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_37B5JRP1 7316-2217 BS_EJV0N3BX HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_37B5JRP1 7316-2554 BS_8Q8N6AHW HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_387VK1T9 7316-3625 BS_F064HMTP HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_3AWKWXEV 7316-85 BS_E42SSQGJ HGG, BRAF V600E High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_3CHB9PK5 7316-2085 BS_8AY2GM4G HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_3CHB9PK5 7316-515 BS_20TBZG09 HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_3X3MF8ZD 7316-114 BS_3NX3RBCX HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_40HTPY49 7316-466 BS_T7WMJ08W DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_4347ZBEX 7316-913 BS_742CDKAS HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_4XB3YTJM 7316-388 BS_823V5X6Z DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_59D00MBQ 7316-1936 BS_QG6V29H7 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_59D00MBQ 7316-1937 BS_3E5C1PN1 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_59FJRPVX 7316-3769 BS_WJB33V17 HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_5BWZA0NT 7316-1102 BS_BFDEZK1C DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor from PNET to HGG due to H3F3A mutation;Updated via OpenPBTA subtyping +PT_63F63QY0 7316-3521 BS_KAD49R68 DMG, H3 K28, BRAF V600E Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_63HDZHCN 7316-2980 BS_S0T3CQ97 HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_6GDPNFA6 7316-2610 BS_XGVSX8BX HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_6Q0NPVP3 7316-2255 BS_E5H6CFYT DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_6SH7PV1N 7316-535 BS_MW63FCZC HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_7E3V3JFX 7316-506 BS_G16NM5WJ EPN, H3 K28 Ependymoma Ependymoma Ependymal tumor Updated via OpenPBTA subtyping +PT_7FZ8SE69 7316-2152 BS_KHSYAB3J DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_7P6J57H3 A12911 BS_Y0DGBKTY DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_7WT6P5M8 7316-2308 BS_JB3J82ZK HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_858H7ABM 7316-903 BS_872Q3FK2 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_89XRZBSG 7316-1789 BS_X1DSETVE HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_89XRZBSG 7316-445 BS_G9MQM1KK HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_8GN3TQRM 7316-2069 BS_QQP17PDQ HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_8GN3TQRM 7316-2091 BS_RXSBJ929 HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_8GN3TQRM 7316-2737 BS_S791VC80 HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_9BZETM0M 7316-158 BS_STNH7YSX HGG, H3 G35 High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor from PNET to HGG due to H3F3A mutation;Updated via OpenPBTA subtyping +PT_9GKVQ9QS 7316-3213 BS_3Z40EZHD DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_9GKVQ9QS 7316-3213 BS_JRFVST47 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_9GKVQ9QS A05262 BS_6B62YT97 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_A06JR0E5 A17096 BS_XPZAD9PP DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_A325EYR2 7316-2557 BS_YB99Q6TN HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_B38P3Y5T 7316-3208 BS_DH86PF5A DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_C5FKRB1P A14565 BS_A6YJ3WG2 HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_C9YDTZPA A15726 BS_74SJ7YV4 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_CSKHQB16 A14567 BS_CX6KACX6 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_DJ106XYS 7316-3935 BS_WJF6ZXWN DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_DMAF1J4A A18552 BS_JCWD4DMA DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_EN2RN5Y1 A17997 BS_328C4BW5 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_FYPWZBH0 7316-1085 BS_ZCY4ECNV DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_G16VK7FR A19649 BS_2HDEZFTW DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_HGM20MW7 7316-3221 BS_FK3B5SDH DMG, H3 K28, BRAF V600E Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_HGM20MW7 A09446 BS_52ETE050 DMG, H3 K28, BRAF V600E Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_HMF8J4EG 7316-644 BS_GKPVZXYP DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_HNZNZ635 7316-2151 BS_SKRY0BJ4 HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_J5NSRW1Y 7316-3817 BS_F8K4VQMF HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_JNEV57VK 7316-2594 BS_85Q5P8GF DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_JNEV57VK 7316-3058 BS_P0QJ1QAH DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_JSFBMK5V 7316-1769 BS_KY1CTGJ3 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_JSFBMK5V 7316-392 BS_H0638GZT DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KAQMYFYB A16405 BS_5CCAC8TZ DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KBFM551M 7316-3214 BS_M0B42FPR HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KBFM551M 7316-3214 BS_M5FM63EB HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KBFM551M 7316-3232 BS_9P4NDTKJ HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KBFM551M 7316-3237 BS_J8EK6RNF HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KBFM551M A07082 BS_WYTDVC0Y HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KEQ53KRH 7316-440 BS_R1G6SG0K HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KFYJBQB8 7316-3075 BS_NJFK43N3 HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KTRJ8TFY 7316-3223 BS_3VKW5988 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KTRJ8TFY 7316-3223 BS_BQ81D2BP DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KTRJ8TFY 7316-3230 BS_5968GBGT DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KTRJ8TFY 7316-3230 BS_AF5D41PD DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KTRJ8TFY 7316-3230 BS_EE73VE7V HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KTRJ8TFY 7316-3230 BS_HYKV2TH9 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KTRJ8TFY A09689 BS_402W79TS DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KVMF5TFW 7316-3030 BS_8FSJDG2T HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KZ04SDDS 7316-1774 BS_79NQJZ09 HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KZ56XHJT 7316-3217 BS_0ATJ22QA DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KZ56XHJT 7316-3217 BS_H8NWA41N DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KZ56XHJT 7316-3231 BS_1Q524P3B DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KZ56XHJT 7316-3231 BS_22VCR7DF DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KZ56XHJT 7316-3231 BS_AK9BV52G DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KZ56XHJT 7316-3231 BS_D6STCMQS DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KZ56XHJT 7316-3231 BS_X5VN0FW0 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KZ56XHJT 7316-3231 BS_YHXMYDBN DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KZ56XHJT A08732 BS_FWP8ZA4K DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_KZ56XHJT A12398 BS_9DN4QR6E DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_M23Q0DC3 