diff --git a/CHANGELOG.md b/CHANGELOG.md
index 4adc38e8989..dd068218d5c 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -23,6 +23,12 @@ See also the [v0.107.49 GitHub milestone][ms-v0.107.49].
 NOTE: Add new changes BELOW THIS COMMENT.
 -->
 
+### Added
+
+- Support for comments in the ipset file ([#5345]).
+
+[#5345]: https://github.com/AdguardTeam/AdGuardHome/issues/5345
+
 <!--
 NOTE: Add new changes ABOVE THIS COMMENT.
 -->
diff --git a/internal/dnsforward/config.go b/internal/dnsforward/config.go
index db2d50af20f..78f4acb6b3c 100644
--- a/internal/dnsforward/config.go
+++ b/internal/dnsforward/config.go
@@ -452,6 +452,7 @@ func (s *Server) prepareIpsetListSettings() (err error) {
 	}
 
 	ipsets := stringutil.SplitTrimmed(string(data), "\n")
+	ipsets = stringutil.FilterOut(ipsets, IsCommentOrEmpty)
 
 	log.Debug("dns: using %d ipset rules from file %q", len(ipsets), fn)