7316-3212 BS_CGXTFM67 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_M23Q0DC3 A03942 BS_GBT44HST DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_M9XXJ4GR 7316-3222 BS_682Z7WH6 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_M9XXJ4GR 7316-3222 BS_R6CKWZW6 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_M9XXJ4GR A09576 BS_5FBN4PPQ DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_MDWPRDBT 7316-2146 BS_D368BNRD HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_MDWPRDBT 7316-2660 BS_00TRPEQX HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_MDWPRDBT 7316-2751 BS_1M63B97V HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_MDWPRDBT 7316-895 BS_BQWMQM2Y HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_MNSEJCDM 7316-3227 BS_CBMAWSAR DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_MNSEJCDM 7316-3227 BS_ZSH09N84 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_MNSEJCDM 7316-3229 BS_J8EH1N7V DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_MNSEJCDM 7316-3229 BS_Y74XAFJX DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_MSQ6GSVP 7316-2274 BS_HJ95JNFN HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_N3205P0D 7316-1099 BS_EPM623G4 HGG, H3 G35 High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_N32BYY8A 7316-89 BS_D6XHKZDZ HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_NK8A49X5 7316-3216 BS_1MME7FBS DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_NK8A49X5 7316-3228 BS_AHAXPFG3 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_NK8A49X5 7316-3228 BS_HEJ72V3F DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_NK8A49X5 A08692 BS_6DT506HY HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_NK8A49X5 A14449 BS_GKXD33YH DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_NWYSD53S A15170 BS_2KMB51YF DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_P2NGYMG5 7316-1956 BS_230S192D DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_P5HHJJPH 7316-870 BS_KXGJ1HMG HGG, BRAF V600E High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_PF9EC93Q 7316-3765 BS_80078QDG HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_PR4YBBH3 7316-116 BS_PPY0EWPG DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_PR4YBBH3 7316-126 BS_C2NH5FDT DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_PSX2CSYX 7316-46 BS_AFAHY6HP DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_QA9WJ679 7316-3218 BS_7PF3C1P7 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_QA9WJ679 A08768 BS_AEEKJ1QK HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_QDGVJKE0 7316-2140 BS_EP25TTAG HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_QQZXYR4M 7316-1946 BS_58X7SKJS HGG, IDH High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_QTDY0Y9A 7316-3771 BS_1S5V7WWC DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_R4T1V1K4 7316-3206 BS_23ZE42Q3 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_RA6AGBA7 7316-461 BS_P4K6WK9Y DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_RDJ40M73 7316-2561 BS_928HWFFM HGG, H3 G35 High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_RE6AXQM1 A19015 BS_6687ZNGS DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_RSDTCFDA 7316-204 BS_SK4H5MJQ HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_RYMG3M91 A18777 BS_QZPGVNBB DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_S0Q27J13 7316-2307 BS_P3PF53V8 HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_S2BEPYQ0 7316-3000 BS_ABZ3BK38 HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_SYHB12RN 7316-194 BS_9DM8H1RX HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_T8V9ES93 7316-1106 BS_J4E9SW51 LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor Updated via OpenPBTA subtyping +PT_V1HNAC2Q 7316-3215 BS_NNFDFAFM DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_V1HNAC2Q A07150 BS_7KR13R3P DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_VAJN5QP8 7316-2176 BS_KSHETTQC HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_VCD0W8HG 7316-2756 BS_TRGECFNP DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_VPEMAQBN 7316-3225 BS_Q6GVRAWK DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_VPEMAQBN A12748 BS_6VTQ3W4M DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_VTM2STE3 7316-2189 BS_02YBZSBY HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_VVCN8DXT 7316-71 BS_MSB1RDAJ HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_W5GP3F6B A16915 BS_P7VR731D DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_WGVEF96B 7316-3219 BS_TQ0J7WJQ DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_WGVEF96B A08958 BS_TYFD8ZMG HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_X5TQR8V2 7316-343 BS_C19DFVR5 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_X71D7G5S 7316-1105 BS_P8WN8XEQ HGG, H3 G35 High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor from PNET to HGG due to H3F3A mutation;Updated via OpenPBTA subtyping +PT_Y5KY6KN9 7316-195 BS_AYPBAHJ6 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_Y660CKCB 7316-3122 BS_FKQ7F6D1 DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_Y74CVASJ A16538 BS_KPG4WCHS DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_Y76A7PBA 7316-2288 BS_M4E4H6NG HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_Y8RNS9JE 7316-1656 BS_3BMGF6GN HGG, BRAF V600E High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_Z4BF2NSB 7316-161 BS_W2QCHQ7E HGG, H3 wildtype High-grade glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_Z4PJA6KT 7316-1763 BS_WPCBK1EG DMG, H3 K28 Diffuse midline glioma HGAT Diffuse astrocytic and oligodendroglial tumor Updated via OpenPBTA subtyping +PT_K39HM2JF 7316-1084 BS_HC5M8JTC LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_48N4Y6YP 7316-1866 BS_3G3KWY18 LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_41QYPSGV 7316-884 BS_9BJARSX3 LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_3MNY9BRY 7316-2583 BS_6VF6VPCG LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_4XVA57J7 7316-1760 BS_B3M5SGPA LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_RRT2E7HK 7316-136 BS_B0SVFK4P LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_TXFYRDP4 7316-193 BS_1G3WYEN3 LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_KMHGNCNR 7316-350 BS_T3H5AY8A LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_CM32ZCX6 7316-2215 BS_EYSS0ZDS LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_3T3VGWC6 7316-375 BS_7XRN3CFX LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_45YH276T 7316-499 BS_9P9MB8X8 LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_RKECV80K 7316-9 BS_ZVX2GRD6 LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_T1FV709B 7316-681 BS_EXGBH3TD LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_TD6ST5MG 7316-235 BS_2YCJV2VV LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_PFP1ZVHD 7316-2310 BS_DEHJF4C7 LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_N3HVMV06 7316-2075 BS_YCREDZTJ LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_BWGZBVD1 7316-1678 BS_4Z2F4P9N LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_KMHGNCNR 7316-944 BS_9DFBHHB5 LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_3T3VGWC6 7316-3923 BS_FJZPQZ2C LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_SRWZDG3N 7316-361 BS_24AHZ9ZW LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_FFRHWB74 7316-932 BS_2EMW8ZG3 LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_0CE0HFYB 7316-2581 BS_E3EJHXQV LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_DMMKT7X1 7316-1635 BS_C51RB0YR LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_1TGKS073 7316-1659 BS_X91K8KMG LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_YXJQGT69 7316-934 BS_GPEGRCCT LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_QK4XB83F 7316-663 BS_JG9JZTA9 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_3KK1F95W 7316-1744 BS_0X9EGHY2 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_Y572BRC1 7316-485 BS_V0Q1G94N LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_ATE3YRH5 7316-3308 BS_BPSTSCBJ LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_YGN06RPZ 7316-2208 BS_1KYGSMA7 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_Y8HSH496 7316-196 BS_X0F9AYEC LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_BQ8BQ01J 7316-183 BS_0T17SY47 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_8FWP7BR3 7316-449 BS_TMTV769C LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_EQ5C5TEA 7316-3922 BS_KEA474HN LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_VZTTTP3Q 7316-167 BS_E4QK839R LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_HV6C0T34 7316-3062 BS_XGSA3GQE LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2PRV78FX 7316-176 BS_E1CGF3KV LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_EF398HVC 7316-1975 BS_8J3B6ZB6 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_W3FSA7NH 7316-3522 BS_VARR255N LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_9C2G356W 7316-3555 BS_MBSTWZA6 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_Q3EP24V1 7316-154 BS_06AMMCXR LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_ZD9AYB6F 7316-3323 BS_QTSXW7DA LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_962TCBVR 7316-391 BS_VP3C8WZT LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_V07ZH5JS 7316-472 BS_V72GX2AZ LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_GCKT4FJX 7316-3919 BS_775HDFNY LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_HMY997GX 7316-3554 BS_3W07B2TG LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_F27SA15G 7316-1661 BS_YA8RBGD8 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_ZVV78QP5 7316-117 BS_DPF1CX0G LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_NNZQ09SH 7316-1109 BS_WVS02TZK LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_02J5CWN5 7316-2989 BS_M8WP5T16 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_K6G6BE6G 7316-1113 BS_A46RDWGM LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_EZEMVRVT 7316-3154 BS_F8N6CFQE LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_PFA762TK 7316-462 BS_K2VYFVKZ LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_E79807KT 7316-1087 BS_EYYMKWB7 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_CK41DW03 7316-329 BS_1JDG6JV5 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_YGN06RPZ 7316-2204 BS_X9EGD530 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_E78NHRWQ 7316-1081 BS_HSHN8PBB LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_S4YNE17X 7316-2899 BS_GR46VD0Q LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_JW6FBEFK 7316-3019 BS_3BVVWHP5 LGG, BRAF wildtype Subependymal Giant Cell Astrocytoma LGAT Low-grade astrocytic tumor NA +PT_YKVK5HTK 7316-441 BS_M4TTKPNR LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_6E8JYRXM 7316-2729 BS_JWSR581E LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_GQZ84ACS 7316-487 BS_53GQKVEX LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_JQ45JK94 7316-222 BS_QH82PBMB LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_HYXSSCJ5 7316-1088 BS_3P20Q2C3 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_SDK91A16 7316-247 BS_DSS3S5XD LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_3CVMBGD7 7316-1963 BS_9SJWWYQ4 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_FCM7XPVR 7316-2285 BS_MQCKXD60 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_TPSMT960 7316-400 BS_SHMC4902 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_50ZFWMZE 7316-1942 BS_X16PENSA LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2YT37G8P 7316-399 BS_PK18H7E7 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_7YGZ526E 7316-1978 BS_SXRS2P6T LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_5M8A47WW 7316-436 BS_ZZMYDZJW LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_JMW6Q6NH 7316-1648 BS_CB6VK7PB LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_J0SZ1SX5 7316-2589 BS_R13X6TMW LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_02J5CWN5 7316-898 BS_1RXZ3BP7 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_7YSCM82T 7316-1658 BS_AG3D3435 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_JPWVCTAJ 7316-1953 BS_R244Z0WX LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_6MWPJ96F 7316-1711 BS_NPQJ20KX LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_KXB1PJV0 7316-206 BS_3Q0GTSYH LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_VGXHFMND 7316-1643 BS_ET8CJXSF LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_H45M7M2T 7316-1652 BS_HX0S30NE LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_DEYCW197 7316-175 BS_HV8PFRBR LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_ZZTQQVCT 7316-2723 BS_Y7F9E2E9 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_GB8MNK85 7316-1086 BS_QC3XCE6X LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_5VAKED5F 7316-2689 BS_49852ZBH LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_1H2REHT2 7316-2990 BS_E0N3PTPN LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_7JQ24F35 7316-1681 BS_R634WKN7 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_NZFFMZ0B 7316-923 BS_K5802F84 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_XNMKQ4MR 7316-2006 BS_CTR5X93B LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_S2SQJVGK 7316-344 BS_JFR750KD LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2FVTD0WR 7316-2897 BS_YG0A13JH LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_JYZA0PNV 7316-437 BS_94MT16N2 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_EYZ25B99 7316-470 BS_ZRM0W01M LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_K30AWQ8A 7316-393 BS_M8M56Z4Y LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_Q25V9Y6M 7316-1668 BS_55P8HPYD LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_20ZM6THA 7316-3629 BS_E94QRJDW LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_N9CGVG02 7316-2197 BS_V89HGTET LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_4TASAQKA 7316-3566 BS_JVA2NQFF LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_XDV8W16W 7316-3751 BS_C6SKJG3N LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_D5KHK0SS 7316-882 BS_GWCRMKE6 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_5ABCFCSK 7316-1851 BS_A1VEGWTR LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_FAPEH6R1 7316-1660 BS_4NF35AF6 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_54MH6Q46 7316-2591 BS_PN2CE34A LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_06ERX8Z7 7316-2578 BS_29CPJ040 LGG, BRAF wildtype Subependymal Giant Cell Astrocytoma LGAT Low-grade astrocytic tumor NA +PT_NA8NZ0BN 7316-2135 BS_YEQVW4ND LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_KHX1WQ4H 7316-186 BS_BC936YNZ LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_E3ADF4ZB 7316-2664 BS_ZVZDDW2G LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_MBAXTJET 7316-275 BS_401R3KV0 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_H57TEQDT 7316-2324 BS_B7GEH89C LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2VSDT9CK 7316-3575 BS_G9XE3N9T LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_27FDWCVZ 7316-184 BS_G5QBBHDV LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_6N1QWCXE 7316-3169 BS_4HQ3T2NC LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_66XN3MT1 7316-936 BS_8Z3SCKB5 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_76Q72M5T 7316-397 BS_NYS8TRCB LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2ECVKTTQ 7316-173 BS_W3R88RFP LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_X1PRY0FC 7316-1779 BS_FJWZ3M7V LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_H45M7M2T 7316-3074 BS_YB2RXRHT LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_K63972GG 7316-666 BS_7P83Z28P LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2ECVKTTQ 7316-2154 BS_6P50QTPP LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_1KEER2Q1 7316-460 BS_YY5B2XDD LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2C63FJAM 7316-3040 BS_W4HGV6E7 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_DW6V5V8E 7316-924 BS_EFEZB0ZH LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_EEKE0V9T 7316-32 BS_5NWDARXG LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_QT3MK7BZ 7316-1977 BS_B6M763JS LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_VJ0M4E8Y 7316-2099 BS_CGB2WS2A LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_N9SG16EC 7316-1958 BS_4Y6BCYK5 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_XSS1ANXD 7316-495 BS_H8A9PSYA LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_TB8HPJBN 7316-2663 BS_A13BMEF5 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_0EWY6S6S 7316-3491 BS_470DYRJQ LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_DMHFS0HX 7316-3055 BS_YVMEEBKC LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_FKWCVXNC 7316-332 BS_17WYVEEC LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_41WETNRC 7316-3065 BS_BKQZ550R LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_M5HDHQNQ 7316-475 BS_9Q6Z6VJC LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_ZMKMKCFQ 7316-2988 BS_2R9TCR03 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_8R00BMHH 7316-1845 BS_EBMCTR80 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_EYHJQQ8E 7316-77 BS_G7AGNB5G LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_409Y4N1N 7316-84 BS_SFKZSJN1 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_Y572BRC1 7316-2193 BS_S4V9E1XJ LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2BJF83GQ 7316-1745 BS_02NZT8CE LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_0MHKP408 7316-726 BS_JH29M4KG LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_Y572BRC1 7316-2147 BS_EN2VK7NY LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_3SW2VHD5 7316-2984 BS_N5B2CZMH LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_6VJ5PNKS 7316-2174 BS_T2QPMZCM LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_SJEG0MKD 7316-146 BS_Z0AVVB1V LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_V2F0865M 7316-642 BS_0Y66ZBWE LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_TEBD1SES 7316-3054 BS_ZTWGFWTX LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_C1M4YF1R 7316-127 BS_NQB91P48 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_CB1XPA3W 7316-1767 BS_X59HSFGG LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_ADTP7EHN 7316-1664 BS_K7MVS0Z7 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_TH18S0JQ 7316-3068 BS_YZ2Z1Q6Y LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_1N6ATKJS 7316-2725 BS_SQX5E15Z LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_GVDMG7KC 7316-152 BS_WCRKYV0T LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_6DW5NFKX 7316-3150 BS_7H4RFCW9 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_S2CXXZCF 7316-643 BS_Y0PCBNJV LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_MPRBGGEJ 7316-2172 BS_S50KQEXV LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_7TEHW6VQ 7316-2755 BS_PEP9NZXN LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_6MWPJ96F 7316-1928 BS_VR7FR1NE LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_N8W26H19 7316-3061 BS_9DZ253JY LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_962TCBVR 7316-2744 BS_NRPG5K4K LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_ZR8MQRVG 7316-346 BS_NB5XWMJT LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_YZME6QCY 7316-2245 BS_68BW2163 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_JXGMAHHN 7316-874 BS_C7A2TYAC LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2YCHME6S 7316-2622 BS_EXYHZ6D4 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_1BV6ND1D 7316-3203 BS_H3FE3TH9 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_C2VY5NM6 7316-875 BS_9F09XV62 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_EW604JB3 7316-1134 BS_SDA4RMMG LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_4JG5KWE8 7316-50 BS_JKXA3FQC LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_WGWMA5AZ 7316-148 BS_13CGKADW LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2WVW55DA 7316-1890 BS_QAG1RDXN LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_12JTZFC2 7316-3504 BS_42DY6WS7 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_4Z34K4XB 7316-733 BS_Q79NP5YY LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_S21ZTKPS 7316-362 BS_014EVM2D LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_P9RT6693 7316-2566 BS_V3REENH9 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_YJBPEF4V 7316-938 BS_S1KK7XRH LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_ZRQQC2S9 7316-3139 BS_4EN8D8Y4 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_DQ3ZCHB6 7316-2195 BS_258RRGDM LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_RFF7MKTC 7316-954 BS_5YJEPPTP LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_YRMG61G8 7316-2305 BS_5PV5N4HQ LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_TS0FW57Z 7316-2167 BS_1ZVXF5FE LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_962TCBVR 7316-896 BS_WG203ECV LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_S0PBN4M7 7316-1805 BS_RWJZFTP9 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_SBHN5F68 7316-516 BS_6N3AFF66 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_NPPBNRVV 7316-1943 BS_D3YBV7KB LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_QAX38GM7 7316-3570 BS_044XZ8ST LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_H0HWHRPB 7316-1679 BS_N6NE6B3W LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_WVC247PK 7316-1090 BS_0J9SHHSC LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_5CNZ47XV 7316-1926 BS_JMHG7GCN LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_1VQWQ0TC 7316-3627 BS_47SJZ3PH LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2Z7GVDTM 7316-3515 BS_DV86M0Y7 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_3V5GTCJR 7316-1646 BS_063ERW0R LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_RXJZ3C5G 7316-2632 BS_8RCR7Y4B LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_VABP80N2 7316-1949 BS_21RE8W46 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2WVW55DA 7316-502 BS_D8N31T39 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_3J0ASVHN 7316-3622 BS_7Z93ZYMS LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2FVTD0WR 7316-917 BS_769BDPDB LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_5P3XJ97K 7316-390 BS_GYXSDZ56 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_RMK36R2E 7316-2275 BS_NS7GSHB9 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_WYF217NZ 7316-345 BS_52DAPP1Y LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_94EHCMXA 7316-217 BS_V7BJM89K LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_E1TRJP8V 7316-134 BS_HQ5BJ6MW LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_XXZHRPNM 7316-2572 BS_MF9X3PKH LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_QT9T89S5 7316-297 BS_T1W4JA94 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_1J2DT6MM 7316-2184 BS_GHNJ4CYC LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_N8W26H19 7316-267 BS_2KJ2YAZR LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_GHHY5AAE 7316-741 BS_EHVYJAVA LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_AC5SD9AC 7316-2291 BS_66HQ3E4Z LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_9B6KWJT2 7316-1226 BS_Z7Y2466H LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_3RN24N9X 7316-20 BS_NRFQEQKP LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_PGVQ4XRZ 7316-946 BS_AP0SZ364 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_4ZSR5DY8 7316-2667 BS_HA20Y4XY LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_S7WJ99PC 7316-677 BS_AVYNZHSB LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_8XZY6MM1 7316-957 BS_T4JFN54G LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_7JQ24F35 7316-1957 BS_1TPWFSK6 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_ZMKMKCFQ 7316-2753 BS_YMAJC22S LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_HXDCHQ9Y 7316-2171 BS_3EVSN5QD LGG, BRAF wildtype Subependymal Giant Cell Astrocytoma LGAT Low-grade astrocytic tumor NA +PT_FXPJM0MW 7316-207 BS_RRAEQZ97 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_6TKJRSPW 7316-162 BS_GCA4GET3 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_CB9PD1YP 7316-97 BS_CVGFNCBJ LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_5GQ76YZJ 7316-168 BS_SDZY6RZ3 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_S3FJSBJT 7316-1794 BS_ZV9Z3SY6 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_XWVQW6JX 7316-3556 BS_GYA4V1RD LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_PFA762TK 7316-368 BS_BN986DF6 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_CGPJY881 7316-891 BS_N1E0H8YQ LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_SMDEQVHJ 7316-119 BS_0SCXXM6N LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_YJGTKDV0 7316-1683 BS_Z6BWR941 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_BK92NM09 7316-2669 BS_Q3TBCK4V LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_NTK39NNV 7316-3076 BS_2ADZNNV4 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_YMN5GV47 7316-658 BS_VP5Y45Z7 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_BDNE55YT 7316-1710 BS_42Y3YANN LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_S2SQJVGK 7316-442 BS_S458NMKH LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_4ZSR5DY8 7316-264 BS_5CMGN56B LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_KQK98ZVP 7316-1803 BS_2WPQ8YCW LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_6R95FQT2 7316-459 BS_8VAZSJEN LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_VBNP6JFB 7316-1095 BS_T55Y4Z0Y LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_0K0DPVF6 7316-121 BS_66ABA973 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_XA8ASFJK 7316-3762 BS_KX6J8TRK LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_9M4CQX3M 7316-1972 BS_ARBQDTT5 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2YT37G8P 7316-2962 BS_VW85Q4XJ LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_A9F8Y6MA 7316-476 BS_4C4MZ4NT LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_MNR94DEV 7316-370 BS_0WVJYM9R LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_TH8M3W34 7316-2130 BS_25T139TX LGG, To be classified Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_BYJ428GA 7316-290 BS_3TQSE8HF LGG, To be classified Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_QJDY4Y9P 7316-562 BS_4A45GGSW LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_EXYXBDGP 7316-3140 BS_4BWB0FA0 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_3HRS5CWF 7316-925 BS_52426AMF LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_9D2N4S5Z 7316-93 BS_8SKZ7BRN LGG, To be classified Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_KBA2VNA2 7316-2249 BS_9755PSCS LGG, To be classified Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_P75ZXB1S 7316-692 BS_9HSGV9TJ LGG, To be classified Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_GQDHZFJP 7316-265 BS_CS170P7T LGG, To be classified Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_CG2S2H2R 7316-974 BS_J6VKB1VE LGG, To be classified Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_YPCR2XRS 7316-554 BS_MY9D8XZ1 LGG, To be classified Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_C95KPXSW 7316-869 BS_N210XMKR LGG, To be classified Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_B5VQ16GW 7316-488 BS_QRNSKFMS LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_BXXZE0CQ 7316-381 BS_S7CZY2CH LGG, To be classified Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_AYVKQZRB 7316-612 BS_T0RKFEKR LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_RV0RDER2 7316-262 BS_XKKB4MZV LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_K39HM2JF 7316-1084 BS_YEWX69X4 LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_48N4Y6YP 7316-1866 BS_8B1YF57H LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_41QYPSGV 7316-884 BS_CPYV7AHD LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_3MNY9BRY 7316-2583 BS_5R0HHQ1Y LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_4XVA57J7 7316-1760 BS_9NF39QAW LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_RRT2E7HK 7316-136 BS_JHGFJR3D LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_TXFYRDP4 7316-193 BS_5Z4XQC9X LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_KMHGNCNR 7316-350 BS_E7HEQZ1K LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_CM32ZCX6 7316-2215 BS_40SJZGT2 LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_3T3VGWC6 7316-375 BS_10AD3EFX LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_45YH276T 7316-499 BS_QC5FNXGH LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_RKECV80K 7316-9 BS_PEDGRK8S LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_T1FV709B 7316-681 BS_XH5JP8DB LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_TD6ST5MG 7316-235 BS_SE82EQF8 LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_PFP1ZVHD 7316-2310 BS_Z9PKZ4RT LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_N3HVMV06 7316-2075 BS_SD28E0SC LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_BWGZBVD1 7316-1678 BS_NZRJE7QA LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_KMHGNCNR 7316-944 BS_T5T21G7N LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_3T3VGWC6 7316-3923 BS_NCGGFG6H LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_SRWZDG3N 7316-361 BS_95RRF4NE LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_FFRHWB74 7316-932 BS_QDGHHS4S LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_0CE0HFYB 7316-2581 BS_30W38X77 LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_DMMKT7X1 7316-1635 BS_QMG7XNEW LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_1TGKS073 7316-1659 BS_CGCNC41M LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_YXJQGT69 7316-934 BS_NHRNZRQV LGG, BRAF V600E Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_QK4XB83F 7316-663 BS_01Y5F4PN LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_3KK1F95W 7316-1744 BS_03SSN1N2 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_Y572BRC1 7316-485 BS_042DVDQM LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_ATE3YRH5 7316-3308 BS_04B8X54S LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_YGN06RPZ 7316-2208 BS_060QB7XB LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_Y8HSH496 7316-196 BS_06GPPDHZ LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_BQ8BQ01J 7316-183 BS_0DKPGQWD LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_8FWP7BR3 7316-449 BS_0QEBZX3M LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_EQ5C5TEA 7316-3922 BS_0S617SMM LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_E66N7YBN 7316-35 BS_0XD58YD9 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_VZTTTP3Q 7316-167 BS_16FT8V4B LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_HV6C0T34 7316-3062 BS_16TBX6G5 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2PRV78FX 7316-176 BS_17AXPP1Y LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_EF398HVC 7316-1975 BS_1B4Q7CNG LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_W3FSA7NH 7316-3522 BS_1GK2EMFY LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_9C2G356W 7316-3555 BS_1VMBA3BN LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_Q3EP24V1 7316-154 BS_235QEYMQ LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_ZD9AYB6F 7316-3323 BS_245CTSH9 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_962TCBVR 7316-391 BS_2CQ6K2JW LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_V07ZH5JS 7316-472 BS_2F70R10Z LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_GCKT4FJX 7316-3919 BS_2HNHCSNB LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_HMY997GX 7316-3554 BS_2JDVY4F7 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_F27SA15G 7316-1661 BS_2NN6ME5A LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_ZVV78QP5 7316-117 BS_2RJN5Z4W LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_NNZQ09SH 7316-1109 BS_2SG8JNMB LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_02J5CWN5 7316-2989 BS_2VB8649B LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_K6G6BE6G 7316-1113 BS_3108RS7G LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_EZEMVRVT 7316-3154 BS_32HAVF6S LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_PFA762TK 7316-462 BS_32JF8TPP LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_T5CR5HQZ 7316-33 BS_36HCZ3KW LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_E79807KT 7316-1087 BS_3A0CJMRH LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_CK41DW03 7316-329 BS_3AERRZQT LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_YGN06RPZ 7316-2204 BS_3C4YAMKJ LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_E78NHRWQ 7316-1081 BS_3DYRAZE7 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_S4YNE17X 7316-2899 BS_3MYQP7P5 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_JW6FBEFK 7316-3019 BS_3P96RT4E LGG, BRAF wildtype Subependymal Giant Cell Astrocytoma LGAT Low-grade astrocytic tumor NA +PT_YKVK5HTK 7316-441 BS_3QDRWJCF LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_6E8JYRXM 7316-2729 BS_3R0KN6Z4 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_GQZ84ACS 7316-487 BS_3ZMH8578 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_GWX2XSM0 7316-2752 BS_41SWNWAG LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_JQ45JK94 7316-222 BS_41TD9XET LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_HYXSSCJ5 7316-1088 BS_45913DTA LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_SDK91A16 7316-247 BS_47454JJ6 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_3CVMBGD7 7316-1963 BS_49JD1V3S LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_FCM7XPVR 7316-2285 BS_4GKH983E LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_TPSMT960 7316-400 BS_4M0ZMCDC LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_50ZFWMZE 7316-1942 BS_4P25NNZD LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2YT37G8P 7316-399 BS_4QFSH7C4 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_7YGZ526E 7316-1978 BS_4ZKN0WGS LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_5M8A47WW 7316-436 BS_50XV7CTQ LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_JMW6Q6NH 7316-1648 BS_5BNV7MCF LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_J0SZ1SX5 7316-2589 BS_5NAKYS1S LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_02J5CWN5 7316-898 BS_5TT6TT4K LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_7YSCM82T 7316-1658 BS_5Y2Q63Y4 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_JPWVCTAJ 7316-1953 BS_6FV7BDE3 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_6MWPJ96F 7316-1711 BS_6GV08HTE LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_KXB1PJV0 7316-206 BS_6Q9PMNWY LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_VGXHFMND 7316-1643 BS_6X3Z0AVR LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_H45M7M2T 7316-1652 BS_6XHDR1WS LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_DEYCW197 7316-175 BS_6XP91JM2 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_ZZTQQVCT 7316-2723 BS_78TQS4Y3 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_GB8MNK85 7316-1086 BS_7HC4W4SA LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_5VAKED5F 7316-2689 BS_7M5272WN LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_1H2REHT2 7316-2990 BS_7M7JNG00 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_7JQ24F35 7316-1681 BS_895FJ34T LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_NZFFMZ0B 7316-923 BS_89RCN9PF LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_XNMKQ4MR 7316-2006 BS_8EB1S8MK LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_S2SQJVGK 7316-344 BS_8S2CZBA6 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2FVTD0WR 7316-2897 BS_8TFBNHT0 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_JYZA0PNV 7316-437 BS_8W0FNBWF LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_EYZ25B99 7316-470 BS_9E6Q11G2 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_K30AWQ8A 7316-393 BS_9GSWPZ44 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_Q25V9Y6M 7316-1668 BS_9HDPJT21 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_20ZM6THA 7316-3629 BS_9X9E86DY LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_N9CGVG02 7316-2197 BS_ABENB1H2 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_4TASAQKA 7316-3566 BS_AEMRNSQX LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_XDV8W16W 7316-3751 BS_AGGH3QGS LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_D5KHK0SS 7316-882 BS_AJ0T7DJ7 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_N8W26H19 7316-177 BS_AJAH8KG5 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_5ABCFCSK 7316-1851 BS_APAQ2X2S LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_FAPEH6R1 7316-1660 BS_ARE4EM81 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_54MH6Q46 7316-2591 BS_AXM96K20 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_06ERX8Z7 7316-2578 BS_B1X2SB4P LGG, BRAF wildtype Subependymal Giant Cell Astrocytoma LGAT Low-grade astrocytic tumor NA +PT_NA8NZ0BN 7316-2135 BS_B6K0N6HS LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_KHX1WQ4H 7316-186 BS_BNFCXVYZ LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_E3ADF4ZB 7316-2664 BS_C1RRDNF5 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_MBAXTJET 7316-275 BS_C6GBYR17 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_H57TEQDT 7316-2324 BS_CP435MAC LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2VSDT9CK 7316-3575 BS_CQ8C6X4X LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_27FDWCVZ 7316-184 BS_D09VWF8H LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_6N1QWCXE 7316-3169 BS_D2BZ25FW LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_66XN3MT1 7316-936 BS_DC7XYYG8 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_76Q72M5T 7316-397 BS_DT92H1MJ LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2ECVKTTQ 7316-173 BS_DW1CYEXP LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_X1PRY0FC 7316-1779 BS_E2RXQ3JW LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_R1DHB0ZT 7316-2642 BS_E9ATGWME LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_H45M7M2T 7316-3074 BS_E9M7TDB6 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_K63972GG 7316-666 BS_EQE19CB0 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2ECVKTTQ 7316-2154 BS_ERMGD2N5 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_1KEER2Q1 7316-460 BS_F1B71HTZ LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2C63FJAM 7316-3040 BS_F48RA7QF LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_DW6V5V8E 7316-924 BS_F4D169Q7 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_EEKE0V9T 7316-32 BS_F969DNHD LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_QT3MK7BZ 7316-1977 BS_F9ZTZ4YS LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_VJ0M4E8Y 7316-2099 BS_FFD25TTK LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_N9SG16EC 7316-1958 BS_FHFVCQ41 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_XSS1ANXD 7316-495 BS_FQ2ZBMPA LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_TB8HPJBN 7316-2663 BS_G2016BE5 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_0EWY6S6S 7316-3491 BS_GAA327FP LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_DMHFS0HX 7316-3055 BS_GCQEB05M LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_FKWCVXNC 7316-332 BS_GDPZN3SD LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_41WETNRC 7316-3065 BS_GFS9JEE6 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_M5HDHQNQ 7316-475 BS_GKN0B47F LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_ZMKMKCFQ 7316-2988 BS_GRS3T427 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_8R00BMHH 7316-1845 BS_H50HR85Y LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_EYHJQQ8E 7316-77 BS_HW4J7JM8 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_409Y4N1N 7316-84 BS_HW4MYBZ2 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_Y572BRC1 7316-2193 BS_J037K4BM LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2BJF83GQ 7316-1745 BS_J5J0EA7Y LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_0MHKP408 7316-726 BS_J6VRW67C LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_Y572BRC1 7316-2147 BS_JA3XXP1Y LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_3SW2VHD5 7316-2984 BS_JJNSP29S LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_6VJ5PNKS 7316-2174 BS_JJWC13GG LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_SJEG0MKD 7316-146 BS_JJZPY3BG LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_V2F0865M 7316-642 BS_JSMAT49K LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_TEBD1SES 7316-3054 BS_K3YT05M7 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_C1M4YF1R 7316-127 BS_K6BMXTW5 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_CB1XPA3W 7316-1767 BS_KCN7NG92 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_ADTP7EHN 7316-1664 BS_KG1YMTA4 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_TH18S0JQ 7316-3068 BS_KH0NFCWF LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_1N6ATKJS 7316-2725 BS_KKWQW01N LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_GVDMG7KC 7316-152 BS_KM878Y43 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_6DW5NFKX 7316-3150 BS_KT9H4B1N LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_S2CXXZCF 7316-643 BS_KVV3G6NP LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_MPRBGGEJ 7316-2172 BS_KYG3H6C6 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_7TEHW6VQ 7316-2755 BS_KYPZRS4S LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_6MWPJ96F 7316-1928 BS_M8EBKZDG LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_N8W26H19 7316-3061 BS_MBYEK6HV LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_962TCBVR 7316-2744 BS_ME97J1GA LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_MNHMAH0S 7316-880 BS_MJJZJMTK LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_ZR8MQRVG 7316-346 BS_MT5ZSRG4 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_YZME6QCY 7316-2245 BS_MW6YMRBJ LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_JXGMAHHN 7316-874 BS_MWKJF6XH LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2YCHME6S 7316-2622 BS_MZB884N9 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_1BV6ND1D 7316-3203 BS_MZJJRDZF LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_C2VY5NM6 7316-875 BS_N0Z6V2YG LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_EW604JB3 7316-1134 BS_N8D9FH6M LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_4JG5KWE8 7316-50 BS_N9N1X78X LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_WGWMA5AZ 7316-148 BS_NEX92KQH LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2WVW55DA 7316-1890 BS_NYVVN7SD LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_12JTZFC2 7316-3504 BS_P0KQFXNC LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_4Z34K4XB 7316-733 BS_P36C0ABE LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_S21ZTKPS 7316-362 BS_P3EVK3C2 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_P9RT6693 7316-2566 BS_P3KD5EQG LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_YJBPEF4V 7316-938 BS_PC2YQ4F6 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_ZRQQC2S9 7316-3139 BS_PEFRDKDZ LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_DQ3ZCHB6 7316-2195 BS_PMSZKZP7 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_RFF7MKTC 7316-954 BS_PP4WJBNR LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_YRMG61G8 7316-2305 BS_PV130A29 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_TS0FW57Z 7316-2167 BS_Q0XBZP88 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_962TCBVR 7316-896 BS_Q3ANJDVG LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_S0PBN4M7 7316-1805 BS_Q50P97Y0 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_SBHN5F68 7316-516 BS_Q5XKTB1V LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_NPPBNRVV 7316-1943 BS_QA0W86WP LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_QAX38GM7 7316-3570 BS_QD22MJJ5 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_H0HWHRPB 7316-1679 BS_QE5B0T7R LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_WVC247PK 7316-1090 BS_QK61ST4T LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_5CNZ47XV 7316-1926 BS_QM1Z8R38 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_1VQWQ0TC 7316-3627 BS_QXZTRMWM LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2Z7GVDTM 7316-3515 BS_QYWGB52C LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_3V5GTCJR 7316-1646 BS_QZTPJ8YW LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_RXJZ3C5G 7316-2632 BS_R726FKHP LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_VABP80N2 7316-1949 BS_R913E3VB LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2WVW55DA 7316-502 BS_R94EDP5H LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_3J0ASVHN 7316-3622 BS_R9V82BC1 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2FVTD0WR 7316-917 BS_RA0VCMWC LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_5P3XJ97K 7316-390 BS_RB8VSEVG LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_RMK36R2E 7316-2275 BS_RGSJMSRE LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_WYF217NZ 7316-345 BS_RZNNEX1Y LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_94EHCMXA 7316-217 BS_S88G7BXH LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_E1TRJP8V 7316-134 BS_SK949N33 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_XXZHRPNM 7316-2572 BS_SMCPASF0 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_QT9T89S5 7316-297 BS_T97EP8H0 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_1J2DT6MM 7316-2184 BS_THH0CE5A LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_N8W26H19 7316-267 BS_TZPJHKQR LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_GHHY5AAE 7316-741 BS_VA07453Z LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_AC5SD9AC 7316-2291 BS_VPJ9CARN LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_9B6KWJT2 7316-1226 BS_VQC2PE2B LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_3RN24N9X 7316-20 BS_VW96PFKQ LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_PGVQ4XRZ 7316-946 BS_VXNT1TDB LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_4ZSR5DY8 7316-2667 BS_W9FW1PAE LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_S7WJ99PC 7316-677 BS_W9P0PFDH LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_8XZY6MM1 7316-957 BS_WB8P21ED LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_7JQ24F35 7316-1957 BS_WD7AQV83 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_ZMKMKCFQ 7316-2753 BS_WDTT7PG2 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_HXDCHQ9Y 7316-2171 BS_WEGGXVYA LGG, BRAF wildtype Subependymal Giant Cell Astrocytoma LGAT Low-grade astrocytic tumor NA +PT_FXPJM0MW 7316-207 BS_WQ19Z6MD LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_6TKJRSPW 7316-162 BS_WRJNMEX2 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_CB9PD1YP 7316-97 BS_WSFB4SA2 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_5GQ76YZJ 7316-168 BS_WXKCR17Q LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_S3FJSBJT 7316-1794 BS_X9PJ715R LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_XWVQW6JX 7316-3556 BS_XBBBE8V2 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_PFA762TK 7316-368 BS_XHAQXDR0 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_CGPJY881 7316-891 BS_XKP747AS LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_SMDEQVHJ 7316-119 BS_XSWF2MR1 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_YJGTKDV0 7316-1683 BS_XVBX7ZK1 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_BK92NM09 7316-2669 BS_XVYRXN8J LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_NTK39NNV 7316-3076 BS_Y2C78JC4 LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_YMN5GV47 7316-658 BS_Y3ETG5AE LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_BDNE55YT 7316-1710 BS_Y43VC4VG LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_DA2TJAV1 7316-482 BS_Y4ZX0YX7 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_S2SQJVGK 7316-442 BS_YGQS4660 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_4ZSR5DY8 7316-264 BS_YH4DYNQ2 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_KQK98ZVP 7316-1803 BS_YMDPFK0V LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_6R95FQT2 7316-459 BS_YXCVR90M LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_VBNP6JFB 7316-1095 BS_YZ2YNEJJ LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_0K0DPVF6 7316-121 BS_Z4Q8RH5M LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_XA8ASFJK 7316-3762 BS_Z7R92XX6 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_9M4CQX3M 7316-1972 BS_ZAH4FHV2 LGG, BRAF wildtype Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_2YT37G8P 7316-2962 BS_ZJZFT0AJ LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_A9F8Y6MA 7316-476 BS_ZKZACPVV LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA +PT_MNR94DEV 7316-370 BS_ZP89F1JY LGG, BRAF fusion Low-grade astrocytic tumor LGAT Low-grade astrocytic tumor NA diff --git a/analyses/molecular-subtyping-pathology/run-subtyping-aggregation.sh b/analyses/molecular-subtyping-pathology/run-subtyping-aggregation.sh index 548316076b..25b6ae1626 100644 --- a/analyses/molecular-subtyping-pathology/run-subtyping-aggregation.sh +++ b/analyses/molecular-subtyping-pathology/run-subtyping-aggregation.sh @@ -18,3 +18,6 @@ cd "$(dirname "${BASH_SOURCE[0]}")" # Run the first notebook that compiles all the results from other modules into # a single table Rscript -e "rmarkdown::render('01-compile-subtyping-results.Rmd', params=list(is_ci = ${IS_CI}), clean = TRUE)" + +# Run the second notebook that incorporates pathology feedback into final labels +Rscript -e "rmarkdown::render('02-incorporate-pathology-feedback.Rmd', params=list(is_ci = ${IS_CI}), clean = TRUE)"